8E7J
Cryo-EM structure of cardiac amyloid fibril from a variant ATTR I84S amyloidosis patient
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 15 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT |
Chain | Residue | Details |
A | LYS15 | |
D | LYS15 | |
D | GLU54 | |
D | SER117 | |
E | LYS15 | |
E | GLU54 | |
E | SER117 | |
A | GLU54 | |
A | SER117 | |
B | LYS15 | |
B | GLU54 | |
B | SER117 | |
C | LYS15 | |
C | GLU54 | |
C | SER117 |
site_id | SWS_FT_FI2 |
Number of Residues | 5 |
Details | MOD_RES: Sulfocysteine => ECO:0000269|PubMed:17175208, ECO:0007744|PDB:2H4E |
Chain | Residue | Details |
A | CYS10 | |
B | CYS10 | |
C | CYS10 | |
D | CYS10 | |
E | CYS10 |
site_id | SWS_FT_FI3 |
Number of Residues | 5 |
Details | MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012 |
Chain | Residue | Details |
A | GLU42 | |
B | GLU42 | |
C | GLU42 | |
D | GLU42 | |
E | GLU42 |
site_id | SWS_FT_FI4 |
Number of Residues | 5 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02767 |
Chain | Residue | Details |
A | SER52 | |
B | SER52 | |
C | SER52 | |
D | SER52 | |
E | SER52 |
site_id | SWS_FT_FI5 |
Number of Residues | 5 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19167329 |
Chain | Residue | Details |
A | ASN98 | |
B | ASN98 | |
C | ASN98 | |
D | ASN98 | |
E | ASN98 |