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8DNU

Human Brain Glutamine Synthetase

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0003824molecular_functioncatalytic activity
A0004356molecular_functionglutamine synthetase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006538biological_processglutamate catabolic process
A0006542biological_processglutamine biosynthetic process
A0008283biological_processcell population proliferation
A0009267biological_processcellular response to starvation
A0009749biological_processresponse to glucose
A0010594biological_processregulation of endothelial cell migration
A0016740molecular_functiontransferase activity
A0016874molecular_functionligase activity
A0018345biological_processprotein palmitoylation
A0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
A0042254biological_processribosome biogenesis
A0042802molecular_functionidentical protein binding
A0044297cellular_componentcell body
A0046872molecular_functionmetal ion binding
A0070062cellular_componentextracellular exosome
A0097386cellular_componentglial cell projection
A1903670biological_processregulation of sprouting angiogenesis
A1904749biological_processregulation of protein localization to nucleolus
B0001525biological_processangiogenesis
B0003824molecular_functioncatalytic activity
B0004356molecular_functionglutamine synthetase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006538biological_processglutamate catabolic process
B0006542biological_processglutamine biosynthetic process
B0008283biological_processcell population proliferation
B0009267biological_processcellular response to starvation
B0009749biological_processresponse to glucose
B0010594biological_processregulation of endothelial cell migration
B0016740molecular_functiontransferase activity
B0016874molecular_functionligase activity
B0018345biological_processprotein palmitoylation
B0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
B0042254biological_processribosome biogenesis
B0042802molecular_functionidentical protein binding
B0044297cellular_componentcell body
B0046872molecular_functionmetal ion binding
B0070062cellular_componentextracellular exosome
B0097386cellular_componentglial cell projection
B1903670biological_processregulation of sprouting angiogenesis
B1904749biological_processregulation of protein localization to nucleolus
C0001525biological_processangiogenesis
C0003824molecular_functioncatalytic activity
C0004356molecular_functionglutamine synthetase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006538biological_processglutamate catabolic process
C0006542biological_processglutamine biosynthetic process
C0008283biological_processcell population proliferation
C0009267biological_processcellular response to starvation
C0009749biological_processresponse to glucose
C0010594biological_processregulation of endothelial cell migration
C0016740molecular_functiontransferase activity
C0016874molecular_functionligase activity
C0018345biological_processprotein palmitoylation
C0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
C0042254biological_processribosome biogenesis
C0042802molecular_functionidentical protein binding
C0044297cellular_componentcell body
C0046872molecular_functionmetal ion binding
C0070062cellular_componentextracellular exosome
C0097386cellular_componentglial cell projection
C1903670biological_processregulation of sprouting angiogenesis
C1904749biological_processregulation of protein localization to nucleolus
D0001525biological_processangiogenesis
D0003824molecular_functioncatalytic activity
D0004356molecular_functionglutamine synthetase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005783cellular_componentendoplasmic reticulum
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006538biological_processglutamate catabolic process
D0006542biological_processglutamine biosynthetic process
D0008283biological_processcell population proliferation
D0009267biological_processcellular response to starvation
D0009749biological_processresponse to glucose
D0010594biological_processregulation of endothelial cell migration
D0016740molecular_functiontransferase activity
D0016874molecular_functionligase activity
D0018345biological_processprotein palmitoylation
D0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
D0042254biological_processribosome biogenesis
D0042802molecular_functionidentical protein binding
D0044297cellular_componentcell body
D0046872molecular_functionmetal ion binding
D0070062cellular_componentextracellular exosome
D0097386cellular_componentglial cell projection
D1903670biological_processregulation of sprouting angiogenesis
D1904749biological_processregulation of protein localization to nucleolus
E0001525biological_processangiogenesis
E0003824molecular_functioncatalytic activity
E0004356molecular_functionglutamine synthetase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005783cellular_componentendoplasmic reticulum
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006538biological_processglutamate catabolic process
E0006542biological_processglutamine biosynthetic process
E0008283biological_processcell population proliferation
E0009267biological_processcellular response to starvation
E0009749biological_processresponse to glucose
E0010594biological_processregulation of endothelial cell migration
E0016740molecular_functiontransferase activity
E0016874molecular_functionligase activity
E0018345biological_processprotein palmitoylation
E0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
E0042254biological_processribosome biogenesis
E0042802molecular_functionidentical protein binding
E0044297cellular_componentcell body
E0046872molecular_functionmetal ion binding
E0070062cellular_componentextracellular exosome
E0097386cellular_componentglial cell projection
E1903670biological_processregulation of sprouting angiogenesis
E1904749biological_processregulation of protein localization to nucleolus
F0001525biological_processangiogenesis
F0003824molecular_functioncatalytic activity
F0004356molecular_functionglutamine synthetase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005783cellular_componentendoplasmic reticulum
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006538biological_processglutamate catabolic process
F0006542biological_processglutamine biosynthetic process
F0008283biological_processcell population proliferation
F0009267biological_processcellular response to starvation
F0009749biological_processresponse to glucose
F0010594biological_processregulation of endothelial cell migration
F0016740molecular_functiontransferase activity
F0016874molecular_functionligase activity
F0018345biological_processprotein palmitoylation
F0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
F0042254biological_processribosome biogenesis
F0042802molecular_functionidentical protein binding
F0044297cellular_componentcell body
F0046872molecular_functionmetal ion binding
F0070062cellular_componentextracellular exosome
F0097386cellular_componentglial cell projection
F1903670biological_processregulation of sprouting angiogenesis
F1904749biological_processregulation of protein localization to nucleolus
G0001525biological_processangiogenesis
G0003824molecular_functioncatalytic activity
G0004356molecular_functionglutamine synthetase activity
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005783cellular_componentendoplasmic reticulum
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0006538biological_processglutamate catabolic process
G0006542biological_processglutamine biosynthetic process
G0008283biological_processcell population proliferation
G0009267biological_processcellular response to starvation
G0009749biological_processresponse to glucose
G0010594biological_processregulation of endothelial cell migration
G0016740molecular_functiontransferase activity
G0016874molecular_functionligase activity
G0018345biological_processprotein palmitoylation
G0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
G0042254biological_processribosome biogenesis
G0042802molecular_functionidentical protein binding
G0044297cellular_componentcell body
G0046872molecular_functionmetal ion binding
G0070062cellular_componentextracellular exosome
G0097386cellular_componentglial cell projection
G1903670biological_processregulation of sprouting angiogenesis
G1904749biological_processregulation of protein localization to nucleolus
H0001525biological_processangiogenesis
H0003824molecular_functioncatalytic activity
H0004356molecular_functionglutamine synthetase activity
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005783cellular_componentendoplasmic reticulum
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0006538biological_processglutamate catabolic process
H0006542biological_processglutamine biosynthetic process
H0008283biological_processcell population proliferation
H0009267biological_processcellular response to starvation
H0009749biological_processresponse to glucose
H0010594biological_processregulation of endothelial cell migration
H0016740molecular_functiontransferase activity
H0016874molecular_functionligase activity
H0018345biological_processprotein palmitoylation
H0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
H0042254biological_processribosome biogenesis
H0042802molecular_functionidentical protein binding
H0044297cellular_componentcell body
H0046872molecular_functionmetal ion binding
H0070062cellular_componentextracellular exosome
H0097386cellular_componentglial cell projection
H1903670biological_processregulation of sprouting angiogenesis
H1904749biological_processregulation of protein localization to nucleolus
I0001525biological_processangiogenesis
I0003824molecular_functioncatalytic activity
I0004356molecular_functionglutamine synthetase activity
I0005515molecular_functionprotein binding
I0005524molecular_functionATP binding
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005783cellular_componentendoplasmic reticulum
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0006538biological_processglutamate catabolic process
I0006542biological_processglutamine biosynthetic process
I0008283biological_processcell population proliferation
I0009267biological_processcellular response to starvation
I0009749biological_processresponse to glucose
I0010594biological_processregulation of endothelial cell migration
I0016740molecular_functiontransferase activity
I0016874molecular_functionligase activity
I0018345biological_processprotein palmitoylation
I0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
I0042254biological_processribosome biogenesis
I0042802molecular_functionidentical protein binding
I0044297cellular_componentcell body
I0046872molecular_functionmetal ion binding
I0070062cellular_componentextracellular exosome
I0097386cellular_componentglial cell projection
I1903670biological_processregulation of sprouting angiogenesis
I1904749biological_processregulation of protein localization to nucleolus
J0001525biological_processangiogenesis
J0003824molecular_functioncatalytic activity
J0004356molecular_functionglutamine synthetase activity
J0005515molecular_functionprotein binding
J0005524molecular_functionATP binding
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005783cellular_componentendoplasmic reticulum
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0006538biological_processglutamate catabolic process
J0006542biological_processglutamine biosynthetic process
J0008283biological_processcell population proliferation
J0009267biological_processcellular response to starvation
J0009749biological_processresponse to glucose
J0010594biological_processregulation of endothelial cell migration
J0016740molecular_functiontransferase activity
J0016874molecular_functionligase activity
J0018345biological_processprotein palmitoylation
J0019706molecular_functionprotein-cysteine S-palmitoyltransferase activity
J0042254biological_processribosome biogenesis
J0042802molecular_functionidentical protein binding
J0044297cellular_componentcell body
J0046872molecular_functionmetal ion binding
J0070062cellular_componentextracellular exosome
J0097386cellular_componentglial cell projection
J1903670biological_processregulation of sprouting angiogenesis
J1904749biological_processregulation of protein localization to nucleolus
Functional Information from PROSITE/UniProt
site_idPS00180
Number of Residues18
DetailsGLNA_1 Glutamine synthetase signature 1. FDGSStlqsegs.NSDmyL
ChainResidueDetails
APHE62-LEU79

site_idPS00181
Number of Residues17
DetailsGLNA_ATP Glutamine synthetase putative ATP-binding region signature. KPIpgnw.NGAGcHtnfS
ChainResidueDetails
ALYS241-SER257

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues60
DetailsBINDING: BINDING => ECO:0007744|PDB:2QC8
ChainResidueDetails
AGLU134
BGLU203
BHIS253
BGLU338
CGLU134
CGLU136
CGLU196
CGLU203
CHIS253
CGLU338
DGLU134
AGLU136
DGLU136
DGLU196
DGLU203
DHIS253
DGLU338
EGLU134
EGLU136
EGLU196
EGLU203
EHIS253
AGLU196
EGLU338
FGLU134
FGLU136
FGLU196
FGLU203
FHIS253
FGLU338
GGLU134
GGLU136
GGLU196
AGLU203
GGLU203
GHIS253
GGLU338
HGLU134
HGLU136
HGLU196
HGLU203
HHIS253
HGLU338
IGLU134
AHIS253
IGLU136
IGLU196
IGLU203
IHIS253
IGLU338
JGLU134
JGLU136
JGLU196
JGLU203
JHIS253
AGLU338
JGLU338
BGLU134
BGLU136
BGLU196

site_idSWS_FT_FI2
Number of Residues30
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P9WN39
ChainResidueDetails
AASN246
DASN246
DARG319
DARG340
EASN246
EARG319
EARG340
FASN246
FARG319
FARG340
GASN246
AARG319
GARG319
GARG340
HASN246
HARG319
HARG340
IASN246
IARG319
IARG340
JASN246
JARG319
AARG340
JARG340
BASN246
BARG319
BARG340
CASN246
CARG319
CARG340

site_idSWS_FT_FI3
Number of Residues30
DetailsBINDING: BINDING => ECO:0007744|PDB:2OJW, ECO:0007744|PDB:2QC8
ChainResidueDetails
AASN255
DASN255
DARG324
DTYR336
EASN255
EARG324
ETYR336
FASN255
FARG324
FTYR336
GASN255
AARG324
GARG324
GTYR336
HASN255
HARG324
HTYR336
IASN255
IARG324
ITYR336
JASN255
JARG324
ATYR336
JTYR336
BASN255
BARG324
BTYR336
CASN255
CARG324
CTYR336

site_idSWS_FT_FI4
Number of Residues10
DetailsMOD_RES: N-acetylthreonine => ECO:0007744|PubMed:19413330
ChainResidueDetails
ATHR2
JTHR2
BTHR2
CTHR2
DTHR2
ETHR2
FTHR2
GTHR2
HTHR2
ITHR2

site_idSWS_FT_FI5
Number of Residues10
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P15105
ChainResidueDetails
ATYR104
JTYR104
BTYR104
CTYR104
DTYR104
ETYR104
FTYR104
GTYR104
HTYR104
ITYR104

site_idSWS_FT_FI6
Number of Residues10
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER343
JSER343
BSER343
CSER343
DSER343
ESER343
FSER343
GSER343
HSER343
ISER343

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PDB entries from 2024-07-24

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