Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8DRK

LRRC8A:C conformation 1 (round) top focus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0009055	molecular_function	electron transfer activity
A	0020037	molecular_function	heme binding
A	0022900	biological_process	electron transport chain
A	0042597	cellular_component	periplasmic space
A	0046872	molecular_function	metal ion binding
B	0005506	molecular_function	iron ion binding
B	0009055	molecular_function	electron transfer activity
B	0020037	molecular_function	heme binding
B	0022900	biological_process	electron transport chain
B	0042597	cellular_component	periplasmic space
B	0046872	molecular_function	metal ion binding
C	0005506	molecular_function	iron ion binding
C	0009055	molecular_function	electron transfer activity
C	0020037	molecular_function	heme binding
C	0022900	biological_process	electron transport chain
C	0042597	cellular_component	periplasmic space
C	0046872	molecular_function	metal ion binding
D	0005506	molecular_function	iron ion binding
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
D	0022900	biological_process	electron transport chain
D	0042597	cellular_component	periplasmic space
D	0046872	molecular_function	metal ion binding
E	0005506	molecular_function	iron ion binding
E	0009055	molecular_function	electron transfer activity
E	0020037	molecular_function	heme binding
E	0022900	biological_process	electron transport chain
E	0042597	cellular_component	periplasmic space
E	0046872	molecular_function	metal ion binding
F	0005225	molecular_function	volume-sensitive anion channel activity
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0015734	biological_process	taurine transmembrane transport
F	0015810	biological_process	aspartate transmembrane transport
F	0016020	cellular_component	membrane
F	0034214	biological_process	protein hexamerization
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0034702	cellular_component	monoatomic ion channel complex
F	0045444	biological_process	fat cell differentiation
F	0055085	biological_process	transmembrane transport
F	0071470	biological_process	cellular response to osmotic stress
F	0098656	biological_process	monoatomic anion transmembrane transport
F	0140361	biological_process	cyclic-GMP-AMP transmembrane import across plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	120
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	90
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	105
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	145
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	120
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"30775971","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6NZZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6O00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	5
Details	Site: {"description":"Required for anion selectivity","evidences":[{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000303"},{"source":"PDB","id":"8B41","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8B42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	29
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"36522427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36928458","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8B40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)