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8ECY

cryoEM structure of bovine bestrophin-2 and glutamine synthetase complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0003824molecular_functioncatalytic activity
A0004356molecular_functionglutamine synthetase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006542biological_processglutamine biosynthetic process
A0010594biological_processregulation of endothelial cell migration
A0016740molecular_functiontransferase activity
A0016874molecular_functionligase activity
A0018345biological_processprotein palmitoylation
A0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
A0046872molecular_functionmetal ion binding
A1903670biological_processregulation of sprouting angiogenesis
B0001525biological_processangiogenesis
B0003824molecular_functioncatalytic activity
B0004356molecular_functionglutamine synthetase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006542biological_processglutamine biosynthetic process
B0010594biological_processregulation of endothelial cell migration
B0016740molecular_functiontransferase activity
B0016874molecular_functionligase activity
B0018345biological_processprotein palmitoylation
B0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
B0046872molecular_functionmetal ion binding
B1903670biological_processregulation of sprouting angiogenesis
C0005254molecular_functionchloride channel activity
D0001525biological_processangiogenesis
D0003824molecular_functioncatalytic activity
D0004356molecular_functionglutamine synthetase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005783cellular_componentendoplasmic reticulum
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006542biological_processglutamine biosynthetic process
D0010594biological_processregulation of endothelial cell migration
D0016740molecular_functiontransferase activity
D0016874molecular_functionligase activity
D0018345biological_processprotein palmitoylation
D0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
D0046872molecular_functionmetal ion binding
D1903670biological_processregulation of sprouting angiogenesis
E0005254molecular_functionchloride channel activity
F0001525biological_processangiogenesis
F0003824molecular_functioncatalytic activity
F0004356molecular_functionglutamine synthetase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005783cellular_componentendoplasmic reticulum
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006542biological_processglutamine biosynthetic process
F0010594biological_processregulation of endothelial cell migration
F0016740molecular_functiontransferase activity
F0016874molecular_functionligase activity
F0018345biological_processprotein palmitoylation
F0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
F0046872molecular_functionmetal ion binding
F1903670biological_processregulation of sprouting angiogenesis
G0005254molecular_functionchloride channel activity
H0001525biological_processangiogenesis
H0003824molecular_functioncatalytic activity
H0004356molecular_functionglutamine synthetase activity
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005783cellular_componentendoplasmic reticulum
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0006542biological_processglutamine biosynthetic process
H0010594biological_processregulation of endothelial cell migration
H0016740molecular_functiontransferase activity
H0016874molecular_functionligase activity
H0018345biological_processprotein palmitoylation
H0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
H0046872molecular_functionmetal ion binding
H1903670biological_processregulation of sprouting angiogenesis
I0001525biological_processangiogenesis
I0003824molecular_functioncatalytic activity
I0004356molecular_functionglutamine synthetase activity
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005783cellular_componentendoplasmic reticulum
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0006542biological_processglutamine biosynthetic process
I0010594biological_processregulation of endothelial cell migration
I0016740molecular_functiontransferase activity
I0016874molecular_functionligase activity
I0018345biological_processprotein palmitoylation
I0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
I0046872molecular_functionmetal ion binding
I1903670biological_processregulation of sprouting angiogenesis
J0001525biological_processangiogenesis
J0003824molecular_functioncatalytic activity
J0004356molecular_functionglutamine synthetase activity
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005783cellular_componentendoplasmic reticulum
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0006542biological_processglutamine biosynthetic process
J0010594biological_processregulation of endothelial cell migration
J0016740molecular_functiontransferase activity
J0016874molecular_functionligase activity
J0018345biological_processprotein palmitoylation
J0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
J0046872molecular_functionmetal ion binding
J1903670biological_processregulation of sprouting angiogenesis
K0005254molecular_functionchloride channel activity
L0001525biological_processangiogenesis
L0003824molecular_functioncatalytic activity
L0004356molecular_functionglutamine synthetase activity
L0005515molecular_functionprotein binding
L0005524molecular_functionATP binding
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005783cellular_componentendoplasmic reticulum
L0005829cellular_componentcytosol
L0005886cellular_componentplasma membrane
L0006542biological_processglutamine biosynthetic process
L0010594biological_processregulation of endothelial cell migration
L0016740molecular_functiontransferase activity
L0016874molecular_functionligase activity
L0018345biological_processprotein palmitoylation
L0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
L0046872molecular_functionmetal ion binding
L1903670biological_processregulation of sprouting angiogenesis
M0001525biological_processangiogenesis
M0003824molecular_functioncatalytic activity
M0004356molecular_functionglutamine synthetase activity
M0005515molecular_functionprotein binding
M0005524molecular_functionATP binding
M0005737cellular_componentcytoplasm
M0005739cellular_componentmitochondrion
M0005783cellular_componentendoplasmic reticulum
M0005829cellular_componentcytosol
M0005886cellular_componentplasma membrane
M0006542biological_processglutamine biosynthetic process
M0010594biological_processregulation of endothelial cell migration
M0016740molecular_functiontransferase activity
M0016874molecular_functionligase activity
M0018345biological_processprotein palmitoylation
M0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
M0046872molecular_functionmetal ion binding
M1903670biological_processregulation of sprouting angiogenesis
N0005254molecular_functionchloride channel activity
Q0001525biological_processangiogenesis
Q0003824molecular_functioncatalytic activity
Q0004356molecular_functionglutamine synthetase activity
Q0005515molecular_functionprotein binding
Q0005524molecular_functionATP binding
Q0005737cellular_componentcytoplasm
Q0005739cellular_componentmitochondrion
Q0005783cellular_componentendoplasmic reticulum
Q0005829cellular_componentcytosol
Q0005886cellular_componentplasma membrane
Q0006542biological_processglutamine biosynthetic process
Q0010594biological_processregulation of endothelial cell migration
Q0016740molecular_functiontransferase activity
Q0016874molecular_functionligase activity
Q0018345biological_processprotein palmitoylation
Q0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
Q0046872molecular_functionmetal ion binding
Q1903670biological_processregulation of sprouting angiogenesis
Functional Information from PROSITE/UniProt
site_idPS00180
Number of Residues18
DetailsGLNA_1 Glutamine synthetase signature 1. FDGSStfqsegs.NSDmyL
ChainResidueDetails
APHE62-LEU79

site_idPS00181
Number of Residues17
DetailsGLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIpgnw.NGAGcHtnfS
ChainResidueDetails
ALYS241-SER257

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues90
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P15104
ChainResidueDetails
AGLU134
JGLU134
JGLU136
JGLU196
JGLU203
JHIS253
JASN255
JARG324
JTYR336
JGLU338
LGLU134
AGLU136
LGLU136
LGLU196
LGLU203
LHIS253
LASN255
LARG324
LTYR336
LGLU338
QGLU134
QGLU136
AGLU196
QGLU196
QGLU203
QHIS253
QASN255
QARG324
QTYR336
QGLU338
HGLU134
HGLU136
HGLU196
AGLU203
HGLU203
HHIS253
HASN255
HARG324
HTYR336
HGLU338
DGLU134
DGLU136
DGLU196
DGLU203
AHIS253
DHIS253
DASN255
DARG324
DTYR336
DGLU338
BGLU134
BGLU136
BGLU196
BGLU203
BHIS253
AASN255
BASN255
BARG324
BTYR336
BGLU338
FGLU134
FGLU136
FGLU196
FGLU203
FHIS253
FASN255
AARG324
FARG324
FTYR336
FGLU338
IGLU134
IGLU136
IGLU196
IGLU203
IHIS253
IASN255
IARG324
ATYR336
ITYR336
IGLU338
MGLU134
MGLU136
MGLU196
MGLU203
MHIS253
MASN255
MARG324
MTYR336
AGLU338
MGLU338

site_idSWS_FT_FI2
Number of Residues30
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P9WN39
ChainResidueDetails
AASN246
QASN246
QARG319
QARG340
HASN246
HARG319
HARG340
DASN246
DARG319
DARG340
BASN246
AARG319
BARG319
BARG340
FASN246
FARG319
FARG340
IASN246
IARG319
IARG340
MASN246
MARG319
AARG340
MARG340
JASN246
JARG319
JARG340
LASN246
LARG319
LARG340

site_idSWS_FT_FI3
Number of Residues10
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P15105
ChainResidueDetails
AALA2
MALA2
JALA2
LALA2
QALA2
HALA2
DALA2
BALA2
FALA2
IALA2

site_idSWS_FT_FI4
Number of Residues10
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P15105
ChainResidueDetails
ATYR104
MTYR104
JTYR104
LTYR104
QTYR104
HTYR104
DTYR104
BTYR104
FTYR104
ITYR104

site_idSWS_FT_FI5
Number of Residues10
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P15104
ChainResidueDetails
ASER343
MSER343
GASP301
GASP304
KGLN293
KASN296
KASP301
KASP304
NGLN293
NASN296
NASP301
JSER343
NASP304
LSER343
QSER343
HSER343
DSER343
BSER343
FSER343
ISER343

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PDB entries from 2024-07-24

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