8EC0

III2IV respiratory supercomplex from Saccharomyces cerevisiae cardiolipin-lacking mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004222	molecular_function	metalloendopeptidase activity
a	0005515	molecular_function	protein binding
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0005750	cellular_component	mitochondrial respiratory chain complex III
a	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
a	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
a	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
a	0009060	biological_process	aerobic respiration
a	0045333	biological_process	cellular respiration
a	0046872	molecular_function	metal ion binding
a	0070469	cellular_component	respirasome
a	1902600	biological_process	proton transmembrane transport
A	0004222	molecular_function	metalloendopeptidase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005750	cellular_component	mitochondrial respiratory chain complex III
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
A	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
A	0009060	biological_process	aerobic respiration
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	0070469	cellular_component	respirasome
A	1902600	biological_process	proton transmembrane transport
b	0004222	molecular_function	metalloendopeptidase activity
b	0005515	molecular_function	protein binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0005750	cellular_component	mitochondrial respiratory chain complex III
b	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
b	0006508	biological_process	proteolysis
b	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
b	0009060	biological_process	aerobic respiration
b	0030061	cellular_component	mitochondrial crista
b	0045333	biological_process	cellular respiration
b	0046872	molecular_function	metal ion binding
b	0070469	cellular_component	respirasome
b	1902600	biological_process	proton transmembrane transport
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005750	cellular_component	mitochondrial respiratory chain complex III
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006508	biological_process	proteolysis
B	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
B	0009060	biological_process	aerobic respiration
B	0030061	cellular_component	mitochondrial crista
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	0070469	cellular_component	respirasome
B	1902600	biological_process	proton transmembrane transport
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0005750	cellular_component	mitochondrial respiratory chain complex III
c	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
c	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
c	0009060	biological_process	aerobic respiration
c	0016020	cellular_component	membrane
c	0016491	molecular_function	oxidoreductase activity
c	0045333	biological_process	cellular respiration
c	0046872	molecular_function	metal ion binding
c	0051537	molecular_function	2 iron, 2 sulfur cluster binding
c	0070469	cellular_component	respirasome
c	1902600	biological_process	proton transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005750	cellular_component	mitochondrial respiratory chain complex III
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009060	biological_process	aerobic respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0045333	biological_process	cellular respiration
C	0046872	molecular_function	metal ion binding
C	0051537	molecular_function	2 iron, 2 sulfur cluster binding
C	0070469	cellular_component	respirasome
C	1902600	biological_process	proton transmembrane transport
e	0005739	cellular_component	mitochondrion
e	0005743	cellular_component	mitochondrial inner membrane
e	0005750	cellular_component	mitochondrial respiratory chain complex III
e	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
e	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
e	0009060	biological_process	aerobic respiration
e	0034551	biological_process	mitochondrial respiratory chain complex III assembly
e	0045333	biological_process	cellular respiration
e	0070469	cellular_component	respirasome
e	1902600	biological_process	proton transmembrane transport
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005750	cellular_component	mitochondrial respiratory chain complex III
E	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0009060	biological_process	aerobic respiration
E	0034551	biological_process	mitochondrial respiratory chain complex III assembly
E	0045333	biological_process	cellular respiration
E	0070469	cellular_component	respirasome
E	1902600	biological_process	proton transmembrane transport
f	0005739	cellular_component	mitochondrion
f	0005743	cellular_component	mitochondrial inner membrane
f	0005750	cellular_component	mitochondrial respiratory chain complex III
f	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
f	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
f	0009060	biological_process	aerobic respiration
f	0034551	biological_process	mitochondrial respiratory chain complex III assembly
f	0045333	biological_process	cellular respiration
f	0070469	cellular_component	respirasome
f	0099617	cellular_component	matrix side of mitochondrial inner membrane
f	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005750	cellular_component	mitochondrial respiratory chain complex III
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
F	0009060	biological_process	aerobic respiration
F	0034551	biological_process	mitochondrial respiratory chain complex III assembly
F	0045333	biological_process	cellular respiration
F	0070469	cellular_component	respirasome
F	0099617	cellular_component	matrix side of mitochondrial inner membrane
F	1902600	biological_process	proton transmembrane transport
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0005750	cellular_component	mitochondrial respiratory chain complex III
g	0005758	cellular_component	mitochondrial intermembrane space
g	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
g	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
g	0009060	biological_process	aerobic respiration
g	0034399	cellular_component	nuclear periphery
g	0045333	biological_process	cellular respiration
g	0070469	cellular_component	respirasome
g	1902600	biological_process	proton transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005750	cellular_component	mitochondrial respiratory chain complex III
G	0005758	cellular_component	mitochondrial intermembrane space
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
G	0009060	biological_process	aerobic respiration
G	0034399	cellular_component	nuclear periphery
G	0045333	biological_process	cellular respiration
G	0070469	cellular_component	respirasome
G	1902600	biological_process	proton transmembrane transport
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0005750	cellular_component	mitochondrial respiratory chain complex III
h	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
h	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
h	0009060	biological_process	aerobic respiration
h	0045333	biological_process	cellular respiration
h	0070469	cellular_component	respirasome
h	1902600	biological_process	proton transmembrane transport
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005750	cellular_component	mitochondrial respiratory chain complex III
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
H	0009060	biological_process	aerobic respiration
H	0045333	biological_process	cellular respiration
H	0070469	cellular_component	respirasome
H	1902600	biological_process	proton transmembrane transport
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0005750	cellular_component	mitochondrial respiratory chain complex III
j	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
j	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
j	0009055	molecular_function	electron transfer activity
j	0009060	biological_process	aerobic respiration
j	0016020	cellular_component	membrane
j	0016491	molecular_function	oxidoreductase activity
j	0022904	biological_process	respiratory electron transport chain
j	0045275	cellular_component	respiratory chain complex III
j	0045333	biological_process	cellular respiration
j	0046872	molecular_function	metal ion binding
j	0070469	cellular_component	respirasome
j	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0005750	cellular_component	mitochondrial respiratory chain complex III
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
J	0009055	molecular_function	electron transfer activity
J	0009060	biological_process	aerobic respiration
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0022904	biological_process	respiratory electron transport chain
J	0045275	cellular_component	respiratory chain complex III
J	0045333	biological_process	cellular respiration
J	0046872	molecular_function	metal ion binding
J	0070469	cellular_component	respirasome
J	1902600	biological_process	proton transmembrane transport
K	0004129	molecular_function	cytochrome-c oxidase activity
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005751	cellular_component	mitochondrial respiratory chain complex IV
K	0006119	biological_process	oxidative phosphorylation
K	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
K	0009060	biological_process	aerobic respiration
K	0015990	biological_process	electron transport coupled proton transport
K	0016020	cellular_component	membrane
K	0020037	molecular_function	heme binding
K	0031966	cellular_component	mitochondrial membrane
K	0045277	cellular_component	respiratory chain complex IV
K	0045333	biological_process	cellular respiration
K	0046872	molecular_function	metal ion binding
K	0070469	cellular_component	respirasome
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0005750	cellular_component	mitochondrial respiratory chain complex III
l	0005758	cellular_component	mitochondrial intermembrane space
l	0005829	cellular_component	cytosol
l	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
l	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
l	0009055	molecular_function	electron transfer activity
l	0020037	molecular_function	heme binding
l	0045333	biological_process	cellular respiration
l	0046872	molecular_function	metal ion binding
l	0070469	cellular_component	respirasome
l	1902600	biological_process	proton transmembrane transport
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005750	cellular_component	mitochondrial respiratory chain complex III
L	0005758	cellular_component	mitochondrial intermembrane space
L	0005829	cellular_component	cytosol
L	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
L	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
L	0009055	molecular_function	electron transfer activity
L	0020037	molecular_function	heme binding
L	0045333	biological_process	cellular respiration
L	0046872	molecular_function	metal ion binding
L	0070469	cellular_component	respirasome
L	1902600	biological_process	proton transmembrane transport
M	0004129	molecular_function	cytochrome-c oxidase activity
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005751	cellular_component	mitochondrial respiratory chain complex IV
M	0006119	biological_process	oxidative phosphorylation
M	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
M	0016491	molecular_function	oxidoreductase activity
M	0045277	cellular_component	respiratory chain complex IV
M	1902600	biological_process	proton transmembrane transport
N	0004129	molecular_function	cytochrome-c oxidase activity
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005751	cellular_component	mitochondrial respiratory chain complex IV
N	0006119	biological_process	oxidative phosphorylation
N	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
N	0016491	molecular_function	oxidoreductase activity
N	0031966	cellular_component	mitochondrial membrane
N	0045333	biological_process	cellular respiration
N	1902600	biological_process	proton transmembrane transport
O	0004129	molecular_function	cytochrome-c oxidase activity
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005751	cellular_component	mitochondrial respiratory chain complex IV
O	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
O	0009055	molecular_function	electron transfer activity
O	0009060	biological_process	aerobic respiration
O	0016020	cellular_component	membrane
O	0019646	biological_process	aerobic electron transport chain
O	0022904	biological_process	respiratory electron transport chain
O	0031966	cellular_component	mitochondrial membrane
O	0045333	biological_process	cellular respiration
O	1902600	biological_process	proton transmembrane transport
P	0004129	molecular_function	cytochrome-c oxidase activity
P	0005507	molecular_function	copper ion binding
P	0005515	molecular_function	protein binding
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005751	cellular_component	mitochondrial respiratory chain complex IV
P	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
P	0009060	biological_process	aerobic respiration
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0022900	biological_process	electron transport chain
P	0042773	biological_process	ATP synthesis coupled electron transport
P	0046872	molecular_function	metal ion binding
P	0070469	cellular_component	respirasome
P	1902600	biological_process	proton transmembrane transport
Q	0004129	molecular_function	cytochrome-c oxidase activity
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005751	cellular_component	mitochondrial respiratory chain complex IV
Q	0006119	biological_process	oxidative phosphorylation
Q	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Q	0016491	molecular_function	oxidoreductase activity
Q	0046872	molecular_function	metal ion binding
Q	1902600	biological_process	proton transmembrane transport
R	0004129	molecular_function	cytochrome-c oxidase activity
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005751	cellular_component	mitochondrial respiratory chain complex IV
R	0006119	biological_process	oxidative phosphorylation
R	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
R	0016491	molecular_function	oxidoreductase activity
R	1902600	biological_process	proton transmembrane transport
S	0004129	molecular_function	cytochrome-c oxidase activity
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005751	cellular_component	mitochondrial respiratory chain complex IV
S	0006119	biological_process	oxidative phosphorylation
S	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
S	0009060	biological_process	aerobic respiration
S	0016491	molecular_function	oxidoreductase activity
S	0030234	molecular_function	enzyme regulator activity
S	0097250	biological_process	mitochondrial respirasome assembly
S	1902600	biological_process	proton transmembrane transport
T	0004129	molecular_function	cytochrome-c oxidase activity
T	0005739	cellular_component	mitochondrion
T	0005740	cellular_component	mitochondrial envelope
T	0005743	cellular_component	mitochondrial inner membrane
T	0005751	cellular_component	mitochondrial respiratory chain complex IV
T	0005758	cellular_component	mitochondrial intermembrane space
T	0006119	biological_process	oxidative phosphorylation
T	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
T	0008270	molecular_function	zinc ion binding
T	0016491	molecular_function	oxidoreductase activity
T	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
T	0046872	molecular_function	metal ion binding
T	1902600	biological_process	proton transmembrane transport
U	0004129	molecular_function	cytochrome-c oxidase activity
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005751	cellular_component	mitochondrial respiratory chain complex IV
U	0005758	cellular_component	mitochondrial intermembrane space
U	0006119	biological_process	oxidative phosphorylation
U	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
U	0016491	molecular_function	oxidoreductase activity
U	0031966	cellular_component	mitochondrial membrane
U	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
U	0045277	cellular_component	respiratory chain complex IV
U	0045333	biological_process	cellular respiration
U	1902600	biological_process	proton transmembrane transport
V	0003674	molecular_function	molecular_function
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0005746	cellular_component	mitochondrial respirasome
V	0005751	cellular_component	mitochondrial respiratory chain complex IV
V	0008150	biological_process	biological_process
W	0004129	molecular_function	cytochrome-c oxidase activity
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005751	cellular_component	mitochondrial respiratory chain complex IV
W	0005758	cellular_component	mitochondrial intermembrane space
W	0006119	biological_process	oxidative phosphorylation
W	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
W	0016491	molecular_function	oxidoreductase activity
W	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiliipgfgiishvvstyskkpvfgeismvyamasigllgflvws..HH

Chain	Residue	Details
K	TRP237-HIS291

---

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHdfaipslgikvdatpgrlnqvsaliqregvfyga......CselCgtgHanM

Chain	Residue	Details
P	VAL184-MET232

---

site_id	PS00143
Number of Residues	23
Details	INSULINASE Insulinase family, zinc-binding region signature. Ggsryatkd.GvAHLLNRFnFqNT

Chain	Residue	Details
B	GLY37-THR59

---

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. IMWlkptvnevarCweCGsvYKL

Chain	Residue	Details
T	ILE121-LEU143

---

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRsKpFfWGDGdKTlFwN

Chain	Residue	Details
S	ILE101-ASN118

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	67
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:30598554

Chain	Residue	Details
W	ALA21-ASN88
j	ILE365-LYS385
T	HIS119
T	CYS134
T	CYS137
K	HIS328-ALA335
K	LEU401-ASN406
K	GLN475-SER534
j	GLY205-SER223
j	ASP309-LYS319

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	TRANSMEM: Helical => ECO:0000269|PubMed:30598554

Chain	Residue	Details
W	LYS89-ALA111
j	GLY75-TYR102
j	VAL111-VAL135
j	ASN173-HIS204
j	TYR224-TYR246
j	LYS288-THR308
j	VAL320-GLY340
j	TYR348-LEU364
l	HIS263-LYS296
J	VAL111-VAL135
J	ASN173-HIS204
J	TYR224-TYR246
J	LYS288-THR308
J	VAL320-GLY340
J	TYR348-LEU364
j	TYR28-ALA51

---

site_id	SWS_FT_FI3
Number of Residues	41
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:30598554

Chain	Residue	Details
W	VAL112-LYS153
O	SER115-LEU137
O	TYR189-TYR201
O	TRP266-VAL269
K	ALA359-THR370
K	GLY432-GLY449
j	SER247-ASP287
j	ALA341-PRO347

---

site_id	SWS_FT_FI4
Number of Residues	29
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
P	GLN79-ASP108
L	CYS104
l	CYS101
l	CYS104
c	CYS159
c	HIS161
c	CYS178
c	HIS181

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:30598554

Chain	Residue	Details
P	HIS186
P	CYS221
P	CYS225
P	MET232
j	HIS82
j	HIS96
j	HIS183
j	HIS197

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:30598554, ECO:0000269|PubMed:30598556

Chain	Residue	Details
P	GLU223
P	HIS229

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Cleavage; by IMP1 => ECO:0000269|PubMed:8879245

Chain	Residue	Details
P	ASN15

---

site_id	SWS_FT_FI8
Number of Residues	28
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
O	GLY202-MET230

---

site_id	SWS_FT_FI9
Number of Residues	16
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
O	TYR249-TYR265

---

site_id	SWS_FT_FI10
Number of Residues	28
Details	TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
K	ALA299-ILE327

---

site_id	SWS_FT_FI11
Number of Residues	22
Details	TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
K	THR336-LEU358

---

site_id	SWS_FT_FI12
Number of Residues	29
Details	TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
K	TYR371-ILE400

---

site_id	SWS_FT_FI13
Number of Residues	24
Details	TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
K	GLU407-LEU431

---

site_id	SWS_FT_FI14
Number of Residues	24
Details	TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:30598554

Chain	Residue	Details
K	TRP450-ASP474

---

site_id	SWS_FT_FI15
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:30598554, ECO:0000269|PubMed:30598556

Chain	Residue	Details
K	GLU39
K	ALA42
K	GLY44
K	HIS241
K	HIS290
K	HIS291
K	HIS368
K	ASP369
K	PRO441

---

site_id	SWS_FT_FI16
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269|PubMed:30598554, ECO:0000269|PubMed:30598556

Chain	Residue	Details
K	HIS62
K	HIS378

---

site_id	SWS_FT_FI17
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
K	TYR245

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site_id	SWS_FT_FI18
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269|PubMed:30598554

Chain	Residue	Details
K	HIS376

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site_id	SWS_FT_FI19
Number of Residues	2
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:30598554

Chain	Residue	Details
K	HIS241
K	TYR245

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 208

Chain	Residue	Details
J	HIS202	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
J	SER206	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
J	LYS228	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
J	ASP229	electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
J	GLU272	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

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site_id	MCSA2
Number of Residues	5
Details	M-CSA 208

Chain	Residue	Details
j	HIS202	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
j	SER206	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
j	LYS228	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
j	ASP229	electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
j	GLU272	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

---