8E6O
Crystal structure of human GCN5 histone acetyltransferase domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0004402 | molecular_function | histone acetyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 27 |
| Details | Region: {"description":"Loop 3","evidences":[{"source":"PubMed","id":"29211711","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"27796307","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31527837","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 27 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29211711","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5TRL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23142079","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| A | PHE568 | electrostatic stabiliser |
| A | PHE573 | electrostatic stabiliser |
| A | GLU575 | proton acceptor |
| A | ILE576 | electrostatic stabiliser |
| A | VAL577 | electrostatic stabiliser |
| A | CYS579 | electrostatic stabiliser |
| A | LEU611 | electrostatic stabiliser |
| A | ILE642 | electrostatic stabiliser |
| A | TYR645 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| B | PHE568 | electrostatic stabiliser |
| B | PHE573 | electrostatic stabiliser |
| B | GLU575 | proton acceptor |
| B | ILE576 | electrostatic stabiliser |
| B | VAL577 | electrostatic stabiliser |
| B | CYS579 | electrostatic stabiliser |
| B | LEU611 | electrostatic stabiliser |
| B | ILE642 | electrostatic stabiliser |
| B | TYR645 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| C | PHE568 | electrostatic stabiliser |
| C | PHE573 | electrostatic stabiliser |
| C | GLU575 | proton acceptor |
| C | ILE576 | electrostatic stabiliser |
| C | VAL577 | electrostatic stabiliser |
| C | CYS579 | electrostatic stabiliser |
| C | LEU611 | electrostatic stabiliser |
| C | ILE642 | electrostatic stabiliser |
| C | TYR645 | electrostatic stabiliser |
