8DKI
Cryo-EM structure of cystinosin in a lumen-open state
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| B | TYR192-HIS198 | |
| A | TYR200-HIS206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 143 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"36113465","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DKE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DKI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DKX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DYP","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36113465","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 49 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"36113465","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 66 |
| Details | Domain: {"description":"PQ-loop 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 65 |
| Details | Domain: {"description":"PQ-loop 2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36113465","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8DKM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36113465","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36113465","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28082515","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28082515","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
