8DKX
Cryo-EM structure of cystinosin N288K mutant in a cytosol-open state at pH7.5
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| B | TYR192-HIS198 | |
| A | TYR200-HIS206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 151 |
| Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:36113465 |
| Chain | Residue | Details |
| P | SER23-ILE125 | |
| P | LEU180-ASN202 | |
| P | GLY258-LEU263 | |
| P | GLY309-GLY331 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 143 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:36113465, ECO:0007744|PDB:8DKE, ECO:0007744|PDB:8DKI, ECO:0007744|PDB:8DKM, ECO:0007744|PDB:8DKW, ECO:0007744|PDB:8DKX, ECO:0007744|PDB:8DYP |
| Chain | Residue | Details |
| P | ILE126-TRP150 | |
| P | PHE160-GLY179 | |
| P | SER203-LEU225 | |
| P | TRP235-VAL257 | |
| P | GLN264-PHE289 | |
| P | ILE299-GLY308 | |
| P | ASP332-PHE354 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:36113465 |
| Chain | Residue | Details |
| P | ARG151-SER159 | |
| P | TYR226-SER234 | |
| P | TYR290-SER298 | |
| P | CYS355-ARG367 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36113465, ECO:0007744|PDB:8DKM |
| Chain | Residue | Details |
| P | ASN166 | |
| P | ASN301 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:36113465 |
| Chain | Residue | Details |
| P | ASP205 | |
| P | ASP346 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:36113465 |
| Chain | Residue | Details |
| P | LYS273 | |
| P | LYS280 | |
| P | TYR281 | |
| P | ASP305 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000255, ECO:0000269|PubMed:28082515 |
| Chain | Residue | Details |
| P | ASN36 | |
| P | ASN41 | |
| P | ASN51 | |
| P | ASN84 | |
| P | ASN104 | |
| P | ASN107 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:28082515 |
| Chain | Residue | Details |
| P | ASN66 |
