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8D9W

beta-Arf1 homodimeric interface within AP-1, Arf1, Nef, MHC-I lattice on narrow tubes

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
a0005515molecular_functionprotein binding
a0005765cellular_componentlysosomal membrane
a0005769cellular_componentearly endosome
a0005794cellular_componentGolgi apparatus
a0005802cellular_componenttrans-Golgi network
a0005829cellular_componentcytosol
a0006886biological_processintracellular protein transport
a0006896biological_processGolgi to vacuole transport
a0015031biological_processprotein transport
a0016192biological_processvesicle-mediated transport
a0030121cellular_componentAP-1 adaptor complex
a0030131cellular_componentclathrin adaptor complex
a0030665cellular_componentclathrin-coated vesicle membrane
a0031410cellular_componentcytoplasmic vesicle
a0032438biological_processmelanosome organization
a0032588cellular_componenttrans-Golgi network membrane
a0035615molecular_functionclathrin adaptor activity
a0035646biological_processendosome to melanosome transport
a0045202cellular_componentsynapse
a0060155biological_processplatelet dense granule organization
a1903232biological_processmelanosome assembly
A0000139cellular_componentGolgi membrane
A0005515molecular_functionprotein binding
A0005765cellular_componentlysosomal membrane
A0005769cellular_componentearly endosome
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006886biological_processintracellular protein transport
A0008021cellular_componentsynaptic vesicle
A0012505cellular_componentendomembrane system
A0015031biological_processprotein transport
A0016192biological_processvesicle-mediated transport
A0019901molecular_functionprotein kinase binding
A0030117cellular_componentmembrane coat
A0030131cellular_componentclathrin adaptor complex
A0030276molecular_functionclathrin binding
A0030659cellular_componentcytoplasmic vesicle membrane
A0030665cellular_componentclathrin-coated vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0032588cellular_componenttrans-Golgi network membrane
A0060155biological_processplatelet dense granule organization
A0110010biological_processbasolateral protein secretion
A1903232biological_processmelanosome assembly
B0000139cellular_componentGolgi membrane
B0005515molecular_functionprotein binding
B0005765cellular_componentlysosomal membrane
B0005769cellular_componentearly endosome
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006886biological_processintracellular protein transport
B0008021cellular_componentsynaptic vesicle
B0012505cellular_componentendomembrane system
B0015031biological_processprotein transport
B0016192biological_processvesicle-mediated transport
B0019901molecular_functionprotein kinase binding
B0030117cellular_componentmembrane coat
B0030131cellular_componentclathrin adaptor complex
B0030276molecular_functionclathrin binding
B0030659cellular_componentcytoplasmic vesicle membrane
B0030665cellular_componentclathrin-coated vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0032588cellular_componenttrans-Golgi network membrane
B0060155biological_processplatelet dense granule organization
B0110010biological_processbasolateral protein secretion
B1903232biological_processmelanosome assembly
d0005102molecular_functionsignaling receptor binding
d0005515molecular_functionprotein binding
d0005525molecular_functionGTP binding
d0005576cellular_componentextracellular region
d0010561biological_processnegative regulation of glycoprotein biosynthetic process
d0016020cellular_componentmembrane
d0017124molecular_functionSH3 domain binding
d0019058biological_processviral life cycle
d0019901molecular_functionprotein kinase binding
d0020002cellular_componenthost cell plasma membrane
d0031996molecular_functionthioesterase binding
d0033668biological_processsymbiont-mediated suppression of host apoptosis
d0039504biological_processsymbiont-mediated suppression of host adaptive immune response
d0039505biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
d0042288molecular_functionMHC class I protein binding
d0042609molecular_functionCD4 receptor binding
d0044178cellular_componenthost cell Golgi membrane
d0044423cellular_componentvirion component
d0046776biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
d0050848biological_processregulation of calcium-mediated signaling
d0051117molecular_functionATPase binding
d0051246biological_processregulation of protein metabolic process
d0051701biological_processbiological process involved in interaction with host
d0052031biological_processsymbiont-mediated perturbation of host defense response
d0052170biological_processsymbiont-mediated suppression of host innate immune response
d0070206biological_processprotein trimerization
d0140321biological_processsymbiont-mediated suppression of host autophagy
D0000139cellular_componentGolgi membrane
D0005515molecular_functionprotein binding
D0005765cellular_componentlysosomal membrane
D0005769cellular_componentearly endosome
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0006886biological_processintracellular protein transport
D0008021cellular_componentsynaptic vesicle
D0012505cellular_componentendomembrane system
D0015031biological_processprotein transport
D0016192biological_processvesicle-mediated transport
D0019901molecular_functionprotein kinase binding
D0030117cellular_componentmembrane coat
D0030131cellular_componentclathrin adaptor complex
D0030276molecular_functionclathrin binding
D0030659cellular_componentcytoplasmic vesicle membrane
D0030665cellular_componentclathrin-coated vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0032588cellular_componenttrans-Golgi network membrane
D0060155biological_processplatelet dense granule organization
D0110010biological_processbasolateral protein secretion
D1903232biological_processmelanosome assembly
e0000139cellular_componentGolgi membrane
e0005515molecular_functionprotein binding
e0005765cellular_componentlysosomal membrane
e0005769cellular_componentearly endosome
e0005794cellular_componentGolgi apparatus
e0005829cellular_componentcytosol
e0005905cellular_componentclathrin-coated pit
e0006605biological_processprotein targeting
e0006886biological_processintracellular protein transport
e0015031biological_processprotein transport
e0016192biological_processvesicle-mediated transport
e0030117cellular_componentmembrane coat
e0030121cellular_componentAP-1 adaptor complex
e0030659cellular_componentcytoplasmic vesicle membrane
e0031410cellular_componentcytoplasmic vesicle
e0032588cellular_componenttrans-Golgi network membrane
e0035615molecular_functionclathrin adaptor activity
e0060155biological_processplatelet dense granule organization
e1903232biological_processmelanosome assembly
E0000139cellular_componentGolgi membrane
E0005515molecular_functionprotein binding
E0005765cellular_componentlysosomal membrane
E0005769cellular_componentearly endosome
E0005794cellular_componentGolgi apparatus
E0005829cellular_componentcytosol
E0006886biological_processintracellular protein transport
E0008021cellular_componentsynaptic vesicle
E0012505cellular_componentendomembrane system
E0015031biological_processprotein transport
E0016192biological_processvesicle-mediated transport
E0019901molecular_functionprotein kinase binding
E0030117cellular_componentmembrane coat
E0030131cellular_componentclathrin adaptor complex
E0030276molecular_functionclathrin binding
E0030659cellular_componentcytoplasmic vesicle membrane
E0030665cellular_componentclathrin-coated vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0032588cellular_componenttrans-Golgi network membrane
E0060155biological_processplatelet dense granule organization
E0110010biological_processbasolateral protein secretion
E1903232biological_processmelanosome assembly
f0000139cellular_componentGolgi membrane
f0005515molecular_functionprotein binding
f0005765cellular_componentlysosomal membrane
f0005769cellular_componentearly endosome
f0005794cellular_componentGolgi apparatus
f0005829cellular_componentcytosol
f0005905cellular_componentclathrin-coated pit
f0006605biological_processprotein targeting
f0006886biological_processintracellular protein transport
f0015031biological_processprotein transport
f0016192biological_processvesicle-mediated transport
f0030117cellular_componentmembrane coat
f0030121cellular_componentAP-1 adaptor complex
f0030659cellular_componentcytoplasmic vesicle membrane
f0031410cellular_componentcytoplasmic vesicle
f0032588cellular_componenttrans-Golgi network membrane
f0035615molecular_functionclathrin adaptor activity
f0060155biological_processplatelet dense granule organization
f1903232biological_processmelanosome assembly
F0000139cellular_componentGolgi membrane
F0000166molecular_functionnucleotide binding
F0000287molecular_functionmagnesium ion binding
F0002090biological_processregulation of receptor internalization
F0003723molecular_functionRNA binding
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005737cellular_componentcytoplasm
F0005794cellular_componentGolgi apparatus
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0006878biological_processintracellular copper ion homeostasis
F0006886biological_processintracellular protein transport
F0012505cellular_componentendomembrane system
F0014069cellular_componentpostsynaptic density
F0015031biological_processprotein transport
F0016192biological_processvesicle-mediated transport
F0016787molecular_functionhydrolase activity
F0019904molecular_functionprotein domain specific binding
F0030017cellular_componentsarcomere
F0031252cellular_componentcell leading edge
F0032991cellular_componentprotein-containing complex
F0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
F0043005cellular_componentneuron projection
F0045202cellular_componentsynapse
F0060292biological_processlong-term synaptic depression
F0070062cellular_componentextracellular exosome
F0097061biological_processdendritic spine organization
F0098586biological_processcellular response to virus
F1990386biological_processmitotic cleavage furrow ingression
I0000139cellular_componentGolgi membrane
I0000166molecular_functionnucleotide binding
I0000287molecular_functionmagnesium ion binding
I0002090biological_processregulation of receptor internalization
I0003723molecular_functionRNA binding
I0003924molecular_functionGTPase activity
I0003925molecular_functionG protein activity
I0005515molecular_functionprotein binding
I0005525molecular_functionGTP binding
I0005737cellular_componentcytoplasm
I0005794cellular_componentGolgi apparatus
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0005925cellular_componentfocal adhesion
I0006878biological_processintracellular copper ion homeostasis
I0006886biological_processintracellular protein transport
I0012505cellular_componentendomembrane system
I0014069cellular_componentpostsynaptic density
I0015031biological_processprotein transport
I0016192biological_processvesicle-mediated transport
I0016787molecular_functionhydrolase activity
I0019904molecular_functionprotein domain specific binding
I0030017cellular_componentsarcomere
I0031252cellular_componentcell leading edge
I0032991cellular_componentprotein-containing complex
I0034315biological_processregulation of Arp2/3 complex-mediated actin nucleation
I0043005cellular_componentneuron projection
I0045202cellular_componentsynapse
I0060292biological_processlong-term synaptic depression
I0070062cellular_componentextracellular exosome
I0097061biological_processdendritic spine organization
I0098586biological_processcellular response to virus
I1990386biological_processmitotic cleavage furrow ingression
j0006955biological_processimmune response
j0019882biological_processantigen processing and presentation
K0006886biological_processintracellular protein transport
K0016192biological_processvesicle-mediated transport
K0030117cellular_componentmembrane coat
M0005515molecular_functionprotein binding
M0005765cellular_componentlysosomal membrane
M0005769cellular_componentearly endosome
M0005794cellular_componentGolgi apparatus
M0005802cellular_componenttrans-Golgi network
M0005829cellular_componentcytosol
M0006886biological_processintracellular protein transport
M0006896biological_processGolgi to vacuole transport
M0015031biological_processprotein transport
M0016192biological_processvesicle-mediated transport
M0030121cellular_componentAP-1 adaptor complex
M0030131cellular_componentclathrin adaptor complex
M0030665cellular_componentclathrin-coated vesicle membrane
M0031410cellular_componentcytoplasmic vesicle
M0032438biological_processmelanosome organization
M0032588cellular_componenttrans-Golgi network membrane
M0035615molecular_functionclathrin adaptor activity
M0035646biological_processendosome to melanosome transport
M0045202cellular_componentsynapse
M0060155biological_processplatelet dense granule organization
M1903232biological_processmelanosome assembly
N0005102molecular_functionsignaling receptor binding
N0005515molecular_functionprotein binding
N0005525molecular_functionGTP binding
N0005576cellular_componentextracellular region
N0010561biological_processnegative regulation of glycoprotein biosynthetic process
N0016020cellular_componentmembrane
N0017124molecular_functionSH3 domain binding
N0019058biological_processviral life cycle
N0019901molecular_functionprotein kinase binding
N0020002cellular_componenthost cell plasma membrane
N0031996molecular_functionthioesterase binding
N0033668biological_processsymbiont-mediated suppression of host apoptosis
N0039504biological_processsymbiont-mediated suppression of host adaptive immune response
N0039505biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
N0042288molecular_functionMHC class I protein binding
N0042609molecular_functionCD4 receptor binding
N0044178cellular_componenthost cell Golgi membrane
N0044423cellular_componentvirion component
N0046776biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
N0050848biological_processregulation of calcium-mediated signaling
N0051117molecular_functionATPase binding
N0051246biological_processregulation of protein metabolic process
N0051701biological_processbiological process involved in interaction with host
N0052031biological_processsymbiont-mediated perturbation of host defense response
N0052170biological_processsymbiont-mediated suppression of host innate immune response
N0070206biological_processprotein trimerization
N0140321biological_processsymbiont-mediated suppression of host autophagy
O0006886biological_processintracellular protein transport
O0016192biological_processvesicle-mediated transport
O0030117cellular_componentmembrane coat
U0005102molecular_functionsignaling receptor binding
U0005515molecular_functionprotein binding
U0005525molecular_functionGTP binding
U0005576cellular_componentextracellular region
U0010561biological_processnegative regulation of glycoprotein biosynthetic process
U0016020cellular_componentmembrane
U0017124molecular_functionSH3 domain binding
U0019058biological_processviral life cycle
U0019901molecular_functionprotein kinase binding
U0020002cellular_componenthost cell plasma membrane
U0031996molecular_functionthioesterase binding
U0033668biological_processsymbiont-mediated suppression of host apoptosis
U0039504biological_processsymbiont-mediated suppression of host adaptive immune response
U0039505biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
U0042288molecular_functionMHC class I protein binding
U0042609molecular_functionCD4 receptor binding
U0044178cellular_componenthost cell Golgi membrane
U0044423cellular_componentvirion component
U0046776biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
U0050848biological_processregulation of calcium-mediated signaling
U0051117molecular_functionATPase binding
U0051246biological_processregulation of protein metabolic process
U0051701biological_processbiological process involved in interaction with host
U0052031biological_processsymbiont-mediated perturbation of host defense response
U0052170biological_processsymbiont-mediated suppression of host innate immune response
U0070206biological_processprotein trimerization
U0140321biological_processsymbiont-mediated suppression of host autophagy
V0005102molecular_functionsignaling receptor binding
V0005515molecular_functionprotein binding
V0005525molecular_functionGTP binding
V0005576cellular_componentextracellular region
V0010561biological_processnegative regulation of glycoprotein biosynthetic process
V0016020cellular_componentmembrane
V0017124molecular_functionSH3 domain binding
V0019058biological_processviral life cycle
V0019901molecular_functionprotein kinase binding
V0020002cellular_componenthost cell plasma membrane
V0031996molecular_functionthioesterase binding
V0033668biological_processsymbiont-mediated suppression of host apoptosis
V0039504biological_processsymbiont-mediated suppression of host adaptive immune response
V0039505biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class II
V0042288molecular_functionMHC class I protein binding
V0042609molecular_functionCD4 receptor binding
V0044178cellular_componenthost cell Golgi membrane
V0044423cellular_componentvirion component
V0046776biological_processsymbiont-mediated suppression of host antigen processing and presentation of peptide antigen via MHC class I
V0050848biological_processregulation of calcium-mediated signaling
V0051117molecular_functionATPase binding
V0051246biological_processregulation of protein metabolic process
V0051701biological_processbiological process involved in interaction with host
V0052031biological_processsymbiont-mediated perturbation of host defense response
V0052170biological_processsymbiont-mediated suppression of host innate immune response
V0070206biological_processprotein trimerization
V0140321biological_processsymbiont-mediated suppression of host autophagy
X0005515molecular_functionprotein binding
X0005765cellular_componentlysosomal membrane
X0005769cellular_componentearly endosome
X0005794cellular_componentGolgi apparatus
X0005802cellular_componenttrans-Golgi network
X0005829cellular_componentcytosol
X0006886biological_processintracellular protein transport
X0006896biological_processGolgi to vacuole transport
X0015031biological_processprotein transport
X0016192biological_processvesicle-mediated transport
X0030121cellular_componentAP-1 adaptor complex
X0030131cellular_componentclathrin adaptor complex
X0030665cellular_componentclathrin-coated vesicle membrane
X0031410cellular_componentcytoplasmic vesicle
X0032438biological_processmelanosome organization
X0032588cellular_componenttrans-Golgi network membrane
X0035615molecular_functionclathrin adaptor activity
X0035646biological_processendosome to melanosome transport
X0045202cellular_componentsynapse
X0060155biological_processplatelet dense granule organization
X1903232biological_processmelanosome assembly
Y0006955biological_processimmune response
Y0019882biological_processantigen processing and presentation
Z0005515molecular_functionprotein binding
Z0005765cellular_componentlysosomal membrane
Z0005769cellular_componentearly endosome
Z0005794cellular_componentGolgi apparatus
Z0005802cellular_componenttrans-Golgi network
Z0005829cellular_componentcytosol
Z0006886biological_processintracellular protein transport
Z0006896biological_processGolgi to vacuole transport
Z0015031biological_processprotein transport
Z0016192biological_processvesicle-mediated transport
Z0030121cellular_componentAP-1 adaptor complex
Z0030131cellular_componentclathrin adaptor complex
Z0030665cellular_componentclathrin-coated vesicle membrane
Z0031410cellular_componentcytoplasmic vesicle
Z0032438biological_processmelanosome organization
Z0032588cellular_componenttrans-Golgi network membrane
Z0035615molecular_functionclathrin adaptor activity
Z0035646biological_processendosome to melanosome transport
Z0045202cellular_componentsynapse
Z0060155biological_processplatelet dense granule organization
Z1903232biological_processmelanosome assembly
Functional Information from PROSITE/UniProt
site_idPS00989
Number of Residues11
DetailsCLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. LVYKryasLYF
ChainResidueDetails
eLEU57-PHE67

site_idPS00990
Number of Residues21
DetailsCLAT_ADAPTOR_M_1 Clathrin adaptor complexes medium chain signature 1. VSWRse.GikYrkNeVFLDVIE
ChainResidueDetails
MVAL157-GLU177

site_idPS00991
Number of Residues15
DetailsCLAT_ADAPTOR_M_2 Clathrin adaptor complexes medium chain signature 2. IsFIPPdGeFeLmsY
ChainResidueDetails
MILE253-TYR267

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI7
Number of Residues8
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues4
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"UniProtKB","id":"Q9BXS5","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues8
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17242355","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q32Q06","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues26
DetailsRegion: {"description":"Important for the stable binding to the membranes","evidences":[{"source":"UniProtKB","id":"P84080","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"7990966","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HUR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"14690595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15308674","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7990966","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of ARFGAP1-ARF1 fusion protein.","authoringGroup":["Structural genomics consortium (SGC)."]}},{"source":"PDB","id":"1HUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1U81","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3O47","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"15308674","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7990966","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2010","submissionDatabase":"PDB data bank","title":"Crystal structure of ARFGAP1-ARF1 fusion protein.","authoringGroup":["Structural genomics consortium (SGC)."]}},{"source":"PDB","id":"1HUR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3O47","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues2
DetailsModified residue: {"description":"N-acetylglycine; alternate","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI18
Number of Residues2
DetailsLipidation: {"description":"N-myristoyl glycine; alternate","evidences":[{"source":"PubMed","id":"20213681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23535599","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25255805","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25807930","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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