8DAE

Arabidopsis thaliana bifunctional dihydrofolate reductase-thymidylate synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004146	molecular_function	dihydrofolate reductase activity
A	0004799	molecular_function	thymidylate synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006231	biological_process	dTMP biosynthetic process
A	0006730	biological_process	one-carbon metabolic process
A	0008168	molecular_function	methyltransferase activity
A	0009165	biological_process	nucleotide biosynthetic process
A	0009257	biological_process	10-formyltetrahydrofolate biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016741	molecular_function	transferase activity, transferring one-carbon groups
A	0032259	biological_process	methylation
A	0046654	biological_process	tetrahydrofolate biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00075
Number of Residues	23
Details	DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGkdgkLPWnlpt.DlkfFkdiT

Chain	Residue	Details
A	GLY33-THR55

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site_id	PS00091
Number of Residues	29
Details	THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImsaWNpsdlklma.....LpPCHmfaQFyV

Chain	Residue	Details
A	ARG381-VAL409

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	CYS401

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site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	VAL25
A	ARG256
A	HIS402
A	GLN420
A	ASN432
A	HIS462
A	ALA27
A	GLY33
A	ASP47
A	ARG71
A	LEU92
A	ILE134
A	GLY135
A	THR155

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:22223895

Chain	Residue	Details
A	ALA2

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