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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8ECY

cryoEM structure of bovine bestrophin-2 and glutamine synthetase complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0001525biological_processangiogenesis
A0003824molecular_functioncatalytic activity
A0004356molecular_functionglutamine synthetase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006542biological_processglutamine biosynthetic process
A0010594biological_processregulation of endothelial cell migration
A0016740molecular_functiontransferase activity
A0016874molecular_functionligase activity
A0018345biological_processprotein palmitoylation
A0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
A0045648biological_processpositive regulation of erythrocyte differentiation
A0046872molecular_functionmetal ion binding
A0097275biological_processintracellular ammonium homeostasis
A1903670biological_processregulation of sprouting angiogenesis
B0000166molecular_functionnucleotide binding
B0001525biological_processangiogenesis
B0003824molecular_functioncatalytic activity
B0004356molecular_functionglutamine synthetase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006542biological_processglutamine biosynthetic process
B0010594biological_processregulation of endothelial cell migration
B0016740molecular_functiontransferase activity
B0016874molecular_functionligase activity
B0018345biological_processprotein palmitoylation
B0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
B0045648biological_processpositive regulation of erythrocyte differentiation
B0046872molecular_functionmetal ion binding
B0097275biological_processintracellular ammonium homeostasis
B1903670biological_processregulation of sprouting angiogenesis
C0005254molecular_functionchloride channel activity
D0000166molecular_functionnucleotide binding
D0001525biological_processangiogenesis
D0003824molecular_functioncatalytic activity
D0004356molecular_functionglutamine synthetase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006542biological_processglutamine biosynthetic process
D0010594biological_processregulation of endothelial cell migration
D0016740molecular_functiontransferase activity
D0016874molecular_functionligase activity
D0018345biological_processprotein palmitoylation
D0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
D0045648biological_processpositive regulation of erythrocyte differentiation
D0046872molecular_functionmetal ion binding
D0097275biological_processintracellular ammonium homeostasis
D1903670biological_processregulation of sprouting angiogenesis
E0005254molecular_functionchloride channel activity
F0000166molecular_functionnucleotide binding
F0001525biological_processangiogenesis
F0003824molecular_functioncatalytic activity
F0004356molecular_functionglutamine synthetase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006542biological_processglutamine biosynthetic process
F0010594biological_processregulation of endothelial cell migration
F0016740molecular_functiontransferase activity
F0016874molecular_functionligase activity
F0018345biological_processprotein palmitoylation
F0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
F0045648biological_processpositive regulation of erythrocyte differentiation
F0046872molecular_functionmetal ion binding
F0097275biological_processintracellular ammonium homeostasis
F1903670biological_processregulation of sprouting angiogenesis
G0005254molecular_functionchloride channel activity
H0000166molecular_functionnucleotide binding
H0001525biological_processangiogenesis
H0003824molecular_functioncatalytic activity
H0004356molecular_functionglutamine synthetase activity
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0006542biological_processglutamine biosynthetic process
H0010594biological_processregulation of endothelial cell migration
H0016740molecular_functiontransferase activity
H0016874molecular_functionligase activity
H0018345biological_processprotein palmitoylation
H0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
H0045648biological_processpositive regulation of erythrocyte differentiation
H0046872molecular_functionmetal ion binding
H0097275biological_processintracellular ammonium homeostasis
H1903670biological_processregulation of sprouting angiogenesis
I0000166molecular_functionnucleotide binding
I0001525biological_processangiogenesis
I0003824molecular_functioncatalytic activity
I0004356molecular_functionglutamine synthetase activity
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0006542biological_processglutamine biosynthetic process
I0010594biological_processregulation of endothelial cell migration
I0016740molecular_functiontransferase activity
I0016874molecular_functionligase activity
I0018345biological_processprotein palmitoylation
I0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
I0045648biological_processpositive regulation of erythrocyte differentiation
I0046872molecular_functionmetal ion binding
I0097275biological_processintracellular ammonium homeostasis
I1903670biological_processregulation of sprouting angiogenesis
J0000166molecular_functionnucleotide binding
J0001525biological_processangiogenesis
J0003824molecular_functioncatalytic activity
J0004356molecular_functionglutamine synthetase activity
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0006542biological_processglutamine biosynthetic process
J0010594biological_processregulation of endothelial cell migration
J0016740molecular_functiontransferase activity
J0016874molecular_functionligase activity
J0018345biological_processprotein palmitoylation
J0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
J0045648biological_processpositive regulation of erythrocyte differentiation
J0046872molecular_functionmetal ion binding
J0097275biological_processintracellular ammonium homeostasis
J1903670biological_processregulation of sprouting angiogenesis
K0005254molecular_functionchloride channel activity
L0000166molecular_functionnucleotide binding
L0001525biological_processangiogenesis
L0003824molecular_functioncatalytic activity
L0004356molecular_functionglutamine synthetase activity
L0005515molecular_functionprotein binding
L0005524molecular_functionATP binding
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005829cellular_componentcytosol
L0005886cellular_componentplasma membrane
L0006542biological_processglutamine biosynthetic process
L0010594biological_processregulation of endothelial cell migration
L0016740molecular_functiontransferase activity
L0016874molecular_functionligase activity
L0018345biological_processprotein palmitoylation
L0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
L0045648biological_processpositive regulation of erythrocyte differentiation
L0046872molecular_functionmetal ion binding
L0097275biological_processintracellular ammonium homeostasis
L1903670biological_processregulation of sprouting angiogenesis
M0000166molecular_functionnucleotide binding
M0001525biological_processangiogenesis
M0003824molecular_functioncatalytic activity
M0004356molecular_functionglutamine synthetase activity
M0005515molecular_functionprotein binding
M0005524molecular_functionATP binding
M0005737cellular_componentcytoplasm
M0005739cellular_componentmitochondrion
M0005829cellular_componentcytosol
M0005886cellular_componentplasma membrane
M0006542biological_processglutamine biosynthetic process
M0010594biological_processregulation of endothelial cell migration
M0016740molecular_functiontransferase activity
M0016874molecular_functionligase activity
M0018345biological_processprotein palmitoylation
M0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
M0045648biological_processpositive regulation of erythrocyte differentiation
M0046872molecular_functionmetal ion binding
M0097275biological_processintracellular ammonium homeostasis
M1903670biological_processregulation of sprouting angiogenesis
N0005254molecular_functionchloride channel activity
Q0000166molecular_functionnucleotide binding
Q0001525biological_processangiogenesis
Q0003824molecular_functioncatalytic activity
Q0004356molecular_functionglutamine synthetase activity
Q0005515molecular_functionprotein binding
Q0005524molecular_functionATP binding
Q0005737cellular_componentcytoplasm
Q0005739cellular_componentmitochondrion
Q0005829cellular_componentcytosol
Q0005886cellular_componentplasma membrane
Q0006542biological_processglutamine biosynthetic process
Q0010594biological_processregulation of endothelial cell migration
Q0016740molecular_functiontransferase activity
Q0016874molecular_functionligase activity
Q0018345biological_processprotein palmitoylation
Q0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
Q0045648biological_processpositive regulation of erythrocyte differentiation
Q0046872molecular_functionmetal ion binding
Q0097275biological_processintracellular ammonium homeostasis
Q1903670biological_processregulation of sprouting angiogenesis
Functional Information from PROSITE/UniProt
site_idPS00180
Number of Residues18
DetailsGLNA_1 Glutamine synthetase signature 1. FDGSStfqsegs.NSDmyL
ChainResidueDetails
APHE62-LEU79
site_idPS00181
Number of Residues17
DetailsGLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIpgnw.NGAGcHtnfS
ChainResidueDetails
ALYS241-SER257
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues345
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"32251414","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35789156","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36289327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ECY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues130
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues775
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues5
DetailsBinding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"32251414","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35789156","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36289327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ECY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32251414","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35789156","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36289327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6VX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6VX9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8D1N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8ECY","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues800
DetailsDomain: {"description":"GS beta-grasp","evidences":[{"source":"PROSITE-ProRule","id":"PRU01330","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues230
DetailsRegion: {"description":"Required for glutamine-induced ubiquitination by CRL4(CRBN) and proteasomal degradation","evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues160
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues30
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P9WN39","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues10
DetailsModified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P15105","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues20
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues10
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P15105","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues10
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P15104","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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