Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8E04

Structure of monomeric LRRK1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006468	biological_process	protein phosphorylation
A	0009967	biological_process	positive regulation of signal transduction
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
A	0106310	molecular_function	protein serine kinase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Repeat: {"description":"LRR 5","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	21
Details	Repeat: {"description":"LRR 6","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	20
Details	Repeat: {"description":"LRR 7","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	21
Details	Repeat: {"description":"LRR 8","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	21
Details	Repeat: {"description":"LRR 9","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	21
Details	Repeat: {"description":"LRR 11","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	22
Details	Repeat: {"description":"LRR 12","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	21
Details	Repeat: {"description":"LRR 13","evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	40
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	36
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	48
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	36
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8E06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E04","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37558661","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37857821","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8E05","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8FAC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"36040231","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"source":"PubMed","id":"36040231","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)