8DPS

The structure of the interleukin 11 signalling complex, truncated gp130

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001960	biological_process	negative regulation of cytokine-mediated signaling pathway
B	0005125	molecular_function	cytokine activity
B	0005142	molecular_function	interleukin-11 receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0008083	molecular_function	growth factor activity
B	0008284	biological_process	positive regulation of cell population proliferation
B	0030183	biological_process	B cell differentiation
B	0030219	biological_process	megakaryocyte differentiation
B	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
B	0038154	biological_process	interleukin-11-mediated signaling pathway
B	0043410	biological_process	positive regulation of MAPK cascade
B	0045444	biological_process	fat cell differentiation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046888	biological_process	negative regulation of hormone secretion
B	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
B	0060302	biological_process	negative regulation of cytokine activity
B	1903659	biological_process	regulation of complement-dependent cytotoxicity
B	2000352	biological_process	negative regulation of endothelial cell apoptotic process
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane
E	0001960	biological_process	negative regulation of cytokine-mediated signaling pathway
E	0005125	molecular_function	cytokine activity
E	0005142	molecular_function	interleukin-11 receptor binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0008083	molecular_function	growth factor activity
E	0008284	biological_process	positive regulation of cell population proliferation
E	0030183	biological_process	B cell differentiation
E	0030219	biological_process	megakaryocyte differentiation
E	0033138	biological_process	positive regulation of peptidyl-serine phosphorylation
E	0038154	biological_process	interleukin-11-mediated signaling pathway
E	0043410	biological_process	positive regulation of MAPK cascade
E	0045444	biological_process	fat cell differentiation
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0046888	biological_process	negative regulation of hormone secretion
E	0050731	biological_process	positive regulation of peptidyl-tyrosine phosphorylation
E	0060302	biological_process	negative regulation of cytokine activity
E	1903659	biological_process	regulation of complement-dependent cytotoxicity
E	2000352	biological_process	negative regulation of endothelial cell apoptotic process
F	0004896	molecular_function	cytokine receptor activity
F	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS01354
Number of Residues	43
Details	HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. LrPDPPqgLrvesvpgyprrLrasWtyPaSWpsqph.FlLkFrL

Chain	Residue	Details
C	LEU194-LEU236

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	188
Details	Domain: {"description":"Ig-like C2-type"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	182
Details	Domain: {"description":"Fibronectin type-III 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	16
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11098061","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20489211","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	16
Details	Region: {"description":"Important for interaction with IL11RA and for the stimulation of cell proliferation","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	2
Details	Site: {"description":"Important for interaction with IL6ST and for the stimulation of cell proliferation","evidences":[{"source":"UniProtKB","id":"P47873","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	194
Details	Domain: {"description":"Fibronectin type-III 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00316","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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