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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8EBV

Initial DNA-lesion (AP) binding by XPC and TFIIH complex 1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000112cellular_componentnucleotide-excision repair factor 3 complex
A0000166molecular_functionnucleotide binding
A0000439cellular_componenttranscription factor TFIIH core complex
A0003677molecular_functionDNA binding
A0003678molecular_functionDNA helicase activity
A0003684molecular_functiondamaged DNA binding
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005669cellular_componenttranscription factor TFIID complex
A0005675cellular_componenttranscription factor TFIIH holo complex
A0006265biological_processDNA topological change
A0006281biological_processDNA repair
A0006283biological_processtranscription-coupled nucleotide-excision repair
A0006289biological_processnucleotide-excision repair
A0006351biological_processDNA-templated transcription
A0006366biological_processtranscription by RNA polymerase II
A0006367biological_processtranscription initiation at RNA polymerase II promoter
A0006368biological_processtranscription elongation by RNA polymerase II
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0006979biological_processresponse to oxidative stress
A0008104biological_processintracellular protein localization
A0009411biological_processresponse to UV
A0016787molecular_functionhydrolase activity
A0016853molecular_functionisomerase activity
A0016887molecular_functionATP hydrolysis activity
A0035315biological_processhair cell differentiation
A0043065biological_processpositive regulation of apoptotic process
A0043138molecular_function3'-5' DNA helicase activity
A0048568biological_processembryonic organ development
A0097550cellular_componenttranscription preinitiation complex
A1901990biological_processregulation of mitotic cell cycle phase transition
A1990841molecular_functionpromoter-specific chromatin binding
B0000166molecular_functionnucleotide binding
B0000439cellular_componenttranscription factor TFIIH core complex
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003678molecular_functionDNA helicase activity
B0003684molecular_functiondamaged DNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005669cellular_componenttranscription factor TFIID complex
B0005675cellular_componenttranscription factor TFIIH holo complex
B0005737cellular_componentcytoplasm
B0005819cellular_componentspindle
B0006139biological_processnucleobase-containing compound metabolic process
B0006281biological_processDNA repair
B0006283biological_processtranscription-coupled nucleotide-excision repair
B0006289biological_processnucleotide-excision repair
B0006351biological_processDNA-templated transcription
B0006357biological_processregulation of transcription by RNA polymerase II
B0006366biological_processtranscription by RNA polymerase II
B0006367biological_processtranscription initiation at RNA polymerase II promoter
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0006979biological_processresponse to oxidative stress
B0007059biological_processchromosome segregation
B0016787molecular_functionhydrolase activity
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0016853molecular_functionisomerase activity
B0016887molecular_functionATP hydrolysis activity
B0030674molecular_functionprotein-macromolecule adaptor activity
B0035315biological_processhair cell differentiation
B0043139molecular_function5'-3' DNA helicase activity
B0045951biological_processpositive regulation of mitotic recombination
B0046872molecular_functionmetal ion binding
B0051536molecular_functioniron-sulfur cluster binding
B0051539molecular_function4 iron, 4 sulfur cluster binding
B0070516cellular_componentCAK-ERCC2 complex
B0071817cellular_componentMMXD complex
B1901990biological_processregulation of mitotic cell cycle phase transition
C0000079biological_processregulation of cyclin-dependent protein serine/threonine kinase activity
C0000439cellular_componenttranscription factor TFIIH core complex
C0003682molecular_functionchromatin binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005675cellular_componenttranscription factor TFIIH holo complex
C0006281biological_processDNA repair
C0006289biological_processnucleotide-excision repair
C0006351biological_processDNA-templated transcription
C0006360biological_processtranscription by RNA polymerase I
C0006366biological_processtranscription by RNA polymerase II
C0006367biological_processtranscription initiation at RNA polymerase II promoter
C0006974biological_processDNA damage response
C0009755biological_processhormone-mediated signaling pathway
C0045893biological_processpositive regulation of DNA-templated transcription
C0046966molecular_functionnuclear thyroid hormone receptor binding
D0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
D0000439cellular_componenttranscription factor TFIIH core complex
D0001671molecular_functionATPase activator activity
D0003690molecular_functiondouble-stranded DNA binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005669cellular_componenttranscription factor TFIID complex
D0005675cellular_componenttranscription factor TFIIH holo complex
D0006281biological_processDNA repair
D0006289biological_processnucleotide-excision repair
D0006351biological_processDNA-templated transcription
D0006366biological_processtranscription by RNA polymerase II
D0006367biological_processtranscription initiation at RNA polymerase II promoter
D0006974biological_processDNA damage response
D0016251molecular_functionRNA polymerase II general transcription initiation factor activity
D0016607cellular_componentnuclear speck
E0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
E0000439cellular_componenttranscription factor TFIIH core complex
E0002031biological_processG protein-coupled receptor internalization
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005669cellular_componenttranscription factor TFIID complex
E0005675cellular_componenttranscription factor TFIIH holo complex
E0006281biological_processDNA repair
E0006289biological_processnucleotide-excision repair
E0006351biological_processDNA-templated transcription
E0006357biological_processregulation of transcription by RNA polymerase II
E0006366biological_processtranscription by RNA polymerase II
E0006367biological_processtranscription initiation at RNA polymerase II promoter
E0006974biological_processDNA damage response
E0008270molecular_functionzinc ion binding
E0009411biological_processresponse to UV
E0016251molecular_functionRNA polymerase II general transcription initiation factor activity
E0016607cellular_componentnuclear speck
E0046872molecular_functionmetal ion binding
F0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
F0000439cellular_componenttranscription factor TFIIH core complex
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005669cellular_componenttranscription factor TFIID complex
F0005675cellular_componenttranscription factor TFIIH holo complex
F0006281biological_processDNA repair
F0006289biological_processnucleotide-excision repair
F0006351biological_processDNA-templated transcription
F0006355biological_processregulation of DNA-templated transcription
F0006366biological_processtranscription by RNA polymerase II
F0006367biological_processtranscription initiation at RNA polymerase II promoter
F0006974biological_processDNA damage response
F0008270molecular_functionzinc ion binding
F0016251molecular_functionRNA polymerase II general transcription initiation factor activity
F0046872molecular_functionmetal ion binding
F0097550cellular_componenttranscription preinitiation complex
G0000439cellular_componenttranscription factor TFIIH core complex
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005669cellular_componenttranscription factor TFIID complex
G0005675cellular_componenttranscription factor TFIIH holo complex
G0005730cellular_componentnucleolus
G0005737cellular_componentcytoplasm
G0006281biological_processDNA repair
G0006289biological_processnucleotide-excision repair
G0006294biological_processnucleotide-excision repair, preincision complex assembly
G0006351biological_processDNA-templated transcription
G0006366biological_processtranscription by RNA polymerase II
G0006367biological_processtranscription initiation at RNA polymerase II promoter
G0006974biological_processDNA damage response
H0000109cellular_componentnucleotide-excision repair complex
H0000111cellular_componentnucleotide-excision repair factor 2 complex
H0000404molecular_functionheteroduplex DNA loop binding
H0000405molecular_functionbubble DNA binding
H0000785cellular_componentchromatin
H0003677molecular_functionDNA binding
H0003684molecular_functiondamaged DNA binding
H0003697molecular_functionsingle-stranded DNA binding
H0003713molecular_functiontranscription coactivator activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005654cellular_componentnucleoplasm
H0005694cellular_componentchromosome
H0005737cellular_componentcytoplasm
H0005886cellular_componentplasma membrane
H0006281biological_processDNA repair
H0006289biological_processnucleotide-excision repair
H0006298biological_processmismatch repair
H0006351biological_processDNA-templated transcription
H0006974biological_processDNA damage response
H0007346biological_processregulation of mitotic cell cycle
H0009410biological_processresponse to xenobiotic stimulus
H0010996biological_processresponse to auditory stimulus
H0044877molecular_functionprotein-containing complex binding
H0045893biological_processpositive regulation of DNA-templated transcription
H0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
H0070914biological_processUV-damage excision repair
H0071942cellular_componentXPC complex
H0090734cellular_componentsite of DNA damage
H0140612molecular_functionDNA damage sensor activity
H1901987biological_processregulation of cell cycle phase transition
H1901990biological_processregulation of mitotic cell cycle phase transition
I0000502cellular_componentproteasome complex
I0000976molecular_functiontranscription cis-regulatory region binding
I0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
I0003684molecular_functiondamaged DNA binding
I0003697molecular_functionsingle-stranded DNA binding
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006281biological_processDNA repair
I0006289biological_processnucleotide-excision repair
I0006338biological_processchromatin remodeling
I0006974biological_processDNA damage response
I0016491molecular_functionoxidoreductase activity
I0031593molecular_functionpolyubiquitin modification-dependent protein binding
I0032434biological_processregulation of proteasomal ubiquitin-dependent protein catabolic process
I0035575molecular_functionhistone H4K20 demethylase activity
I0043130molecular_functionubiquitin binding
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0048568biological_processembryonic organ development
I0051213molecular_functiondioxygenase activity
I0061629molecular_functionRNA polymerase II-specific DNA-binding transcription factor binding
I0070628molecular_functionproteasome binding
I0071942cellular_componentXPC complex
I0140612molecular_functionDNA damage sensor activity
J0000226biological_processmicrotubule cytoskeleton organization
J0000278biological_processmitotic cell cycle
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005635cellular_componentnuclear envelope
J0005643cellular_componentnuclear pore
J0005654cellular_componentnucleoplasm
J0005813cellular_componentcentrosome
J0005814cellular_componentcentriole
J0005829cellular_componentcytosol
J0005929cellular_componentcilium
J0006281biological_processDNA repair
J0006289biological_processnucleotide-excision repair
J0006406biological_processmRNA export from nucleus
J0006974biological_processDNA damage response
J0007099biological_processcentriole replication
J0007283biological_processspermatogenesis
J0008017molecular_functionmicrotubule binding
J0015031biological_processprotein transport
J0031683molecular_functionG-protein beta/gamma-subunit complex binding
J0032391cellular_componentphotoreceptor connecting cilium
J0032465biological_processregulation of cytokinesis
J0032795molecular_functionheterotrimeric G-protein binding
J0036064cellular_componentciliary basal body
J0044615cellular_componentnuclear pore nuclear basket
J0045177cellular_componentapical part of cell
J0045944biological_processpositive regulation of transcription by RNA polymerase II
J0046872molecular_functionmetal ion binding
J0051028biological_processmRNA transport
J0051301biological_processcell division
J0070390cellular_componenttranscription export complex 2
J0071942cellular_componentXPC complex
J0097225cellular_componentsperm midpiece
J0097228cellular_componentsperm principal piece
J0097729cellular_component9+2 motile cilium
Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DADGTGTIDvkEL
ChainResidueDetails
JASP41-LEU53
JASP150-PHE162
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H
ChainResidueDetails
ECYS360-HIS380
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. MIDEADRdG
ChainResidueDetails
JMET145-GLY153
site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN
ChainResidueDetails
BALA229-ASN238
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues437
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues160
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsMotif: {"description":"DEVH box"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues199
DetailsRegion: {"description":"Mediates interaction with MMS19"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsMotif: {"description":"DEAH box"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues13
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues52
DetailsDomain: {"description":"BSD 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00036","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues176
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues34
DetailsZinc finger: {"description":"C4-type"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"A0JN27","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues159
DetailsRegion: {"description":"Minimal sensor domain involved in damage recognition"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues134
DetailsRegion: {"description":"DNA-binding; preference for heteroduplex DNA"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues64
DetailsRegion: {"description":"DNA-binding; preference for single stranded DNA; required for formation of stable nucleoprotein complex"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues19
DetailsRegion: {"description":"Interaction with CETN2"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues43
DetailsDomain: {"description":"STI1"}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues35
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues35
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues35
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues35
DetailsDomain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues10
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI28
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

248335

PDB entries from 2026-01-28

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