8DWT

SPOP W22R Form 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000209	biological_process	protein polyubiquitination
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0016567	biological_process	protein ubiquitination
A	0016607	cellular_component	nuclear speck
A	0030162	biological_process	regulation of proteolysis
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0042802	molecular_function	identical protein binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0140678	molecular_function	molecular function inhibitor activity
B	0000209	biological_process	protein polyubiquitination
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0016567	biological_process	protein ubiquitination
B	0016607	cellular_component	nuclear speck
B	0030162	biological_process	regulation of proteolysis
B	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0042802	molecular_function	identical protein binding
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0140678	molecular_function	molecular function inhibitor activity
C	0000209	biological_process	protein polyubiquitination
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0016567	biological_process	protein ubiquitination
C	0016607	cellular_component	nuclear speck
C	0030162	biological_process	regulation of proteolysis
C	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0042802	molecular_function	identical protein binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0140678	molecular_function	molecular function inhibitor activity
D	0000209	biological_process	protein polyubiquitination
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0016567	biological_process	protein ubiquitination
D	0016607	cellular_component	nuclear speck
D	0030162	biological_process	regulation of proteolysis
D	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0042802	molecular_function	identical protein binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0140678	molecular_function	molecular function inhibitor activity
E	0000209	biological_process	protein polyubiquitination
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0016567	biological_process	protein ubiquitination
E	0016607	cellular_component	nuclear speck
E	0030162	biological_process	regulation of proteolysis
E	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0042802	molecular_function	identical protein binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0140678	molecular_function	molecular function inhibitor activity
F	0000209	biological_process	protein polyubiquitination
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0016567	biological_process	protein ubiquitination
F	0016607	cellular_component	nuclear speck
F	0030162	biological_process	regulation of proteolysis
F	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0042802	molecular_function	identical protein binding
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0140678	molecular_function	molecular function inhibitor activity
G	0000209	biological_process	protein polyubiquitination
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0016567	biological_process	protein ubiquitination
G	0016607	cellular_component	nuclear speck
G	0030162	biological_process	regulation of proteolysis
G	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0042802	molecular_function	identical protein binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0140678	molecular_function	molecular function inhibitor activity
H	0000209	biological_process	protein polyubiquitination
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0016567	biological_process	protein ubiquitination
H	0016607	cellular_component	nuclear speck
H	0030162	biological_process	regulation of proteolysis
H	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0042802	molecular_function	identical protein binding
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0140678	molecular_function	molecular function inhibitor activity
I	0000209	biological_process	protein polyubiquitination
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0016567	biological_process	protein ubiquitination
I	0016607	cellular_component	nuclear speck
I	0030162	biological_process	regulation of proteolysis
I	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0042802	molecular_function	identical protein binding
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0140678	molecular_function	molecular function inhibitor activity
J	0000209	biological_process	protein polyubiquitination
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0016567	biological_process	protein ubiquitination
J	0016607	cellular_component	nuclear speck
J	0030162	biological_process	regulation of proteolysis
J	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0042802	molecular_function	identical protein binding
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0140678	molecular_function	molecular function inhibitor activity
K	0000209	biological_process	protein polyubiquitination
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005654	cellular_component	nucleoplasm
K	0005737	cellular_component	cytoplasm
K	0016567	biological_process	protein ubiquitination
K	0016607	cellular_component	nuclear speck
K	0030162	biological_process	regulation of proteolysis
K	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
K	0031625	molecular_function	ubiquitin protein ligase binding
K	0042802	molecular_function	identical protein binding
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0140678	molecular_function	molecular function inhibitor activity
L	0000209	biological_process	protein polyubiquitination
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005654	cellular_component	nucleoplasm
L	0005737	cellular_component	cytoplasm
L	0016567	biological_process	protein ubiquitination
L	0016607	cellular_component	nuclear speck
L	0030162	biological_process	regulation of proteolysis
L	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
L	0031625	molecular_function	ubiquitin protein ligase binding
L	0042802	molecular_function	identical protein binding
L	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
L	0140678	molecular_function	molecular function inhibitor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1560
Details	Domain: {"description":"MATH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00129","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1488
Details	Domain: {"description":"BTB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00037","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1440
Details	Region: {"description":"Required for nuclear localization"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	120
Details	Region: {"description":"Important for binding substrate proteins"}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1068
Details	Region: {"description":"Important for homodimerization"}

Chain

Residue

Details

---