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8E27

RNA-free Human Dis3L2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000175molecular_function3'-5'-RNA exonuclease activity
A0000278biological_processmitotic cell cycle
A0000287molecular_functionmagnesium ion binding
A0000932cellular_componentP-body
A0000956biological_processnuclear-transcribed mRNA catabolic process
A0003723molecular_functionRNA binding
A0004527molecular_functionexonuclease activity
A0004540molecular_functionRNA nuclease activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005844cellular_componentobsolete polysome
A0006402biological_processmRNA catabolic process
A0008266molecular_functionpoly(U) RNA binding
A0008285biological_processnegative regulation of cell population proliferation
A0008408molecular_function3'-5' exonuclease activity
A0010587biological_processmiRNA catabolic process
A0016896molecular_functionRNA exonuclease activity, producing 5'-phosphomonoesters
A0019827biological_processstem cell population maintenance
A0046872molecular_functionmetal ion binding
A0051301biological_processcell division
A0051306biological_processmitotic sister chromatid separation
A1990074biological_processpolyuridylation-dependent mRNA catabolic process
Functional Information from PROSITE/UniProt
site_idPS01175
Number of Residues25
DetailsRIBONUCLEASE_II Ribonuclease II family signature. HYALnvpl.YThFTSPIRRFaDvlvH
ChainResidueDetails
AHIS688-HIS712

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03045
ChainResidueDetails
AASP383
AASP392

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_03045
ChainResidueDetails
AASN391

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER31

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER173

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS252

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PDB entries from 2024-07-24

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