8D9K

CryoEM structure of human METTL1-WDR4 in complex with Lys-tRNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005730	cellular_component	nucleolus
A	0005829	cellular_component	cytosol
A	0006400	biological_process	tRNA modification
A	0008033	biological_process	tRNA processing
A	0008168	molecular_function	methyltransferase activity
A	0008176	molecular_function	tRNA (guanine(46)-N7)-methyltransferase activity
A	0030488	biological_process	tRNA methylation
A	0032259	biological_process	methylation
A	0033554	biological_process	cellular response to stress
A	0036265	biological_process	RNA (guanine-N7)-methylation
A	0036416	biological_process	tRNA stabilization
A	0043527	cellular_component	tRNA methyltransferase complex
A	0106004	biological_process	tRNA (guanine-N7)-methylation
A	0106143	cellular_component	tRNA (m7G46) methyltransferase complex
A	0160090	molecular_function	internal mRNA (guanine-N7-)-methyltransferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005694	cellular_component	chromosome
B	0005829	cellular_component	cytosol
B	0006400	biological_process	tRNA modification
B	0006974	biological_process	DNA damage response
B	0008033	biological_process	tRNA processing
B	0008047	molecular_function	enzyme activator activity
B	0030488	biological_process	tRNA methylation
B	0036265	biological_process	RNA (guanine-N7)-methylation
B	0043527	cellular_component	tRNA methyltransferase complex
B	0106004	biological_process	tRNA (guanine-N7)-methylation
B	0106143	cellular_component	tRNA (m7G46) methyltransferase complex
B	0141106	molecular_function	tRNA methyltransferase activator activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:36599982, ECO:0000305|PubMed:36599985

Chain	Residue	Details
A	ASP163

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:36599982, ECO:0000269|Ref.19, ECO:0007744|PDB:3CKK, ECO:0007744|PDB:8D9L

Chain	Residue	Details
A	GLY84
A	GLU107
A	ASN140
A	THR238

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:36599985, ECO:0007744|PDB:8CTH

Chain	Residue	Details
A	ILE108

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|Ref.19, ECO:0007744|PDB:3CKK

Chain	Residue	Details
A	ARG109
A	ALA141
A	LEU160
A	GLU240

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	ALA2

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKB/AKT1 and RPS6KA3 => ECO:0000269|PubMed:15861136, ECO:0000269|PubMed:36599985, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER27

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