8E1M

Cryo-EM structure of the endogenous core TIM23 complex from S. cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
A	0005758	cellular_component	mitochondrial intermembrane space
A	0006886	biological_process	intracellular protein transport
A	0008320	molecular_function	protein transmembrane transporter activity
A	0015031	biological_process	protein transport
A	0030150	biological_process	protein import into mitochondrial matrix
A	0045039	biological_process	protein insertion into mitochondrial inner membrane
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
B	0005758	cellular_component	mitochondrial intermembrane space
B	0006886	biological_process	intracellular protein transport
B	0008320	molecular_function	protein transmembrane transporter activity
B	0015031	biological_process	protein transport
B	0022857	molecular_function	transmembrane transporter activity
B	0030150	biological_process	protein import into mitochondrial matrix
B	0030943	molecular_function	mitochondrion targeting sequence binding
B	0045039	biological_process	protein insertion into mitochondrial inner membrane
C	0000166	molecular_function	nucleotide binding
C	0001405	cellular_component	PAM complex, Tim23 associated import motor
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005744	cellular_component	TIM23 mitochondrial import inner membrane translocase complex
C	0006886	biological_process	intracellular protein transport
C	0015031	biological_process	protein transport
C	0030150	biological_process	protein import into mitochondrial matrix
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031314	cellular_component	extrinsic component of mitochondrial inner membrane
C	0051087	molecular_function	protein-folding chaperone binding

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	13
Details	LIPOCALIN Lipocalin signature. GGAl.AVRGGWRHT

Chain	Residue	Details
A	GLY99-THR111

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR216-HIS222

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	59
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	11
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27265872","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	74
Details	Transmembrane: {"description":"Helical; Note=Inner membrane","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---