Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8E9G

Mycobacterial respiratory complex I with both quinone positions modelled

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
A	0030964	cellular_component	NADH dehydrogenase complex
A	0048038	molecular_function	quinone binding
A	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
A	1902600	biological_process	proton transmembrane transport
B	0005506	molecular_function	iron ion binding
B	0005886	cellular_component	plasma membrane
B	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
B	0046872	molecular_function	metal ion binding
B	0048038	molecular_function	quinone binding
B	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051539	molecular_function	4 iron, 4 sulfur cluster binding
B	1902600	biological_process	proton transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
C	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
C	0048038	molecular_function	quinone binding
C	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
C	1902600	biological_process	proton transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
D	0048038	molecular_function	quinone binding
D	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
D	0051287	molecular_function	NAD binding
E	0003954	molecular_function	NADH dehydrogenase activity
E	0016491	molecular_function	oxidoreductase activity
E	0045271	cellular_component	respiratory chain complex I
E	0045272	cellular_component	obsolete plasma membrane respiratory chain complex I
E	0046872	molecular_function	metal ion binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
F	0010181	molecular_function	FMN binding
F	0016491	molecular_function	oxidoreductase activity
F	0045271	cellular_component	respiratory chain complex I
F	0046872	molecular_function	metal ion binding
F	0048038	molecular_function	quinone binding
F	0051287	molecular_function	NAD binding
F	0051539	molecular_function	4 iron, 4 sulfur cluster binding
F	1902600	biological_process	proton transmembrane transport
G	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
G	0042773	biological_process	ATP synthesis coupled electron transport
G	0043546	molecular_function	molybdopterin cofactor binding
G	0046872	molecular_function	metal ion binding
G	0048038	molecular_function	quinone binding
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
G	0051539	molecular_function	4 iron, 4 sulfur cluster binding
G	1902600	biological_process	proton transmembrane transport
H	0005886	cellular_component	plasma membrane
H	0016020	cellular_component	membrane
H	0016655	molecular_function	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
H	0048038	molecular_function	quinone binding
I	0005506	molecular_function	iron ion binding
I	0005886	cellular_component	plasma membrane
I	0016020	cellular_component	membrane
I	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
I	0046872	molecular_function	metal ion binding
I	0048038	molecular_function	quinone binding
I	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
I	0051539	molecular_function	4 iron, 4 sulfur cluster binding
J	0005886	cellular_component	plasma membrane
J	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
J	0048038	molecular_function	quinone binding
J	1902600	biological_process	proton transmembrane transport
K	0005886	cellular_component	plasma membrane
K	0016651	molecular_function	oxidoreductase activity, acting on NAD(P)H
K	0030964	cellular_component	NADH dehydrogenase complex
K	0042773	biological_process	ATP synthesis coupled electron transport
K	0048038	molecular_function	quinone binding
K	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
L	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0042773	biological_process	ATP synthesis coupled electron transport
L	1902600	biological_process	proton transmembrane transport
M	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
M	0016020	cellular_component	membrane
M	0016491	molecular_function	oxidoreductase activity
M	0042773	biological_process	ATP synthesis coupled electron transport
M	1902600	biological_process	proton transmembrane transport
N	0005886	cellular_component	plasma membrane
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0016491	molecular_function	oxidoreductase activity
N	0042773	biological_process	ATP synthesis coupled electron transport
N	0048038	molecular_function	quinone binding
N	0050136	molecular_function	NADH:ubiquinone reductase (non-electrogenic) activity
N	1902600	biological_process	proton transmembrane transport
O	0000160	biological_process	phosphorelay signal transduction system

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTTvM

Chain	Residue	Details
G	ALA74-MET81

site_id	PS00198
Number of Residues	12
Details	4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiGCElCAwACP

Chain	Residue	Details
I	CYS54-PRO65
I	CYS99-PRO110

site_id	PS00535
Number of Residues	12
Details	COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHTGiEKNlEyR

Chain	Residue	Details
D	LEU77-ARG88

site_id	PS00641
Number of Residues	18
Details	COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PrfCDhplldpvGaCRqC

Chain	Residue	Details
G	PRO45-CYS62

site_id	PS00642
Number of Residues	13
Details	COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPiCDkGGeCpLQ

Chain	Residue	Details
G	CYS114-GLN126

site_id	PS00643
Number of Residues	11
Details	COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCVlCaRCTrF

Chain	Residue	Details
G	ARG162-PHE172

site_id	PS00644
Number of Residues	16
Details	COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALLDS

Chain	Residue	Details
F	GLY175-SER190

site_id	PS00645
Number of Residues	12
Details	COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGkCtPCReG

Chain	Residue	Details
F	GLU349-GLY360

site_id	PS00667
Number of Residues	16
Details	COMPLEX1_ND1_1 Respiratory-chain NADH dehydrogenase subunit 1 signature 1. GLLQsLaDGIKLAlKE

Chain	Residue	Details
H	GLY59-GLU74

site_id	PS00668
Number of Residues	14
Details	COMPLEX1_ND1_2 Respiratory-chain NADH dehydrogenase subunit 1 signature 2. PFDLPEAEgeLVg.G

Chain	Residue	Details
H	PRO223-GLY236

site_id	PS00673
Number of Residues	11
Details	V8_SER Serine proteases, V8 family, serine active site. TsqGQSGStLY

Chain	Residue	Details
M	THR343-TYR353

site_id	PS01099
Number of Residues	19
Details	COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DgrVTlehveCNAaCdyAP

Chain	Residue	Details
E	ASP138-PRO156

site_id	PS01150
Number of Residues	17
Details	COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. GvDHVVPVDIYlPgCPP

Chain	Residue	Details
B	GLY118-PRO134

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	TRANSMEM: Helical => ECO:0000255\|HAMAP-Rule:MF_01456

Chain	Residue	Details
K	PRO3-LEU23
K	ILE28-PHE48
K	VAL59-ILE79
H	VAL165-THR185
H	THR198-GLU218
H	SER261-ILE281
H	TRP288-LEU308
H	MET321-ILE341
H	TRP353-ALA373

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)