8DD0

The structure of the native cardiac thin filament junction region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001725	cellular_component	stress fiber
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005865	cellular_component	striated muscle thin filament
A	0005884	cellular_component	actin filament
A	0010628	biological_process	positive regulation of gene expression
A	0016787	molecular_function	hydrolase activity
A	0030027	cellular_component	lamellipodium
A	0030175	cellular_component	filopodium
A	0030240	biological_process	skeletal muscle thin filament assembly
A	0044297	cellular_component	cell body
A	0048741	biological_process	skeletal muscle fiber development
A	0090131	biological_process	mesenchyme migration
B	0000166	molecular_function	nucleotide binding
B	0001725	cellular_component	stress fiber
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005865	cellular_component	striated muscle thin filament
B	0005884	cellular_component	actin filament
B	0010628	biological_process	positive regulation of gene expression
B	0016787	molecular_function	hydrolase activity
B	0030027	cellular_component	lamellipodium
B	0030175	cellular_component	filopodium
B	0030240	biological_process	skeletal muscle thin filament assembly
B	0044297	cellular_component	cell body
B	0048741	biological_process	skeletal muscle fiber development
B	0090131	biological_process	mesenchyme migration
C	0000166	molecular_function	nucleotide binding
C	0001725	cellular_component	stress fiber
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005865	cellular_component	striated muscle thin filament
C	0005884	cellular_component	actin filament
C	0010628	biological_process	positive regulation of gene expression
C	0016787	molecular_function	hydrolase activity
C	0030027	cellular_component	lamellipodium
C	0030175	cellular_component	filopodium
C	0030240	biological_process	skeletal muscle thin filament assembly
C	0044297	cellular_component	cell body
C	0048741	biological_process	skeletal muscle fiber development
C	0090131	biological_process	mesenchyme migration
D	0000166	molecular_function	nucleotide binding
D	0001725	cellular_component	stress fiber
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005865	cellular_component	striated muscle thin filament
D	0005884	cellular_component	actin filament
D	0010628	biological_process	positive regulation of gene expression
D	0016787	molecular_function	hydrolase activity
D	0030027	cellular_component	lamellipodium
D	0030175	cellular_component	filopodium
D	0030240	biological_process	skeletal muscle thin filament assembly
D	0044297	cellular_component	cell body
D	0048741	biological_process	skeletal muscle fiber development
D	0090131	biological_process	mesenchyme migration
E	0000166	molecular_function	nucleotide binding
E	0001725	cellular_component	stress fiber
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005865	cellular_component	striated muscle thin filament
E	0005884	cellular_component	actin filament
E	0010628	biological_process	positive regulation of gene expression
E	0016787	molecular_function	hydrolase activity
E	0030027	cellular_component	lamellipodium
E	0030175	cellular_component	filopodium
E	0030240	biological_process	skeletal muscle thin filament assembly
E	0044297	cellular_component	cell body
E	0048741	biological_process	skeletal muscle fiber development
E	0090131	biological_process	mesenchyme migration
F	0000166	molecular_function	nucleotide binding
F	0001725	cellular_component	stress fiber
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005865	cellular_component	striated muscle thin filament
F	0005884	cellular_component	actin filament
F	0010628	biological_process	positive regulation of gene expression
F	0016787	molecular_function	hydrolase activity
F	0030027	cellular_component	lamellipodium
F	0030175	cellular_component	filopodium
F	0030240	biological_process	skeletal muscle thin filament assembly
F	0044297	cellular_component	cell body
F	0048741	biological_process	skeletal muscle fiber development
F	0090131	biological_process	mesenchyme migration
G	0003779	molecular_function	actin binding
G	0005856	cellular_component	cytoskeleton
G	0005884	cellular_component	actin filament
G	0007015	biological_process	actin filament organization
G	0015629	cellular_component	actin cytoskeleton
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0046982	molecular_function	protein heterodimerization activity
G	0051015	molecular_function	actin filament binding
G	0060048	biological_process	cardiac muscle contraction
H	0003779	molecular_function	actin binding
H	0005856	cellular_component	cytoskeleton
H	0005884	cellular_component	actin filament
H	0007015	biological_process	actin filament organization
H	0015629	cellular_component	actin cytoskeleton
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0046982	molecular_function	protein heterodimerization activity
H	0051015	molecular_function	actin filament binding
H	0060048	biological_process	cardiac muscle contraction
I	0003779	molecular_function	actin binding
I	0005856	cellular_component	cytoskeleton
I	0005884	cellular_component	actin filament
I	0007015	biological_process	actin filament organization
I	0015629	cellular_component	actin cytoskeleton
I	0042802	molecular_function	identical protein binding
I	0042803	molecular_function	protein homodimerization activity
I	0046982	molecular_function	protein heterodimerization activity
I	0051015	molecular_function	actin filament binding
I	0060048	biological_process	cardiac muscle contraction
J	0003779	molecular_function	actin binding
J	0005856	cellular_component	cytoskeleton
J	0005884	cellular_component	actin filament
J	0007015	biological_process	actin filament organization
J	0015629	cellular_component	actin cytoskeleton
J	0042802	molecular_function	identical protein binding
J	0042803	molecular_function	protein homodimerization activity
J	0046982	molecular_function	protein heterodimerization activity
J	0051015	molecular_function	actin filament binding
J	0060048	biological_process	cardiac muscle contraction
K	0003779	molecular_function	actin binding
K	0005523	molecular_function	tropomyosin binding
K	0005861	cellular_component	troponin complex
K	0005865	cellular_component	striated muscle thin filament
K	0006937	biological_process	regulation of muscle contraction
K	0008016	biological_process	regulation of heart contraction
K	0030049	biological_process	muscle filament sliding
K	0030172	molecular_function	troponin C binding
K	0031013	molecular_function	troponin I binding
K	0045214	biological_process	sarcomere organization
K	0051592	biological_process	response to calcium ion
K	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
K	0060048	biological_process	cardiac muscle contraction
K	0097512	cellular_component	cardiac myofibril
K	1990584	cellular_component	cardiac Troponin complex
L	0003779	molecular_function	actin binding
L	0005856	cellular_component	cytoskeleton
L	0005884	cellular_component	actin filament
L	0007015	biological_process	actin filament organization
L	0015629	cellular_component	actin cytoskeleton
L	0042802	molecular_function	identical protein binding
L	0042803	molecular_function	protein homodimerization activity
L	0046982	molecular_function	protein heterodimerization activity
L	0051015	molecular_function	actin filament binding
L	0060048	biological_process	cardiac muscle contraction
M	0003779	molecular_function	actin binding
M	0005856	cellular_component	cytoskeleton
M	0005884	cellular_component	actin filament
M	0007015	biological_process	actin filament organization
M	0015629	cellular_component	actin cytoskeleton
M	0042802	molecular_function	identical protein binding
M	0042803	molecular_function	protein homodimerization activity
M	0046982	molecular_function	protein heterodimerization activity
M	0051015	molecular_function	actin filament binding
M	0060048	biological_process	cardiac muscle contraction
N	0003779	molecular_function	actin binding
N	0005856	cellular_component	cytoskeleton
N	0005884	cellular_component	actin filament
N	0007015	biological_process	actin filament organization
N	0015629	cellular_component	actin cytoskeleton
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0046982	molecular_function	protein heterodimerization activity
N	0051015	molecular_function	actin filament binding
N	0060048	biological_process	cardiac muscle contraction
O	0003779	molecular_function	actin binding
O	0005856	cellular_component	cytoskeleton
O	0005884	cellular_component	actin filament
O	0007015	biological_process	actin filament organization
O	0015629	cellular_component	actin cytoskeleton
O	0042802	molecular_function	identical protein binding
O	0042803	molecular_function	protein homodimerization activity
O	0046982	molecular_function	protein heterodimerization activity
O	0051015	molecular_function	actin filament binding
O	0060048	biological_process	cardiac muscle contraction
P	0003779	molecular_function	actin binding
P	0005523	molecular_function	tropomyosin binding
P	0005861	cellular_component	troponin complex
P	0005865	cellular_component	striated muscle thin filament
P	0006937	biological_process	regulation of muscle contraction
P	0008016	biological_process	regulation of heart contraction
P	0030049	biological_process	muscle filament sliding
P	0030172	molecular_function	troponin C binding
P	0031013	molecular_function	troponin I binding
P	0045214	biological_process	sarcomere organization
P	0051592	biological_process	response to calcium ion
P	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
P	0060048	biological_process	cardiac muscle contraction
P	0097512	cellular_component	cardiac myofibril
P	1990584	cellular_component	cardiac Troponin complex

Functional Information from PROSITE/UniProt

site_id	PS00326
Number of Residues	9
Details	TROPOMYOSIN Tropomyosins signature. LKEAEtRAE

Chain	Residue	Details
G	LEU232-GLU240

---

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
A	TYR53-GLY63

---

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WISKqEYDE

Chain	Residue	Details
A	TRP356-GLU364

---

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR

Chain	Residue	Details
A	LEU104-ARG116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	150
Details	Region: {"description":"Interaction with alpha-actinin","evidences":[{"source":"UniProtKB","id":"P68135","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68134","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Modified residue: {"description":"N6-malonyllysine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P68138","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68133","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P58771","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P04692","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by DAPK1","evidences":[{"source":"UniProtKB","id":"P09493","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	100
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"P09493","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P04692","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---