8DSA

LRRC8A:C in MSP1E3D1 nanodisc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0009055	molecular_function	electron transfer activity
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding
B	0005506	molecular_function	iron ion binding
B	0009055	molecular_function	electron transfer activity
B	0020037	molecular_function	heme binding
B	0022900	biological_process	electron transport chain
B	0042597	cellular_component	periplasmic space
B	0046872	molecular_function	metal ion binding
C	0005506	molecular_function	iron ion binding
C	0009055	molecular_function	electron transfer activity
C	0020037	molecular_function	heme binding
C	0022900	biological_process	electron transport chain
C	0042597	cellular_component	periplasmic space
C	0046872	molecular_function	metal ion binding
D	0005506	molecular_function	iron ion binding
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
D	0022900	biological_process	electron transport chain
D	0042597	cellular_component	periplasmic space
D	0046872	molecular_function	metal ion binding
E	0005506	molecular_function	iron ion binding
E	0009055	molecular_function	electron transfer activity
E	0020037	molecular_function	heme binding
E	0022900	biological_process	electron transport chain
E	0042597	cellular_component	periplasmic space
E	0046872	molecular_function	metal ion binding
F	0005225	molecular_function	volume-sensitive anion channel activity
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0015734	biological_process	taurine transmembrane transport
F	0015810	biological_process	aspartate transmembrane transport
F	0016020	cellular_component	membrane
F	0034214	biological_process	protein hexamerization
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0034702	cellular_component	monoatomic ion channel complex
F	0045444	biological_process	fat cell differentiation
F	0055085	biological_process	transmembrane transport
F	0071470	biological_process	cellular response to osmotic stress
F	0098656	biological_process	monoatomic anion transmembrane transport
F	0140361	biological_process	cyclic-GMP-AMP transmembrane import across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	601
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK

Chain	Residue	Details
F	MET1-PRO22
D	MET1-PRO22
D	TRP143-TYR264
D	TRP342-ALA810
E	MET1-PRO22
E	TRP143-TYR264
E	TRP342-ALA810
F	TRP145-TYR262
F	TRP340-ASP803
B	MET1-PRO22
B	TRP143-TYR264
B	TRP342-ALA810
C	MET1-PRO22
C	TRP143-TYR264
C	TRP342-ALA810

---

site_id	SWS_FT_FI2
Number of Residues	25
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK

Chain	Residue	Details
F	TRP23-MET48
B	TRP23-VAL47
C	TRP23-VAL47
D	TRP23-VAL47
E	TRP23-VAL47

---

site_id	SWS_FT_FI3
Number of Residues	104
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK

Chain	Residue	Details
F	GLN49-ALA124
F	SER285-HIS314
C	TYR124-PHE142
D	TYR124-PHE142
E	TYR124-PHE142

---

site_id	SWS_FT_FI4
Number of Residues	19
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK

Chain	Residue	Details
F	LYS125-PHE144
B	MET265-VAL286
C	MET265-VAL286
D	MET265-VAL286
E	MET265-VAL286

---

site_id	SWS_FT_FI5
Number of Residues	21
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK

Chain	Residue	Details
F	VAL263-VAL284
B	HIS287-THR316
C	HIS287-THR316
D	HIS287-THR316
E	HIS287-THR316

---

site_id	SWS_FT_FI6
Number of Residues	24
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK

Chain	Residue	Details
F	LEU315-TYR339
B	LEU317-TRP341
C	LEU317-TRP341
D	LEU317-TRP341
E	LEU317-TRP341

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8TDW0

Chain	Residue	Details
F	SER212
B	ARG103
C	ARG103
D	ARG103
E	ARG103

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q498T9

Chain	Residue	Details
F	SER215
B	MET1
C	MET1
D	MET1
E	MET1

---

site_id	SWS_FT_FI9
Number of Residues	5
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	THR200
B	THR200
C	THR200
D	THR200
E	THR200

---

site_id	SWS_FT_FI10
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	SER202
B	SER202
C	SER202
D	SER202
E	SER202

---

site_id	SWS_FT_FI11
Number of Residues	5
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8IWT6

Chain	Residue	Details
A	THR215
B	THR215
C	THR215
D	THR215
E	THR215

---

site_id	SWS_FT_FI12
Number of Residues	5
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8IWT6

Chain	Residue	Details
A	SER217
B	SER217
C	SER217
D	SER217
E	SER217

---

site_id	SWS_FT_FI13
Number of Residues	5
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN66
B	ASN66
C	ASN66
D	ASN66
E	ASN66

---

site_id	SWS_FT_FI14
Number of Residues	10
Details	BINDING: axial binding residue

Chain	Residue	Details
A	TRP68
E	ILE72
A	ILE72
B	TRP68
B	ILE72
C	TRP68
C	ILE72
D	TRP68
D	ILE72
E	TRP68

---