8DGP

14-3-3 epsilon bound to phosphorylated PEAK3 (pS69) peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0001764	biological_process	neuron migration
A	0002753	biological_process	cytoplasmic pattern recognition receptor signaling pathway
A	0003064	biological_process	regulation of heart rate by hormone
A	0003723	molecular_function	RNA binding
A	0004864	molecular_function	protein phosphatase inhibitor activity
A	0005246	molecular_function	calcium channel regulator activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006605	biological_process	protein targeting
A	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
A	0006893	biological_process	Golgi to plasma membrane transport
A	0007165	biological_process	signal transduction
A	0007346	biological_process	regulation of mitotic cell cycle
A	0008104	biological_process	protein localization
A	0015459	molecular_function	potassium channel regulator activity
A	0016020	cellular_component	membrane
A	0019855	molecular_function	calcium channel inhibitor activity
A	0019899	molecular_function	enzyme binding
A	0019903	molecular_function	protein phosphatase binding
A	0019904	molecular_function	protein domain specific binding
A	0021762	biological_process	substantia nigra development
A	0021766	biological_process	hippocampus development
A	0021987	biological_process	cerebral cortex development
A	0023026	molecular_function	MHC class II protein complex binding
A	0030007	biological_process	intracellular potassium ion homeostasis
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031966	cellular_component	mitochondrial membrane
A	0034122	biological_process	negative regulation of toll-like receptor signaling pathway
A	0034123	biological_process	positive regulation of toll-like receptor signaling pathway
A	0034142	biological_process	toll-like receptor 4 signaling pathway
A	0034504	biological_process	protein localization to nucleus
A	0034605	biological_process	cellular response to heat
A	0035329	biological_process	hippo signaling
A	0035332	biological_process	positive regulation of hippo signaling
A	0035556	biological_process	intracellular signal transduction
A	0035591	molecular_function	signaling adaptor activity
A	0042470	cellular_component	melanosome
A	0042802	molecular_function	identical protein binding
A	0042826	molecular_function	histone deacetylase binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0044325	molecular_function	transmembrane transporter binding
A	0045296	molecular_function	cadherin binding
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0046982	molecular_function	protein heterodimerization activity
A	0050815	molecular_function	phosphoserine residue binding
A	0051219	molecular_function	phosphoprotein binding
A	0051480	biological_process	regulation of cytosolic calcium ion concentration
A	0060306	biological_process	regulation of membrane repolarization
A	0070062	cellular_component	extracellular exosome
A	0070972	biological_process	protein localization to endoplasmic reticulum
A	0070979	biological_process	protein K11-linked ubiquitination
A	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
A	0086091	biological_process	regulation of heart rate by cardiac conduction
A	0097110	molecular_function	scaffold protein binding
A	0140311	molecular_function	protein sequestering activity
A	0140678	molecular_function	molecular function inhibitor activity
A	1901379	biological_process	regulation of potassium ion transmembrane transport
A	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
B	0000165	biological_process	MAPK cascade
B	0001764	biological_process	neuron migration
B	0002753	biological_process	cytoplasmic pattern recognition receptor signaling pathway
B	0003064	biological_process	regulation of heart rate by hormone
B	0003723	molecular_function	RNA binding
B	0004864	molecular_function	protein phosphatase inhibitor activity
B	0005246	molecular_function	calcium channel regulator activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006605	biological_process	protein targeting
B	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
B	0006893	biological_process	Golgi to plasma membrane transport
B	0007165	biological_process	signal transduction
B	0007346	biological_process	regulation of mitotic cell cycle
B	0008104	biological_process	protein localization
B	0015459	molecular_function	potassium channel regulator activity
B	0016020	cellular_component	membrane
B	0019855	molecular_function	calcium channel inhibitor activity
B	0019899	molecular_function	enzyme binding
B	0019903	molecular_function	protein phosphatase binding
B	0019904	molecular_function	protein domain specific binding
B	0021762	biological_process	substantia nigra development
B	0021766	biological_process	hippocampus development
B	0021987	biological_process	cerebral cortex development
B	0023026	molecular_function	MHC class II protein complex binding
B	0030007	biological_process	intracellular potassium ion homeostasis
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0031966	cellular_component	mitochondrial membrane
B	0034122	biological_process	negative regulation of toll-like receptor signaling pathway
B	0034123	biological_process	positive regulation of toll-like receptor signaling pathway
B	0034142	biological_process	toll-like receptor 4 signaling pathway
B	0034504	biological_process	protein localization to nucleus
B	0034605	biological_process	cellular response to heat
B	0035329	biological_process	hippo signaling
B	0035332	biological_process	positive regulation of hippo signaling
B	0035556	biological_process	intracellular signal transduction
B	0035591	molecular_function	signaling adaptor activity
B	0042470	cellular_component	melanosome
B	0042802	molecular_function	identical protein binding
B	0042826	molecular_function	histone deacetylase binding
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0044325	molecular_function	transmembrane transporter binding
B	0045296	molecular_function	cadherin binding
B	0046827	biological_process	positive regulation of protein export from nucleus
B	0046982	molecular_function	protein heterodimerization activity
B	0050815	molecular_function	phosphoserine residue binding
B	0051219	molecular_function	phosphoprotein binding
B	0051480	biological_process	regulation of cytosolic calcium ion concentration
B	0060306	biological_process	regulation of membrane repolarization
B	0070062	cellular_component	extracellular exosome
B	0070972	biological_process	protein localization to endoplasmic reticulum
B	0070979	biological_process	protein K11-linked ubiquitination
B	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
B	0086091	biological_process	regulation of heart rate by cardiac conduction
B	0097110	molecular_function	scaffold protein binding
B	0140311	molecular_function	protein sequestering activity
B	0140678	molecular_function	molecular function inhibitor activity
B	1901379	biological_process	regulation of potassium ion transmembrane transport
B	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
C	0000165	biological_process	MAPK cascade
C	0001764	biological_process	neuron migration
C	0002753	biological_process	cytoplasmic pattern recognition receptor signaling pathway
C	0003064	biological_process	regulation of heart rate by hormone
C	0003723	molecular_function	RNA binding
C	0004864	molecular_function	protein phosphatase inhibitor activity
C	0005246	molecular_function	calcium channel regulator activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005925	cellular_component	focal adhesion
C	0006605	biological_process	protein targeting
C	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
C	0006893	biological_process	Golgi to plasma membrane transport
C	0007165	biological_process	signal transduction
C	0007346	biological_process	regulation of mitotic cell cycle
C	0008104	biological_process	protein localization
C	0015459	molecular_function	potassium channel regulator activity
C	0016020	cellular_component	membrane
C	0019855	molecular_function	calcium channel inhibitor activity
C	0019899	molecular_function	enzyme binding
C	0019903	molecular_function	protein phosphatase binding
C	0019904	molecular_function	protein domain specific binding
C	0021762	biological_process	substantia nigra development
C	0021766	biological_process	hippocampus development
C	0021987	biological_process	cerebral cortex development
C	0023026	molecular_function	MHC class II protein complex binding
C	0030007	biological_process	intracellular potassium ion homeostasis
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031966	cellular_component	mitochondrial membrane
C	0034122	biological_process	negative regulation of toll-like receptor signaling pathway
C	0034123	biological_process	positive regulation of toll-like receptor signaling pathway
C	0034142	biological_process	toll-like receptor 4 signaling pathway
C	0034504	biological_process	protein localization to nucleus
C	0034605	biological_process	cellular response to heat
C	0035329	biological_process	hippo signaling
C	0035332	biological_process	positive regulation of hippo signaling
C	0035556	biological_process	intracellular signal transduction
C	0035591	molecular_function	signaling adaptor activity
C	0042470	cellular_component	melanosome
C	0042802	molecular_function	identical protein binding
C	0042826	molecular_function	histone deacetylase binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0044325	molecular_function	transmembrane transporter binding
C	0045296	molecular_function	cadherin binding
C	0046827	biological_process	positive regulation of protein export from nucleus
C	0046982	molecular_function	protein heterodimerization activity
C	0050815	molecular_function	phosphoserine residue binding
C	0051219	molecular_function	phosphoprotein binding
C	0051480	biological_process	regulation of cytosolic calcium ion concentration
C	0060306	biological_process	regulation of membrane repolarization
C	0070062	cellular_component	extracellular exosome
C	0070972	biological_process	protein localization to endoplasmic reticulum
C	0070979	biological_process	protein K11-linked ubiquitination
C	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
C	0086091	biological_process	regulation of heart rate by cardiac conduction
C	0097110	molecular_function	scaffold protein binding
C	0140311	molecular_function	protein sequestering activity
C	0140678	molecular_function	molecular function inhibitor activity
C	1901379	biological_process	regulation of potassium ion transmembrane transport
C	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
D	0000165	biological_process	MAPK cascade
D	0001764	biological_process	neuron migration
D	0002753	biological_process	cytoplasmic pattern recognition receptor signaling pathway
D	0003064	biological_process	regulation of heart rate by hormone
D	0003723	molecular_function	RNA binding
D	0004864	molecular_function	protein phosphatase inhibitor activity
D	0005246	molecular_function	calcium channel regulator activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006605	biological_process	protein targeting
D	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
D	0006893	biological_process	Golgi to plasma membrane transport
D	0007165	biological_process	signal transduction
D	0007346	biological_process	regulation of mitotic cell cycle
D	0008104	biological_process	protein localization
D	0015459	molecular_function	potassium channel regulator activity
D	0016020	cellular_component	membrane
D	0019855	molecular_function	calcium channel inhibitor activity
D	0019899	molecular_function	enzyme binding
D	0019903	molecular_function	protein phosphatase binding
D	0019904	molecular_function	protein domain specific binding
D	0021762	biological_process	substantia nigra development
D	0021766	biological_process	hippocampus development
D	0021987	biological_process	cerebral cortex development
D	0023026	molecular_function	MHC class II protein complex binding
D	0030007	biological_process	intracellular potassium ion homeostasis
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031966	cellular_component	mitochondrial membrane
D	0034122	biological_process	negative regulation of toll-like receptor signaling pathway
D	0034123	biological_process	positive regulation of toll-like receptor signaling pathway
D	0034142	biological_process	toll-like receptor 4 signaling pathway
D	0034504	biological_process	protein localization to nucleus
D	0034605	biological_process	cellular response to heat
D	0035329	biological_process	hippo signaling
D	0035332	biological_process	positive regulation of hippo signaling
D	0035556	biological_process	intracellular signal transduction
D	0035591	molecular_function	signaling adaptor activity
D	0042470	cellular_component	melanosome
D	0042802	molecular_function	identical protein binding
D	0042826	molecular_function	histone deacetylase binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0044325	molecular_function	transmembrane transporter binding
D	0045296	molecular_function	cadherin binding
D	0046827	biological_process	positive regulation of protein export from nucleus
D	0046982	molecular_function	protein heterodimerization activity
D	0050815	molecular_function	phosphoserine residue binding
D	0051219	molecular_function	phosphoprotein binding
D	0051480	biological_process	regulation of cytosolic calcium ion concentration
D	0060306	biological_process	regulation of membrane repolarization
D	0070062	cellular_component	extracellular exosome
D	0070972	biological_process	protein localization to endoplasmic reticulum
D	0070979	biological_process	protein K11-linked ubiquitination
D	0086013	biological_process	membrane repolarization during cardiac muscle cell action potential
D	0086091	biological_process	regulation of heart rate by cardiac conduction
D	0097110	molecular_function	scaffold protein binding
D	0140311	molecular_function	protein sequestering activity
D	0140678	molecular_function	molecular function inhibitor activity
D	1901379	biological_process	regulation of potassium ion transmembrane transport
D	1905913	biological_process	negative regulation of calcium ion export across plasma membrane

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG42-VAL52

---

site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
A	TYR214-SER233

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Site: {"description":"Interaction with phosphoserine on interacting protein"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2005","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P62260","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62260","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62260","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---