Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8E05

Structure of dimeric LRRK1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0009967	biological_process	positive regulation of signal transduction
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
A	0106310	molecular_function	protein serine kinase activity
B	0000166	molecular_function	nucleotide binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006468	biological_process	protein phosphorylation
B	0009967	biological_process	positive regulation of signal transduction
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
B	0106310	molecular_function	protein serine kinase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Repeat: {"description":"ANK 1","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	60
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	58
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	60
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	58
Details	Repeat: {"description":"ANK 5","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	42
Details	Repeat: {"description":"LRR 1","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	42
Details	Repeat: {"description":"LRR 2","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	42
Details	Repeat: {"description":"LRR 3","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	42
Details	Repeat: {"description":"LRR 4","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	42
Details	Repeat: {"description":"LRR 5","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	42
Details	Repeat: {"description":"LRR 6","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	40
Details	Repeat: {"description":"LRR 7","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	42
Details	Repeat: {"description":"LRR 8","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	42
Details	Repeat: {"description":"LRR 9","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	42
Details	Repeat: {"description":"LRR 11","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	44
Details	Repeat: {"description":"LRR 12","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	42
Details	Repeat: {"description":"LRR 13","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	388
Details	Domain: {"description":"Roc","evidences":[{"source":"PROSITE-ProRule","id":"PRU00758","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	384
Details	Domain: {"description":"COR","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	80
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	80
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	90
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	72
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	96
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	72
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E04","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"PubMed","id":"36040231","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"36040231","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)