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8E28

Human Dis3L2 in complex with hairpin A-GCU14

Functional Information from GO Data
ChainGOidnamespacecontents
A0000175molecular_function3'-5'-RNA exonuclease activity
A0000278biological_processmitotic cell cycle
A0000287molecular_functionmagnesium ion binding
A0000932cellular_componentP-body
A0000956biological_processnuclear-transcribed mRNA catabolic process
A0003723molecular_functionRNA binding
A0004518molecular_functionnuclease activity
A0004527molecular_functionexonuclease activity
A0004540molecular_functionRNA nuclease activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005844cellular_componentobsolete polysome
A0006402biological_processmRNA catabolic process
A0008266molecular_functionpoly(U) RNA binding
A0008285biological_processnegative regulation of cell population proliferation
A0010587biological_processmiRNA catabolic process
A0016787molecular_functionhydrolase activity
A0019827biological_processstem cell population maintenance
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0051306biological_processmitotic sister chromatid separation
A1990074biological_processpolyuridylation-dependent mRNA catabolic process
Functional Information from PROSITE/UniProt
site_idPS01175
Number of Residues25
DetailsRIBONUCLEASE_II Ribonuclease II family signature. HYALnvpl.YThFTSPIRRFaDvlvH
ChainResidueDetails
AHIS688-HIS712

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_03045","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsSite: {"description":"Important for catalytic activity","evidences":[{"source":"HAMAP-Rule","id":"MF_03045","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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