8EC0

III2IV respiratory supercomplex from Saccharomyces cerevisiae cardiolipin-lacking mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
A	0008121	molecular_function	quinol-cytochrome-c reductase activity
A	0009060	biological_process	aerobic respiration
A	0017087	cellular_component	mitochondrial processing peptidase complex
A	0022904	biological_process	respiratory electron transport chain
A	0045275	cellular_component	respiratory chain complex III
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006508	biological_process	proteolysis
B	0008121	molecular_function	quinol-cytochrome-c reductase activity
B	0009060	biological_process	aerobic respiration
B	0016020	cellular_component	membrane
B	0022904	biological_process	respiratory electron transport chain
B	0030061	cellular_component	mitochondrial crista
B	0045275	cellular_component	respiratory chain complex III
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	quinol-cytochrome-c reductase activity
C	0009060	biological_process	aerobic respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0022904	biological_process	respiratory electron transport chain
C	0045275	cellular_component	respiratory chain complex III
C	0045333	biological_process	cellular respiration
C	0046872	molecular_function	metal ion binding
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051537	molecular_function	2 iron, 2 sulfur cluster binding
C	1902600	biological_process	proton transmembrane transport
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
E	0008121	molecular_function	quinol-cytochrome-c reductase activity
E	0009060	biological_process	aerobic respiration
E	0016020	cellular_component	membrane
E	0022904	biological_process	respiratory electron transport chain
E	0034551	biological_process	mitochondrial respiratory chain complex III assembly
E	0045275	cellular_component	respiratory chain complex III
E	0045333	biological_process	cellular respiration
E	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0008121	molecular_function	quinol-cytochrome-c reductase activity
F	0009060	biological_process	aerobic respiration
F	0016020	cellular_component	membrane
F	0022904	biological_process	respiratory electron transport chain
F	0034551	biological_process	mitochondrial respiratory chain complex III assembly
F	0045275	cellular_component	respiratory chain complex III
F	0045333	biological_process	cellular respiration
F	0099617	cellular_component	matrix side of mitochondrial inner membrane
F	1902600	biological_process	proton transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005758	cellular_component	mitochondrial intermembrane space
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0008121	molecular_function	quinol-cytochrome-c reductase activity
G	0009060	biological_process	aerobic respiration
G	0016020	cellular_component	membrane
G	0022904	biological_process	respiratory electron transport chain
G	0034399	cellular_component	nuclear periphery
G	0045275	cellular_component	respiratory chain complex III
G	0045333	biological_process	cellular respiration
G	1902600	biological_process	proton transmembrane transport
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0008121	molecular_function	quinol-cytochrome-c reductase activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0022904	biological_process	respiratory electron transport chain
H	0045275	cellular_component	respiratory chain complex III
H	0045333	biological_process	cellular respiration
H	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0008121	molecular_function	quinol-cytochrome-c reductase activity
J	0009055	molecular_function	electron transfer activity
J	0009060	biological_process	aerobic respiration
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0022904	biological_process	respiratory electron transport chain
J	0045275	cellular_component	respiratory chain complex III
J	0045333	biological_process	cellular respiration
J	0046872	molecular_function	metal ion binding
J	1902600	biological_process	proton transmembrane transport
K	0004129	molecular_function	cytochrome-c oxidase activity
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0006119	biological_process	oxidative phosphorylation
K	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
K	0009060	biological_process	aerobic respiration
K	0016020	cellular_component	membrane
K	0020037	molecular_function	heme binding
K	0022904	biological_process	respiratory electron transport chain
K	0031966	cellular_component	mitochondrial membrane
K	0045277	cellular_component	respiratory chain complex IV
K	0045333	biological_process	cellular respiration
K	0046872	molecular_function	metal ion binding
K	1902600	biological_process	proton transmembrane transport
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005758	cellular_component	mitochondrial intermembrane space
L	0005829	cellular_component	cytosol
L	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
L	0008121	molecular_function	quinol-cytochrome-c reductase activity
L	0009055	molecular_function	electron transfer activity
L	0016020	cellular_component	membrane
L	0020037	molecular_function	heme binding
L	0022904	biological_process	respiratory electron transport chain
L	0045275	cellular_component	respiratory chain complex III
L	0045333	biological_process	cellular respiration
L	0046872	molecular_function	metal ion binding
L	1902600	biological_process	proton transmembrane transport
M	0004129	molecular_function	cytochrome-c oxidase activity
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0006119	biological_process	oxidative phosphorylation
M	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
M	0016491	molecular_function	oxidoreductase activity
M	0045277	cellular_component	respiratory chain complex IV
M	1902600	biological_process	proton transmembrane transport
N	0004129	molecular_function	cytochrome-c oxidase activity
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006119	biological_process	oxidative phosphorylation
N	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
N	0016491	molecular_function	oxidoreductase activity
N	0031966	cellular_component	mitochondrial membrane
N	0045277	cellular_component	respiratory chain complex IV
N	0045333	biological_process	cellular respiration
N	1902600	biological_process	proton transmembrane transport
O	0004129	molecular_function	cytochrome-c oxidase activity
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
O	0009055	molecular_function	electron transfer activity
O	0009060	biological_process	aerobic respiration
O	0016020	cellular_component	membrane
O	0019646	biological_process	aerobic electron transport chain
O	0022904	biological_process	respiratory electron transport chain
O	0031966	cellular_component	mitochondrial membrane
O	0045277	cellular_component	respiratory chain complex IV
O	0045333	biological_process	cellular respiration
O	0048039	molecular_function	ubiquinone binding
O	1902600	biological_process	proton transmembrane transport
P	0004129	molecular_function	cytochrome-c oxidase activity
P	0005507	molecular_function	copper ion binding
P	0005515	molecular_function	protein binding
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
P	0009060	biological_process	aerobic respiration
P	0016020	cellular_component	membrane
P	0016491	molecular_function	oxidoreductase activity
P	0022900	biological_process	electron transport chain
P	0022904	biological_process	respiratory electron transport chain
P	0031966	cellular_component	mitochondrial membrane
P	0042773	biological_process	ATP synthesis coupled electron transport
P	0045277	cellular_component	respiratory chain complex IV
P	0046872	molecular_function	metal ion binding
P	1902600	biological_process	proton transmembrane transport
Q	0004129	molecular_function	cytochrome-c oxidase activity
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0006119	biological_process	oxidative phosphorylation
Q	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Q	0016491	molecular_function	oxidoreductase activity
Q	0045277	cellular_component	respiratory chain complex IV
Q	0046872	molecular_function	metal ion binding
Q	1902600	biological_process	proton transmembrane transport
R	0004129	molecular_function	cytochrome-c oxidase activity
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0006119	biological_process	oxidative phosphorylation
R	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
R	0016491	molecular_function	oxidoreductase activity
R	0045277	cellular_component	respiratory chain complex IV
R	1902600	biological_process	proton transmembrane transport
S	0004129	molecular_function	cytochrome-c oxidase activity
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0006119	biological_process	oxidative phosphorylation
S	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
S	0009060	biological_process	aerobic respiration
S	0016491	molecular_function	oxidoreductase activity
S	0030234	molecular_function	enzyme regulator activity
S	0045277	cellular_component	respiratory chain complex IV
S	0097250	biological_process	mitochondrial respirasome assembly
S	1902600	biological_process	proton transmembrane transport
T	0004129	molecular_function	cytochrome-c oxidase activity
T	0005515	molecular_function	protein binding
T	0005739	cellular_component	mitochondrion
T	0005740	cellular_component	mitochondrial envelope
T	0005743	cellular_component	mitochondrial inner membrane
T	0005758	cellular_component	mitochondrial intermembrane space
T	0006119	biological_process	oxidative phosphorylation
T	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
T	0008270	molecular_function	zinc ion binding
T	0016491	molecular_function	oxidoreductase activity
T	0033617	biological_process	mitochondrial respiratory chain complex IV assembly
T	0045277	cellular_component	respiratory chain complex IV
T	0046872	molecular_function	metal ion binding
T	1902600	biological_process	proton transmembrane transport
T	1990145	biological_process	maintenance of translational fidelity
U	0004129	molecular_function	cytochrome-c oxidase activity
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0005758	cellular_component	mitochondrial intermembrane space
U	0006119	biological_process	oxidative phosphorylation
U	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
U	0016491	molecular_function	oxidoreductase activity
U	0031966	cellular_component	mitochondrial membrane
U	0033617	biological_process	mitochondrial respiratory chain complex IV assembly
U	0045277	cellular_component	respiratory chain complex IV
U	0045333	biological_process	cellular respiration
U	1902600	biological_process	proton transmembrane transport
V	0003674	molecular_function	molecular_function
V	0005739	cellular_component	mitochondrion
V	0005743	cellular_component	mitochondrial inner membrane
V	0008150	biological_process	biological_process
V	0045277	cellular_component	respiratory chain complex IV
V	0098803	cellular_component	respiratory chain complex
W	0004129	molecular_function	cytochrome-c oxidase activity
W	0005515	molecular_function	protein binding
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0005758	cellular_component	mitochondrial intermembrane space
W	0006119	biological_process	oxidative phosphorylation
W	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
W	0016491	molecular_function	oxidoreductase activity
W	0045277	cellular_component	respiratory chain complex IV
W	1902600	biological_process	proton transmembrane transport
a	0004222	molecular_function	metalloendopeptidase activity
a	0005515	molecular_function	protein binding
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
a	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
a	0008121	molecular_function	quinol-cytochrome-c reductase activity
a	0009060	biological_process	aerobic respiration
a	0017087	cellular_component	mitochondrial processing peptidase complex
a	0022904	biological_process	respiratory electron transport chain
a	0045275	cellular_component	respiratory chain complex III
a	0045333	biological_process	cellular respiration
a	0046872	molecular_function	metal ion binding
a	1902600	biological_process	proton transmembrane transport
b	0004222	molecular_function	metalloendopeptidase activity
b	0005515	molecular_function	protein binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
b	0006508	biological_process	proteolysis
b	0008121	molecular_function	quinol-cytochrome-c reductase activity
b	0009060	biological_process	aerobic respiration
b	0016020	cellular_component	membrane
b	0022904	biological_process	respiratory electron transport chain
b	0030061	cellular_component	mitochondrial crista
b	0045275	cellular_component	respiratory chain complex III
b	0045333	biological_process	cellular respiration
b	0046872	molecular_function	metal ion binding
b	1902600	biological_process	proton transmembrane transport
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
c	0008121	molecular_function	quinol-cytochrome-c reductase activity
c	0009060	biological_process	aerobic respiration
c	0016020	cellular_component	membrane
c	0016491	molecular_function	oxidoreductase activity
c	0022904	biological_process	respiratory electron transport chain
c	0045275	cellular_component	respiratory chain complex III
c	0045333	biological_process	cellular respiration
c	0046872	molecular_function	metal ion binding
c	0051536	molecular_function	iron-sulfur cluster binding
c	0051537	molecular_function	2 iron, 2 sulfur cluster binding
c	1902600	biological_process	proton transmembrane transport
e	0005739	cellular_component	mitochondrion
e	0005743	cellular_component	mitochondrial inner membrane
e	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
e	0008121	molecular_function	quinol-cytochrome-c reductase activity
e	0009060	biological_process	aerobic respiration
e	0016020	cellular_component	membrane
e	0022904	biological_process	respiratory electron transport chain
e	0034551	biological_process	mitochondrial respiratory chain complex III assembly
e	0045275	cellular_component	respiratory chain complex III
e	0045333	biological_process	cellular respiration
e	1902600	biological_process	proton transmembrane transport
f	0005739	cellular_component	mitochondrion
f	0005743	cellular_component	mitochondrial inner membrane
f	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
f	0008121	molecular_function	quinol-cytochrome-c reductase activity
f	0009060	biological_process	aerobic respiration
f	0016020	cellular_component	membrane
f	0022904	biological_process	respiratory electron transport chain
f	0034551	biological_process	mitochondrial respiratory chain complex III assembly
f	0045275	cellular_component	respiratory chain complex III
f	0045333	biological_process	cellular respiration
f	0099617	cellular_component	matrix side of mitochondrial inner membrane
f	1902600	biological_process	proton transmembrane transport
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0005758	cellular_component	mitochondrial intermembrane space
g	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
g	0008121	molecular_function	quinol-cytochrome-c reductase activity
g	0009060	biological_process	aerobic respiration
g	0016020	cellular_component	membrane
g	0022904	biological_process	respiratory electron transport chain
g	0034399	cellular_component	nuclear periphery
g	0045275	cellular_component	respiratory chain complex III
g	0045333	biological_process	cellular respiration
g	1902600	biological_process	proton transmembrane transport
h	0005739	cellular_component	mitochondrion
h	0005743	cellular_component	mitochondrial inner membrane
h	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
h	0008121	molecular_function	quinol-cytochrome-c reductase activity
h	0009060	biological_process	aerobic respiration
h	0016020	cellular_component	membrane
h	0022904	biological_process	respiratory electron transport chain
h	0045275	cellular_component	respiratory chain complex III
h	0045333	biological_process	cellular respiration
h	1902600	biological_process	proton transmembrane transport
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
j	0008121	molecular_function	quinol-cytochrome-c reductase activity
j	0009055	molecular_function	electron transfer activity
j	0009060	biological_process	aerobic respiration
j	0016020	cellular_component	membrane
j	0016491	molecular_function	oxidoreductase activity
j	0022904	biological_process	respiratory electron transport chain
j	0045275	cellular_component	respiratory chain complex III
j	0045333	biological_process	cellular respiration
j	0046872	molecular_function	metal ion binding
j	1902600	biological_process	proton transmembrane transport
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0005758	cellular_component	mitochondrial intermembrane space
l	0005829	cellular_component	cytosol
l	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
l	0008121	molecular_function	quinol-cytochrome-c reductase activity
l	0009055	molecular_function	electron transfer activity
l	0016020	cellular_component	membrane
l	0020037	molecular_function	heme binding
l	0022904	biological_process	respiratory electron transport chain
l	0045275	cellular_component	respiratory chain complex III
l	0045333	biological_process	cellular respiration
l	0046872	molecular_function	metal ion binding
l	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiliipgfgiishvvstyskkpvfgeismvyamasigllgflvws..HH

Chain	Residue	Details
K	TRP237-HIS291

---

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHdfaipslgikvdatpgrlnqvsaliqregvfyga......CselCgtgHanM

Chain	Residue	Details
P	VAL184-MET232

---

site_id	PS00143
Number of Residues	23
Details	INSULINASE Insulinase family, zinc-binding region signature. Ggsryatkd.GvAHLLNRFnFqNT

Chain	Residue	Details
B	GLY37-THR59

---

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. IMWlkptvnevarCweCGsvYKL

Chain	Residue	Details
T	ILE121-LEU143

---

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRsKpFfWGDGdKTlFwN

Chain	Residue	Details
S	ILE101-ASN118

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17761666","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	162
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	234
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	294
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	182
Details	Domain: {"description":"Rieske","evidences":[{"source":"PROSITE-ProRule","id":"PRU00628","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	6
Details	Region: {"description":"Hinge","evidences":[{"source":"PubMed","id":"30598556","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10873857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11880631","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KB9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KYO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P84","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PD4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	162
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031140","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	366
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"10873857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11880631","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CX5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	208
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8031140","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"10873857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11880631","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KB9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KYO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1P84","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IBZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CX5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CXH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PD4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	290
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	75
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	337
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	86
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	53
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	51
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	41
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=12","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	11
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598556","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598556","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	2
Details	Cross-link: {"description":"1'-histidyl-3'-tyrosine (His-Tyr)","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	400
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9430684","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	24
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9430684","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	306
Details	Domain: {"description":"Cytochrome c","evidences":[{"source":"PROSITE-ProRule","id":"PRU00433","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	74
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	18
Details	Compositional bias: {"description":"Acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI40
Number of Residues	4
Details	Binding site: {"description":"covalent","evidences":[{"source":"PubMed","id":"10873857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11880631","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KYO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI41
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"11880631","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KYO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI42
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"10873857","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11880631","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18390544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EZV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KYO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI43
Number of Residues	128
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI44
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17215247","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30598554","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI45
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17761666","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI46
Number of Residues	43
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI47
Number of Residues	10
Details	Motif: {"description":"Cx9C motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI48
Number of Residues	11
Details	Motif: {"description":"Cx10C motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 208

Chain	Residue	Details
C	HIS181	covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

---

site_id	MCSA2
Number of Residues	5
Details	M-CSA 208

Chain

Residue

Details

---