8DN5
Cryo-EM structure of human Glycine Receptor alpha1-beta heteromer, glycine-bound state1(open state)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004888 | molecular_function | transmembrane signaling receptor activity |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0016020 | cellular_component | membrane |
A | 0016594 | molecular_function | glycine binding |
A | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0004888 | molecular_function | transmembrane signaling receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0016594 | molecular_function | glycine binding |
B | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
C | 0004888 | molecular_function | transmembrane signaling receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
C | 0005886 | cellular_component | plasma membrane |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0016020 | cellular_component | membrane |
C | 0016594 | molecular_function | glycine binding |
C | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
C | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0004888 | molecular_function | transmembrane signaling receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
D | 0005886 | cellular_component | plasma membrane |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0016020 | cellular_component | membrane |
D | 0016594 | molecular_function | glycine binding |
D | 0022824 | molecular_function | transmitter-gated monoatomic ion channel activity |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
E | 0003674 | molecular_function | molecular_function |
E | 0004888 | molecular_function | transmembrane signaling receptor activity |
E | 0005216 | molecular_function | monoatomic ion channel activity |
E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
E | 0005575 | cellular_component | cellular_component |
E | 0006091 | biological_process | generation of precursor metabolites and energy |
E | 0006811 | biological_process | monoatomic ion transport |
E | 0008218 | biological_process | bioluminescence |
E | 0016020 | cellular_component | membrane |
E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PROSITE/UniProt
site_id | PS00236 |
Number of Residues | 15 |
Details | NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CpLdLtlFPmDtqrC |
Chain | Residue | Details |
E | CYS161-CYS175 | |
D | CYS138-CYS152 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 924 |
Details | TOPO_DOM: Extracellular => ECO:0000305 |
Chain | Residue | Details |
D | ALA1-TYR222 | |
A | ALA1-TYR222 | |
B | ALA1-TYR222 | |
C | ALA1-TYR222 |
site_id | SWS_FT_FI2 |
Number of Residues | 84 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25730860 |
Chain | Residue | Details |
D | TYR223-ILE244 | |
A | TYR223-ILE244 | |
B | TYR223-ILE244 | |
C | TYR223-ILE244 |
site_id | SWS_FT_FI3 |
Number of Residues | 16 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25730860 |
Chain | Residue | Details |
D | ASN245-ALA249 | |
A | ASN245-ALA249 | |
B | ASN245-ALA249 | |
C | ASN245-ALA249 |
site_id | SWS_FT_FI4 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25730860 |
Chain | Residue | Details |
D | PRO250-SER270 | |
A | PRO250-SER270 | |
B | PRO250-SER270 | |
C | PRO250-SER270 |
site_id | SWS_FT_FI5 |
Number of Residues | 40 |
Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25730860 |
Chain | Residue | Details |
D | ARG271-LYS281 | |
A | ARG271-LYS281 | |
B | ARG271-LYS281 | |
C | ARG271-LYS281 |
site_id | SWS_FT_FI6 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:23994010, ECO:0000269|PubMed:25730860 |
Chain | Residue | Details |
D | ALA282-ALA302 | |
A | ALA282-ALA302 | |
B | ALA282-ALA302 | |
C | ALA282-ALA302 |
site_id | SWS_FT_FI7 |
Number of Residues | 376 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:23994010 |
Chain | Residue | Details |
E | TYR225 |
site_id | SWS_FT_FI8 |
Number of Residues | 80 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:23994010 |
Chain | Residue | Details |
E | LEU285 |
site_id | SWS_FT_FI9 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000305|PubMed:16144831 |
Chain | Residue | Details |
D | GLU192 | |
C | GLU192 | |
C | ASP194 | |
C | HIS215 | |
D | ASP194 | |
D | HIS215 | |
A | GLU192 | |
A | ASP194 | |
A | HIS215 | |
B | GLU192 | |
B | ASP194 | |
B | HIS215 |
site_id | SWS_FT_FI10 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:O93430 |
Chain | Residue | Details |
D | TYR202 | |
A | TYR202 | |
B | TYR202 | |
C | TYR202 |
site_id | SWS_FT_FI11 |
Number of Residues | 4 |
Details | SITE: Important for obstruction of the ion pore in the closed conformation => ECO:0000269|PubMed:25730860 |
Chain | Residue | Details |
D | LEU261 | |
A | LEU261 | |
B | LEU261 | |
C | LEU261 |
site_id | SWS_FT_FI12 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305 |
Chain | Residue | Details |
D | ASN38 | |
A | ASN38 | |
B | ASN38 | |
C | ASN38 |