8DEP
Cryo-EM structure of the human reduced folate carrier, apo condition
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008518 | molecular_function | folate:monoatomic anion antiporter activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0015350 | molecular_function | methotrexate transmembrane transporter activity |
| A | 0015884 | biological_process | folic acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051180 | biological_process | vitamin transport |
| A | 0051958 | biological_process | methotrexate transport |
| A | 0090482 | molecular_function | vitamin transmembrane transporter activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 197 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:10347183 |
| Chain | Residue | Details |
| A | MET1-ARG23 | |
| A | LEU90-VAL95 | |
| A | ARG145-ALA159 | |
| A | LYS328-ARG333 | |
| A | LEU379-GLU394 | |
| A | LEU455-GLN591 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000305 |
| Chain | Residue | Details |
| A | SER24-GLY44 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 78 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:10347183 |
| Chain | Residue | Details |
| A | GLU45-PRO70 | |
| A | ALA117-GLU123 | |
| A | GLY178-ASN186 | |
| A | VAL288-ALA309 | |
| A | HIS355-SER360 | |
| A | ASP420-GLN433 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000305 |
| Chain | Residue | Details |
| A | VAL71-TYR89 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000305 |
| Chain | Residue | Details |
| A | LEU96-VAL116 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000305 |
| Chain | Residue | Details |
| A | LEU124-VAL144 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000305 |
| Chain | Residue | Details |
| A | VAL160-VAL177 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000305 |
| Chain | Residue | Details |
| A | TYR187-LEU203 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000305 |
| Chain | Residue | Details |
| A | ASP260-TYR287 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000305 |
| Chain | Residue | Details |
| A | ASP310-VAL327 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000305 |
| Chain | Residue | Details |
| A | TRP334-ALA354 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000305 |
| Chain | Residue | Details |
| A | SER361-PHE378 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000305 |
| Chain | Residue | Details |
| A | LEU395-SER419 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000305 |
| Chain | Residue | Details |
| A | LEU434-GLY454 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| A | MET1 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER5 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P41438 |
| Chain | Residue | Details |
| A | SER474 | |
| A | SER485 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| A | SER499 | |
| A | SER503 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:9767079 |
| Chain | Residue | Details |
| A | ASN58 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | TRP211 | |
| A | ILE214 |
