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8D8O

Cryo-EM structure of substrate unbound PAPP-A

Functional Information from GO Data
ChainGOidnamespacecontents
A0004175molecular_functionendopeptidase activity
A0004222molecular_functionmetalloendopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0007166biological_processcell surface receptor signaling pathway
A0007565biological_processfemale pregnancy
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0030163biological_processprotein catabolic process
A0032354biological_processresponse to follicle-stimulating hormone
A0046872molecular_functionmetal ion binding
A0071548biological_processresponse to dexamethasone
B0004175molecular_functionendopeptidase activity
B0004222molecular_functionmetalloendopeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006508biological_processproteolysis
B0007166biological_processcell surface receptor signaling pathway
B0007565biological_processfemale pregnancy
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0030163biological_processprotein catabolic process
B0032354biological_processresponse to follicle-stimulating hormone
B0046872molecular_functionmetal ion binding
B0071548biological_processresponse to dexamethasone
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095
ChainResidueDetails
AALA483
BALA483

site_idSWS_FT_FI2
Number of Residues6
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU10095
ChainResidueDetails
AHIS482
AHIS486
AHIS492
BHIS482
BHIS486
BHIS492

site_idSWS_FT_FI3
Number of Residues8
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN310
AASN745
AASN1142
AASN1385
BASN310
BASN745
BASN1142
BASN1385

site_idSWS_FT_FI4
Number of Residues20
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12421832
ChainResidueDetails
AASN322
AASN1439
BASN322
BASN349
BASN400
BASN521
BASN539
BASN645
BASN946
BASN1146
BASN1243
AASN349
BASN1439
AASN400
AASN521
AASN539
AASN645
AASN946
AASN1146
AASN1243

224572

PDB entries from 2024-09-04

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