8DKI
Cryo-EM structure of cystinosin in a lumen-open state
Functional Information from PROSITE/UniProt
site_id | PS00290 |
Number of Residues | 7 |
Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH |
Chain | Residue | Details |
A | TYR200-HIS206 | |
B | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 151 |
Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:36113465 |
Chain | Residue | Details |
P | SER23-ILE125 | |
P | LEU180-ASN202 | |
P | GLY258-LEU263 | |
P | GLY309-GLY331 |
site_id | SWS_FT_FI2 |
Number of Residues | 143 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:36113465, ECO:0007744|PDB:8DKE, ECO:0007744|PDB:8DKI, ECO:0007744|PDB:8DKM, ECO:0007744|PDB:8DKW, ECO:0007744|PDB:8DKX, ECO:0007744|PDB:8DYP |
Chain | Residue | Details |
P | ILE126-TRP150 | |
P | PHE160-GLY179 | |
P | SER203-LEU225 | |
P | TRP235-VAL257 | |
P | GLN264-PHE289 | |
P | ILE299-GLY308 | |
P | ASP332-PHE354 |
site_id | SWS_FT_FI3 |
Number of Residues | 36 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:36113465 |
Chain | Residue | Details |
P | ARG151-SER159 | |
P | TYR226-SER234 | |
P | TYR290-SER298 | |
P | CYS355-ARG367 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:36113465, ECO:0007744|PDB:8DKM |
Chain | Residue | Details |
P | ASN166 | |
P | ASN301 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000305|PubMed:36113465 |
Chain | Residue | Details |
P | ASP205 | |
P | ASP346 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:36113465 |
Chain | Residue | Details |
P | LYS273 | |
P | LYS280 | |
P | TYR281 | |
P | ASP305 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000255, ECO:0000269|PubMed:28082515 |
Chain | Residue | Details |
P | ASN36 | |
P | ASN41 | |
P | ASN51 | |
P | ASN84 | |
P | ASN104 | |
P | ASN107 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:28082515 |
Chain | Residue | Details |
P | ASN66 |