Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8D9J

SAMHD1-DNA complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000724biological_processdouble-strand break repair via homologous recombination
A0002376biological_processimmune system process
A0003676molecular_functionnucleic acid binding
A0003697molecular_functionsingle-stranded DNA binding
A0003723molecular_functionRNA binding
A0003824molecular_functioncatalytic activity
A0004540molecular_functionRNA nuclease activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005694cellular_componentchromosome
A0005886cellular_componentplasma membrane
A0006203biological_processdGTP catabolic process
A0006260biological_processDNA replication
A0006281biological_processDNA repair
A0006955biological_processimmune response
A0006974biological_processDNA damage response
A0008270molecular_functionzinc ion binding
A0008832molecular_functiondGTPase activity
A0009264biological_processdeoxyribonucleotide catabolic process
A0016446biological_processsomatic hypermutation of immunoglobulin genes
A0016787molecular_functionhydrolase activity
A0016793molecular_functiontriphosphoric monoester hydrolase activity
A0032567molecular_functiondGTP binding
A0035861cellular_componentsite of double-strand break
A0042802molecular_functionidentical protein binding
A0045087biological_processinnate immune response
A0045088biological_processregulation of innate immune response
A0046061biological_processdATP catabolic process
A0046872molecular_functionmetal ion binding
A0051289biological_processprotein homotetramerization
A0051607biological_processdefense response to virus
A0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
A0097197cellular_componenttetraspanin-enriched microdomain
A0106375molecular_functiondeoxynucleoside triphosphate hydrolase activity
A0110025biological_processDNA strand resection involved in replication fork processing
B0000166molecular_functionnucleotide binding
B0000724biological_processdouble-strand break repair via homologous recombination
B0002376biological_processimmune system process
B0003676molecular_functionnucleic acid binding
B0003697molecular_functionsingle-stranded DNA binding
B0003723molecular_functionRNA binding
B0003824molecular_functioncatalytic activity
B0004540molecular_functionRNA nuclease activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005694cellular_componentchromosome
B0005886cellular_componentplasma membrane
B0006203biological_processdGTP catabolic process
B0006260biological_processDNA replication
B0006281biological_processDNA repair
B0006955biological_processimmune response
B0006974biological_processDNA damage response
B0008270molecular_functionzinc ion binding
B0008832molecular_functiondGTPase activity
B0009264biological_processdeoxyribonucleotide catabolic process
B0016446biological_processsomatic hypermutation of immunoglobulin genes
B0016787molecular_functionhydrolase activity
B0016793molecular_functiontriphosphoric monoester hydrolase activity
B0032567molecular_functiondGTP binding
B0035861cellular_componentsite of double-strand break
B0042802molecular_functionidentical protein binding
B0045087biological_processinnate immune response
B0045088biological_processregulation of innate immune response
B0046061biological_processdATP catabolic process
B0046872molecular_functionmetal ion binding
B0051289biological_processprotein homotetramerization
B0051607biological_processdefense response to virus
B0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
B0097197cellular_componenttetraspanin-enriched microdomain
B0106375molecular_functiondeoxynucleoside triphosphate hydrolase activity
B0110025biological_processDNA strand resection involved in replication fork processing
C0000166molecular_functionnucleotide binding
C0000724biological_processdouble-strand break repair via homologous recombination
C0002376biological_processimmune system process
C0003676molecular_functionnucleic acid binding
C0003697molecular_functionsingle-stranded DNA binding
C0003723molecular_functionRNA binding
C0003824molecular_functioncatalytic activity
C0004540molecular_functionRNA nuclease activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005694cellular_componentchromosome
C0005886cellular_componentplasma membrane
C0006203biological_processdGTP catabolic process
C0006260biological_processDNA replication
C0006281biological_processDNA repair
C0006955biological_processimmune response
C0006974biological_processDNA damage response
C0008270molecular_functionzinc ion binding
C0008832molecular_functiondGTPase activity
C0009264biological_processdeoxyribonucleotide catabolic process
C0016446biological_processsomatic hypermutation of immunoglobulin genes
C0016787molecular_functionhydrolase activity
C0016793molecular_functiontriphosphoric monoester hydrolase activity
C0032567molecular_functiondGTP binding
C0035861cellular_componentsite of double-strand break
C0042802molecular_functionidentical protein binding
C0045087biological_processinnate immune response
C0045088biological_processregulation of innate immune response
C0046061biological_processdATP catabolic process
C0046872molecular_functionmetal ion binding
C0051289biological_processprotein homotetramerization
C0051607biological_processdefense response to virus
C0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
C0097197cellular_componenttetraspanin-enriched microdomain
C0106375molecular_functiondeoxynucleoside triphosphate hydrolase activity
C0110025biological_processDNA strand resection involved in replication fork processing
D0000166molecular_functionnucleotide binding
D0000724biological_processdouble-strand break repair via homologous recombination
D0002376biological_processimmune system process
D0003676molecular_functionnucleic acid binding
D0003697molecular_functionsingle-stranded DNA binding
D0003723molecular_functionRNA binding
D0003824molecular_functioncatalytic activity
D0004540molecular_functionRNA nuclease activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005694cellular_componentchromosome
D0005886cellular_componentplasma membrane
D0006203biological_processdGTP catabolic process
D0006260biological_processDNA replication
D0006281biological_processDNA repair
D0006955biological_processimmune response
D0006974biological_processDNA damage response
D0008270molecular_functionzinc ion binding
D0008832molecular_functiondGTPase activity
D0009264biological_processdeoxyribonucleotide catabolic process
D0016446biological_processsomatic hypermutation of immunoglobulin genes
D0016787molecular_functionhydrolase activity
D0016793molecular_functiontriphosphoric monoester hydrolase activity
D0032567molecular_functiondGTP binding
D0035861cellular_componentsite of double-strand break
D0042802molecular_functionidentical protein binding
D0045087biological_processinnate immune response
D0045088biological_processregulation of innate immune response
D0046061biological_processdATP catabolic process
D0046872molecular_functionmetal ion binding
D0051289biological_processprotein homotetramerization
D0051607biological_processdefense response to virus
D0060339biological_processnegative regulation of type I interferon-mediated signaling pathway
D0097197cellular_componenttetraspanin-enriched microdomain
D0106375molecular_functiondeoxynucleoside triphosphate hydrolase activity
D0110025biological_processDNA strand resection involved in replication fork processing
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"evidences":[{"source":"PubMed","id":"22056990","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues20
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues32
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"24141705","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BZB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues16
DetailsBinding site: {"description":"in chain C","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"24141705","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4BZB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues8
DetailsBinding site: {"description":"in chain C","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsBinding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"25267621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4TNP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TNX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues16
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

PDB statisticsPDBj update infoContact PDBjnumon