Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8DWR

Crystal structure of the L333V variant of catalase-peroxidase from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004096	molecular_function	catalase activity
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006979	biological_process	response to oxidative stress
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016677	molecular_function	oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
A	0020037	molecular_function	heme binding
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0045739	biological_process	positive regulation of DNA repair
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0070402	molecular_function	NADPH binding
A	0070404	molecular_function	NADH binding
A	0098869	biological_process	cellular oxidant detoxification
B	0004096	molecular_function	catalase activity
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006979	biological_process	response to oxidative stress
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016677	molecular_function	oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
B	0020037	molecular_function	heme binding
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0045739	biological_process	positive regulation of DNA repair
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0070402	molecular_function	NADPH binding
B	0070404	molecular_function	NADH binding
B	0098869	biological_process	cellular oxidant detoxification
C	0004096	molecular_function	catalase activity
C	0004601	molecular_function	peroxidase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006979	biological_process	response to oxidative stress
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0016677	molecular_function	oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
C	0020037	molecular_function	heme binding
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0045739	biological_process	positive regulation of DNA repair
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0070402	molecular_function	NADPH binding
C	0070404	molecular_function	NADH binding
C	0098869	biological_process	cellular oxidant detoxification
D	0004096	molecular_function	catalase activity
D	0004601	molecular_function	peroxidase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006979	biological_process	response to oxidative stress
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0016677	molecular_function	oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
D	0020037	molecular_function	heme binding
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0045739	biological_process	positive regulation of DNA repair
D	0046677	biological_process	response to antibiotic
D	0046872	molecular_function	metal ion binding
D	0070301	biological_process	cellular response to hydrogen peroxide
D	0070402	molecular_function	NADPH binding
D	0070404	molecular_function	NADH binding
D	0098869	biological_process	cellular oxidant detoxification

Functional Information from PROSITE/UniProt

site_id	PS00435
Number of Residues	11
Details	PEROXIDASE_1 Peroxidases proximal heme-ligand signature. TAALIVGGHTF

Chain	Residue	Details
A	THR262-PHE272

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255\|HAMAP-Rule:MF_01961

Chain	Residue	Details
A	HIS108
B	HIS108
C	HIS108
D	HIS108

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Tryptophan radical intermediate => ECO:0000269\|PubMed:18052167

Chain	Residue	Details
A	TRP321
B	TRP321
C	TRP321
D	TRP321

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:15231843, ECO:0000269\|PubMed:16566587, ECO:0000269\|PubMed:24185282, ECO:0007744\|PDB:1SJ2, ECO:0007744\|PDB:2CCA, ECO:0007744\|PDB:2CCD, ECO:0007744\|PDB:4C51

Chain	Residue	Details
A	HIS270
B	HIS270
C	HIS270
D	HIS270

site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Transition state stabilizer => ECO:0000255\|HAMAP-Rule:MF_01961

Chain	Residue	Details
A	ARG104
B	ARG104
C	ARG104
D	ARG104

site_id	SWS_FT_FI5
Number of Residues	4
Details	CROSSLNK: Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-255); alternate => ECO:0000255\|HAMAP-Rule:MF_01961, ECO:0000269\|PubMed:15231843

Chain	Residue	Details
A	TOX107
B	TOX107
C	TOX107
D	TOX107

site_id	SWS_FT_FI6
Number of Residues	8
Details	CROSSLNK: Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-107); alternate => ECO:0000255\|HAMAP-Rule:MF_01961, ECO:0000269\|PubMed:15231843

Chain	Residue	Details
A	TYR229
A	MET255
B	TYR229
B	MET255
C	TYR229
C	MET255
D	TYR229
D	MET255

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)