8E6O
Crystal structure of human GCN5 histone acetyltransferase domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004402 | molecular_function | histone acetyltransferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0004402 | molecular_function | histone acetyltransferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0004402 | molecular_function | histone acetyltransferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:31527837 |
| Chain | Residue | Details |
| A | GLU575 | |
| B | GLU575 | |
| C | GLU575 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:29211711, ECO:0007744|PDB:5TRL |
| Chain | Residue | Details |
| A | CYS579 | |
| A | GLN586 | |
| A | TYR617 | |
| B | CYS579 | |
| B | GLN586 | |
| B | TYR617 | |
| C | CYS579 | |
| C | GLN586 | |
| C | TYR617 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:23142079 |
| Chain | Residue | Details |
| A | LYS549 | |
| B | LYS549 | |
| C | LYS549 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| A | PHE568 | electrostatic stabiliser |
| A | PHE573 | electrostatic stabiliser |
| A | GLU575 | proton acceptor |
| A | ILE576 | electrostatic stabiliser |
| A | VAL577 | electrostatic stabiliser |
| A | CYS579 | electrostatic stabiliser |
| A | LEU611 | electrostatic stabiliser |
| A | ILE642 | electrostatic stabiliser |
| A | TYR645 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| B | PHE568 | electrostatic stabiliser |
| B | PHE573 | electrostatic stabiliser |
| B | GLU575 | proton acceptor |
| B | ILE576 | electrostatic stabiliser |
| B | VAL577 | electrostatic stabiliser |
| B | CYS579 | electrostatic stabiliser |
| B | LEU611 | electrostatic stabiliser |
| B | ILE642 | electrostatic stabiliser |
| B | TYR645 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 9 |
| Details | M-CSA 524 |
| Chain | Residue | Details |
| C | PHE568 | electrostatic stabiliser |
| C | PHE573 | electrostatic stabiliser |
| C | GLU575 | proton acceptor |
| C | ILE576 | electrostatic stabiliser |
| C | VAL577 | electrostatic stabiliser |
| C | CYS579 | electrostatic stabiliser |
| C | LEU611 | electrostatic stabiliser |
| C | ILE642 | electrostatic stabiliser |
| C | TYR645 | electrostatic stabiliser |
