Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8DBV

E. coli ATP synthase imaged in 10mM MgATP State3 "down

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006754	biological_process	ATP biosynthetic process
A	0006811	biological_process	monoatomic ion transport
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
A	0043531	molecular_function	ADP binding
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006754	biological_process	ATP biosynthetic process
B	0006811	biological_process	monoatomic ion transport
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
B	0043531	molecular_function	ADP binding
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0006754	biological_process	ATP biosynthetic process
C	0006811	biological_process	monoatomic ion transport
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
C	0043531	molecular_function	ADP binding
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0006754	biological_process	ATP biosynthetic process
D	0006811	biological_process	monoatomic ion transport
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016020	cellular_component	membrane
D	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0000166	molecular_function	nucleotide binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005886	cellular_component	plasma membrane
E	0006754	biological_process	ATP biosynthetic process
E	0006811	biological_process	monoatomic ion transport
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0000166	molecular_function	nucleotide binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005886	cellular_component	plasma membrane
F	0006754	biological_process	ATP biosynthetic process
F	0006811	biological_process	monoatomic ion transport
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016020	cellular_component	membrane
F	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005886	cellular_component	plasma membrane
G	0006754	biological_process	ATP biosynthetic process
G	0006811	biological_process	monoatomic ion transport
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0016020	cellular_component	membrane
G	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
G	0045259	cellular_component	proton-transporting ATP synthase complex
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005886	cellular_component	plasma membrane
H	0006754	biological_process	ATP biosynthetic process
H	0006811	biological_process	monoatomic ion transport
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0016020	cellular_component	membrane
H	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
H	0045259	cellular_component	proton-transporting ATP synthase complex
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport
I	0005886	cellular_component	plasma membrane
I	0006754	biological_process	ATP biosynthetic process
I	0006811	biological_process	monoatomic ion transport
I	0008289	molecular_function	lipid binding
I	0015078	molecular_function	proton transmembrane transporter activity
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0016020	cellular_component	membrane
I	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
I	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
I	0045259	cellular_component	proton-transporting ATP synthase complex
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0005886	cellular_component	plasma membrane
J	0006754	biological_process	ATP biosynthetic process
J	0006811	biological_process	monoatomic ion transport
J	0008289	molecular_function	lipid binding
J	0015078	molecular_function	proton transmembrane transporter activity
J	0015986	biological_process	proton motive force-driven ATP synthesis
J	0016020	cellular_component	membrane
J	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
J	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
J	0045259	cellular_component	proton-transporting ATP synthase complex
J	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
J	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
J	1902600	biological_process	proton transmembrane transport
L	0005886	cellular_component	plasma membrane
L	0006754	biological_process	ATP biosynthetic process
L	0006811	biological_process	monoatomic ion transport
L	0008289	molecular_function	lipid binding
L	0015078	molecular_function	proton transmembrane transporter activity
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0016020	cellular_component	membrane
L	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
L	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
L	0045259	cellular_component	proton-transporting ATP synthase complex
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0005886	cellular_component	plasma membrane
M	0006754	biological_process	ATP biosynthetic process
M	0006811	biological_process	monoatomic ion transport
M	0008289	molecular_function	lipid binding
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0016020	cellular_component	membrane
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
M	0045259	cellular_component	proton-transporting ATP synthase complex
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0005886	cellular_component	plasma membrane
N	0006754	biological_process	ATP biosynthetic process
N	0006811	biological_process	monoatomic ion transport
N	0008289	molecular_function	lipid binding
N	0015078	molecular_function	proton transmembrane transporter activity
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0016020	cellular_component	membrane
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
N	0045259	cellular_component	proton-transporting ATP synthase complex
N	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
N	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
N	1902600	biological_process	proton transmembrane transport
O	0005886	cellular_component	plasma membrane
O	0006754	biological_process	ATP biosynthetic process
O	0006811	biological_process	monoatomic ion transport
O	0008289	molecular_function	lipid binding
O	0015078	molecular_function	proton transmembrane transporter activity
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0016020	cellular_component	membrane
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
O	0045259	cellular_component	proton-transporting ATP synthase complex
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
O	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport
P	0005886	cellular_component	plasma membrane
P	0006754	biological_process	ATP biosynthetic process
P	0006811	biological_process	monoatomic ion transport
P	0008289	molecular_function	lipid binding
P	0015078	molecular_function	proton transmembrane transporter activity
P	0015986	biological_process	proton motive force-driven ATP synthesis
P	0016020	cellular_component	membrane
P	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
P	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
P	0045259	cellular_component	proton-transporting ATP synthase complex
P	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
P	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
Q	0005886	cellular_component	plasma membrane
Q	0006754	biological_process	ATP biosynthetic process
Q	0006811	biological_process	monoatomic ion transport
Q	0008289	molecular_function	lipid binding
Q	0015078	molecular_function	proton transmembrane transporter activity
Q	0015986	biological_process	proton motive force-driven ATP synthesis
Q	0016020	cellular_component	membrane
Q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Q	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
Q	0045259	cellular_component	proton-transporting ATP synthase complex
Q	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
Q	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Q	1902600	biological_process	proton transmembrane transport
R	0005886	cellular_component	plasma membrane
R	0006754	biological_process	ATP biosynthetic process
R	0006811	biological_process	monoatomic ion transport
R	0008289	molecular_function	lipid binding
R	0015078	molecular_function	proton transmembrane transporter activity
R	0015986	biological_process	proton motive force-driven ATP synthesis
R	0016020	cellular_component	membrane
R	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
R	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
R	0045259	cellular_component	proton-transporting ATP synthase complex
R	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
R	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
R	1902600	biological_process	proton transmembrane transport
S	0005886	cellular_component	plasma membrane
S	0006754	biological_process	ATP biosynthetic process
S	0006811	biological_process	monoatomic ion transport
S	0008289	molecular_function	lipid binding
S	0015078	molecular_function	proton transmembrane transporter activity
S	0015986	biological_process	proton motive force-driven ATP synthesis
S	0016020	cellular_component	membrane
S	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
S	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
S	0045259	cellular_component	proton-transporting ATP synthase complex
S	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
S	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
S	1902600	biological_process	proton transmembrane transport
W	0005886	cellular_component	plasma membrane
W	0006754	biological_process	ATP biosynthetic process
W	0006811	biological_process	monoatomic ion transport
W	0015986	biological_process	proton motive force-driven ATP synthesis
W	0016020	cellular_component	membrane
W	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
W	0045259	cellular_component	proton-transporting ATP synthase complex
W	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
W	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
W	1902600	biological_process	proton transmembrane transport
X	0005886	cellular_component	plasma membrane
X	0006754	biological_process	ATP biosynthetic process
X	0006811	biological_process	monoatomic ion transport
X	0015078	molecular_function	proton transmembrane transporter activity
X	0015986	biological_process	proton motive force-driven ATP synthesis
X	0016020	cellular_component	membrane
X	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
X	0045259	cellular_component	proton-transporting ATP synthase complex
X	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
X	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
X	1902600	biological_process	proton transmembrane transport
Y	0005886	cellular_component	plasma membrane
Y	0006754	biological_process	ATP biosynthetic process
Y	0006811	biological_process	monoatomic ion transport
Y	0015078	molecular_function	proton transmembrane transporter activity
Y	0015986	biological_process	proton motive force-driven ATP synthesis
Y	0016020	cellular_component	membrane
Y	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
Y	0045259	cellular_component	proton-transporting ATP synthase complex
Y	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
Y	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Y	1902600	biological_process	proton transmembrane transport
a	0005886	cellular_component	plasma membrane
a	0006754	biological_process	ATP biosynthetic process
a	0006811	biological_process	monoatomic ion transport
a	0015078	molecular_function	proton transmembrane transporter activity
a	0015986	biological_process	proton motive force-driven ATP synthesis
a	0016020	cellular_component	membrane
a	0042777	biological_process	proton motive force-driven plasma membrane ATP synthesis
a	0045259	cellular_component	proton-transporting ATP synthase complex
a	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
a	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
a	1902600	biological_process	proton transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVNPGISVS

Chain	Residue	Details
A	PRO366-SER375
D	PRO332-SER341

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITqEltEivsGAaA

Chain	Residue	Details
G	ILE272-ALA285

site_id	PS00389
Number of Residues	20
Details	ATPASE_DELTA ATP synthase delta (OSCP) subunit signature. VkLnakIDkSVmAGVIIRaG

Chain	Residue	Details
W	VAL136-GLY155

site_id	PS00449
Number of Residues	10
Details	ATPASE_A ATP synthase a subunit signature. SLGLRLFGNM

Chain	Residue	Details
a	SER206-MET215

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. ARQPdliplLrTqfFIvmgLvD

Chain	Residue	Details
I	ALA40-ASP61

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	3
Details	Site: {"description":"Required for activity"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	21
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01347","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	400
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	200
Details	Topological domain: {"description":"Cytoplasmic"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	45
Details	Topological domain: {"description":"Periplasmic"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	10
Details	Site: {"description":"Reversibly protonated during proton transport"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	40
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01398","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Site: {"description":"Mutation prevents the formation of a functional proton pore, but has a small effect on the binding of F(1) to F(0)"}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Site: {"description":"Required for proton pore formation, as well as F(1) to F(0) binding"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	100
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	90
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	25
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 507

Chain	Residue	Details
J	ASP61	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA10
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
S	ASP61	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA2
Number of Residues	1
Details	M-CSA 507

Chain

Residue

Details

site_id	MCSA3
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
L	ASP61	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA4
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
M	ASP61	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA5
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
N	ASP61	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA6
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
O	ASP61	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA7
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
P	ASP61	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA8
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
Q	ASP61	electrostatic stabiliser, proton acceptor, proton donor

site_id	MCSA9
Number of Residues	1
Details	M-CSA 507

Chain	Residue	Details
R	ASP61	electrostatic stabiliser, proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)