8EBU

XPC release from Core7-XPA-DNA (Cy5)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000112	cellular_component	nucleotide-excision repair factor 3 complex
A	0000166	molecular_function	nucleotide binding
A	0000439	cellular_component	transcription factor TFIIH core complex
A	0003677	molecular_function	DNA binding
A	0003678	molecular_function	DNA helicase activity
A	0003684	molecular_function	damaged DNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005669	cellular_component	transcription factor TFIID complex
A	0005675	cellular_component	transcription factor TFIIH holo complex
A	0006265	biological_process	DNA topological change
A	0006281	biological_process	DNA repair
A	0006283	biological_process	transcription-coupled nucleotide-excision repair
A	0006289	biological_process	nucleotide-excision repair
A	0006351	biological_process	DNA-templated transcription
A	0006366	biological_process	transcription by RNA polymerase II
A	0006367	biological_process	transcription initiation at RNA polymerase II promoter
A	0006368	biological_process	transcription elongation by RNA polymerase II
A	0006915	biological_process	apoptotic process
A	0006974	biological_process	DNA damage response
A	0006979	biological_process	response to oxidative stress
A	0008104	biological_process	intracellular protein localization
A	0009411	biological_process	response to UV
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0035315	biological_process	hair cell differentiation
A	0043065	biological_process	positive regulation of apoptotic process
A	0043138	molecular_function	3'-5' DNA helicase activity
A	0048568	biological_process	embryonic organ development
A	0097550	cellular_component	transcription preinitiation complex
A	1901990	biological_process	regulation of mitotic cell cycle phase transition
A	1990841	molecular_function	promoter-specific chromatin binding
B	0000166	molecular_function	nucleotide binding
B	0000439	cellular_component	transcription factor TFIIH core complex
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003678	molecular_function	DNA helicase activity
B	0003684	molecular_function	damaged DNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005669	cellular_component	transcription factor TFIID complex
B	0005675	cellular_component	transcription factor TFIIH holo complex
B	0005737	cellular_component	cytoplasm
B	0005819	cellular_component	spindle
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006281	biological_process	DNA repair
B	0006283	biological_process	transcription-coupled nucleotide-excision repair
B	0006289	biological_process	nucleotide-excision repair
B	0006351	biological_process	DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006366	biological_process	transcription by RNA polymerase II
B	0006367	biological_process	transcription initiation at RNA polymerase II promoter
B	0006915	biological_process	apoptotic process
B	0006974	biological_process	DNA damage response
B	0006979	biological_process	response to oxidative stress
B	0007059	biological_process	chromosome segregation
B	0016787	molecular_function	hydrolase activity
B	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0035315	biological_process	hair cell differentiation
B	0043139	molecular_function	5'-3' DNA helicase activity
B	0045951	biological_process	positive regulation of mitotic recombination
B	0046872	molecular_function	metal ion binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	0070516	cellular_component	CAK-ERCC2 complex
B	0071817	cellular_component	MMXD complex
B	1901990	biological_process	regulation of mitotic cell cycle phase transition
C	0000079	biological_process	regulation of cyclin-dependent protein serine/threonine kinase activity
C	0000439	cellular_component	transcription factor TFIIH core complex
C	0003682	molecular_function	chromatin binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005675	cellular_component	transcription factor TFIIH holo complex
C	0006281	biological_process	DNA repair
C	0006289	biological_process	nucleotide-excision repair
C	0006351	biological_process	DNA-templated transcription
C	0006360	biological_process	transcription by RNA polymerase I
C	0006366	biological_process	transcription by RNA polymerase II
C	0006367	biological_process	transcription initiation at RNA polymerase II promoter
C	0006974	biological_process	DNA damage response
C	0009755	biological_process	hormone-mediated signaling pathway
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0046966	molecular_function	nuclear thyroid hormone receptor binding
D	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
D	0000439	cellular_component	transcription factor TFIIH core complex
D	0001671	molecular_function	ATPase activator activity
D	0003690	molecular_function	double-stranded DNA binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005669	cellular_component	transcription factor TFIID complex
D	0005675	cellular_component	transcription factor TFIIH holo complex
D	0006281	biological_process	DNA repair
D	0006289	biological_process	nucleotide-excision repair
D	0006351	biological_process	DNA-templated transcription
D	0006366	biological_process	transcription by RNA polymerase II
D	0006367	biological_process	transcription initiation at RNA polymerase II promoter
D	0006974	biological_process	DNA damage response
D	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
D	0016607	cellular_component	nuclear speck
E	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
E	0000439	cellular_component	transcription factor TFIIH core complex
E	0002031	biological_process	G protein-coupled receptor internalization
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005669	cellular_component	transcription factor TFIID complex
E	0005675	cellular_component	transcription factor TFIIH holo complex
E	0006281	biological_process	DNA repair
E	0006289	biological_process	nucleotide-excision repair
E	0006351	biological_process	DNA-templated transcription
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006366	biological_process	transcription by RNA polymerase II
E	0006367	biological_process	transcription initiation at RNA polymerase II promoter
E	0006974	biological_process	DNA damage response
E	0008270	molecular_function	zinc ion binding
E	0009411	biological_process	response to UV
E	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
E	0016607	cellular_component	nuclear speck
E	0046872	molecular_function	metal ion binding
F	0000438	cellular_component	core TFIIH complex portion of holo TFIIH complex
F	0000439	cellular_component	transcription factor TFIIH core complex
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005669	cellular_component	transcription factor TFIID complex
F	0005675	cellular_component	transcription factor TFIIH holo complex
F	0006281	biological_process	DNA repair
F	0006289	biological_process	nucleotide-excision repair
F	0006351	biological_process	DNA-templated transcription
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006366	biological_process	transcription by RNA polymerase II
F	0006367	biological_process	transcription initiation at RNA polymerase II promoter
F	0006974	biological_process	DNA damage response
F	0008270	molecular_function	zinc ion binding
F	0016251	molecular_function	RNA polymerase II general transcription initiation factor activity
F	0046872	molecular_function	metal ion binding
F	0097550	cellular_component	transcription preinitiation complex
G	0000439	cellular_component	transcription factor TFIIH core complex
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005669	cellular_component	transcription factor TFIID complex
G	0005675	cellular_component	transcription factor TFIIH holo complex
G	0005730	cellular_component	nucleolus
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006289	biological_process	nucleotide-excision repair
G	0006294	biological_process	nucleotide-excision repair, preincision complex assembly
G	0006351	biological_process	DNA-templated transcription
G	0006366	biological_process	transcription by RNA polymerase II
G	0006367	biological_process	transcription initiation at RNA polymerase II promoter
G	0006974	biological_process	DNA damage response
H	0000109	cellular_component	nucleotide-excision repair complex
H	0000111	cellular_component	nucleotide-excision repair factor 2 complex
H	0000404	molecular_function	heteroduplex DNA loop binding
H	0000405	molecular_function	bubble DNA binding
H	0000785	cellular_component	chromatin
H	0003677	molecular_function	DNA binding
H	0003684	molecular_function	damaged DNA binding
H	0003697	molecular_function	single-stranded DNA binding
H	0003713	molecular_function	transcription coactivator activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005694	cellular_component	chromosome
H	0005737	cellular_component	cytoplasm
H	0005886	cellular_component	plasma membrane
H	0006281	biological_process	DNA repair
H	0006289	biological_process	nucleotide-excision repair
H	0006298	biological_process	mismatch repair
H	0006351	biological_process	DNA-templated transcription
H	0006974	biological_process	DNA damage response
H	0007346	biological_process	regulation of mitotic cell cycle
H	0009410	biological_process	response to xenobiotic stimulus
H	0010996	biological_process	response to auditory stimulus
H	0044877	molecular_function	protein-containing complex binding
H	0045893	biological_process	positive regulation of DNA-templated transcription
H	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
H	0070914	biological_process	UV-damage excision repair
H	0071942	cellular_component	XPC complex
H	0090734	cellular_component	site of DNA damage
H	0140612	molecular_function	DNA damage sensor activity
H	1901987	biological_process	regulation of cell cycle phase transition
H	1901990	biological_process	regulation of mitotic cell cycle phase transition
K	0000110	cellular_component	nucleotide-excision repair factor 1 complex
K	0000715	biological_process	nucleotide-excision repair, DNA damage recognition
K	0003677	molecular_function	DNA binding
K	0003684	molecular_function	damaged DNA binding
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005662	cellular_component	DNA replication factor A complex
K	0006281	biological_process	DNA repair
K	0006284	biological_process	base-excision repair
K	0006289	biological_process	nucleotide-excision repair
K	0006974	biological_process	DNA damage response
K	0008270	molecular_function	zinc ion binding
K	0009650	biological_process	UV protection
K	0016604	cellular_component	nuclear body
K	0019904	molecular_function	protein domain specific binding
K	0034504	biological_process	protein localization to nucleus
K	0042803	molecular_function	protein homodimerization activity
K	0046872	molecular_function	metal ion binding
K	0070914	biological_process	UV-damage excision repair
K	1901255	biological_process	nucleotide-excision repair involved in interstrand cross-link repair
K	1990837	molecular_function	sequence-specific double-stranded DNA binding

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H

Chain	Residue	Details
E	CYS360-HIS380

---

site_id	PS00690
Number of Residues	10
Details	DEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN

Chain	Residue	Details
B	ALA229-ASN238

---

site_id	PS00752
Number of Residues	25
Details	XPA_1 XPA protein signature 1. CeECgkeFm.DsyLmnhFdlptCdnC

Chain	Residue	Details
K	CYS105-CYS129

---

site_id	PS00753
Number of Residues	17
Details	XPA_2 XPA protein signature 2. LITKTEaKqEYLLkDcD

Chain	Residue	Details
K	LEU138-ASP154

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	161
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Motif: {"description":"DEVH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	199
Details	Region: {"description":"Mediates interaction with MMS19"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Motif: {"description":"DEAH box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	13
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	176
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	34
Details	Zinc finger: {"description":"C4-type"}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"A0JN27","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	24
Details	Zinc finger: {"evidences":[{"source":"PubMed","id":"2234061","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D4U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XPA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16540648","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---