8DMY

Cryo-EM structure of cardiac muscle alpha-actin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005884	cellular_component	actin filament
A	0007015	biological_process	actin filament organization
A	0010628	biological_process	positive regulation of gene expression
A	0015629	cellular_component	actin cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0017022	molecular_function	myosin binding
A	0030017	cellular_component	sarcomere
A	0030027	cellular_component	lamellipodium
A	0030175	cellular_component	filopodium
A	0031674	cellular_component	I band
A	0033275	biological_process	actin-myosin filament sliding
A	0044297	cellular_component	cell body
A	0045202	cellular_component	synapse
A	0060047	biological_process	heart contraction
A	0090131	biological_process	mesenchyme migration
A	0098978	cellular_component	glutamatergic synapse
B	0000166	molecular_function	nucleotide binding
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005884	cellular_component	actin filament
B	0007015	biological_process	actin filament organization
B	0010628	biological_process	positive regulation of gene expression
B	0015629	cellular_component	actin cytoskeleton
B	0016787	molecular_function	hydrolase activity
B	0017022	molecular_function	myosin binding
B	0030017	cellular_component	sarcomere
B	0030027	cellular_component	lamellipodium
B	0030175	cellular_component	filopodium
B	0031674	cellular_component	I band
B	0033275	biological_process	actin-myosin filament sliding
B	0044297	cellular_component	cell body
B	0045202	cellular_component	synapse
B	0060047	biological_process	heart contraction
B	0090131	biological_process	mesenchyme migration
B	0098978	cellular_component	glutamatergic synapse
C	0000166	molecular_function	nucleotide binding
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005884	cellular_component	actin filament
C	0007015	biological_process	actin filament organization
C	0010628	biological_process	positive regulation of gene expression
C	0015629	cellular_component	actin cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0017022	molecular_function	myosin binding
C	0030017	cellular_component	sarcomere
C	0030027	cellular_component	lamellipodium
C	0030175	cellular_component	filopodium
C	0031674	cellular_component	I band
C	0033275	biological_process	actin-myosin filament sliding
C	0044297	cellular_component	cell body
C	0045202	cellular_component	synapse
C	0060047	biological_process	heart contraction
C	0090131	biological_process	mesenchyme migration
C	0098978	cellular_component	glutamatergic synapse
D	0000166	molecular_function	nucleotide binding
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005884	cellular_component	actin filament
D	0007015	biological_process	actin filament organization
D	0010628	biological_process	positive regulation of gene expression
D	0015629	cellular_component	actin cytoskeleton
D	0016787	molecular_function	hydrolase activity
D	0017022	molecular_function	myosin binding
D	0030017	cellular_component	sarcomere
D	0030027	cellular_component	lamellipodium
D	0030175	cellular_component	filopodium
D	0031674	cellular_component	I band
D	0033275	biological_process	actin-myosin filament sliding
D	0044297	cellular_component	cell body
D	0045202	cellular_component	synapse
D	0060047	biological_process	heart contraction
D	0090131	biological_process	mesenchyme migration
D	0098978	cellular_component	glutamatergic synapse

Functional Information from PROSITE/UniProt

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

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site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68033","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P62739","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68032","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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