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8DMY

Cryo-EM structure of cardiac muscle alpha-actin

Functional Information from GO Data
ChainGOidnamespacecontents
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0005884cellular_componentactin filament
A0007015biological_processactin filament organization
A0010628biological_processpositive regulation of gene expression
A0016787molecular_functionhydrolase activity
A0017022molecular_functionmyosin binding
A0030017cellular_componentsarcomere
A0030027cellular_componentlamellipodium
A0030175cellular_componentfilopodium
A0033275biological_processactin-myosin filament sliding
A0044297cellular_componentcell body
A0060047biological_processheart contraction
A0090131biological_processmesenchyme migration
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0005884cellular_componentactin filament
B0007015biological_processactin filament organization
B0010628biological_processpositive regulation of gene expression
B0016787molecular_functionhydrolase activity
B0017022molecular_functionmyosin binding
B0030017cellular_componentsarcomere
B0030027cellular_componentlamellipodium
B0030175cellular_componentfilopodium
B0033275biological_processactin-myosin filament sliding
B0044297cellular_componentcell body
B0060047biological_processheart contraction
B0090131biological_processmesenchyme migration
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005856cellular_componentcytoskeleton
C0005884cellular_componentactin filament
C0007015biological_processactin filament organization
C0010628biological_processpositive regulation of gene expression
C0016787molecular_functionhydrolase activity
C0017022molecular_functionmyosin binding
C0030017cellular_componentsarcomere
C0030027cellular_componentlamellipodium
C0030175cellular_componentfilopodium
C0033275biological_processactin-myosin filament sliding
C0044297cellular_componentcell body
C0060047biological_processheart contraction
C0090131biological_processmesenchyme migration
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005856cellular_componentcytoskeleton
D0005884cellular_componentactin filament
D0007015biological_processactin filament organization
D0010628biological_processpositive regulation of gene expression
D0016787molecular_functionhydrolase activity
D0017022molecular_functionmyosin binding
D0030017cellular_componentsarcomere
D0030027cellular_componentlamellipodium
D0030175cellular_componentfilopodium
D0033275biological_processactin-myosin filament sliding
D0044297cellular_componentcell body
D0060047biological_processheart contraction
D0090131biological_processmesenchyme migration
Functional Information from PROSITE/UniProt
site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
ATYR53-GLY63

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WISKqEYDE
ChainResidueDetails
ATRP356-GLU364

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
ALEU104-ARG116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsMOD_RES: Methionine (R)-sulfoxide => ECO:0000250|UniProtKB:P68033
ChainResidueDetails
AMET44
AMET47
BMET44
BMET47
CMET44
CMET47
DMET44
DMET47

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Tele-methylhistidine => ECO:0000250|UniProtKB:P62739
ChainResidueDetails
AHIC73
BHIC73
CHIC73
DHIC73

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P68032
ChainResidueDetails
ALYS84
BLYS84
CLYS84
DLYS84

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PDB entries from 2024-07-24

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