8D7R

Cryo-EM structure of human CLCF1 signaling complex: model containing the interaction core region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004896	molecular_function	cytokine receptor activity
A	0016020	cellular_component	membrane
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane
C	0001967	biological_process	suckling behavior
C	0003360	biological_process	brainstem development
C	0004896	molecular_function	cytokine receptor activity
C	0004897	molecular_function	ciliary neurotrophic factor receptor activity
C	0005102	molecular_function	signaling receptor binding
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0007165	biological_process	signal transduction
C	0007399	biological_process	nervous system development
C	0007548	biological_process	sex differentiation
C	0008284	biological_process	positive regulation of cell population proliferation
C	0009897	cellular_component	external side of plasma membrane
C	0016020	cellular_component	membrane
C	0016324	cellular_component	apical plasma membrane
C	0019898	cellular_component	extrinsic component of membrane
C	0019955	molecular_function	cytokine binding
C	0043524	biological_process	negative regulation of neuron apoptotic process
C	0060538	biological_process	skeletal muscle organ development
C	0070110	cellular_component	ciliary neurotrophic factor receptor complex
C	0070120	biological_process	ciliary neurotrophic factor-mediated signaling pathway
C	0097049	biological_process	motor neuron apoptotic process
C	0097059	cellular_component	CNTFR-CLCF1 complex
C	0098552	cellular_component	side of membrane
C	2000672	biological_process	negative regulation of motor neuron apoptotic process
D	0002639	biological_process	positive regulation of immunoglobulin production
D	0005102	molecular_function	signaling receptor binding
D	0005125	molecular_function	cytokine activity
D	0005127	molecular_function	ciliary neurotrophic factor receptor binding
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0007166	biological_process	cell surface receptor signaling pathway
D	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
D	0008083	molecular_function	growth factor activity
D	0008284	biological_process	positive regulation of cell population proliferation
D	0019221	biological_process	cytokine-mediated signaling pathway
D	0030183	biological_process	B cell differentiation
D	0030890	biological_process	positive regulation of B cell proliferation
D	0043524	biological_process	negative regulation of neuron apoptotic process
D	0048295	biological_process	positive regulation of isotype switching to IgE isotypes
D	0048711	biological_process	positive regulation of astrocyte differentiation
D	0097058	cellular_component	CRLF-CLCF1 complex
D	0097059	cellular_component	CNTFR-CLCF1 complex
D	0097696	biological_process	cell surface receptor signaling pathway via STAT

Functional Information from PROSITE/UniProt

site_id	PS01353
Number of Residues	51
Details	HEMATOPO_REC_L_F2 Long hematopoietin receptor, gp130 family signature. NsvgsSppskiasmeipnddlkieqvvgmgkgil.......LtWhydPnmtcd....Yv.IkW

Chain	Residue	Details
B	ASN611-TRP661
A	ASN404-TRP457

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site_id	PS01354
Number of Residues	43
Details	HEMATOPO_REC_L_F3 Long hematopoietin receptor, soluble alpha chains family signature. VkPDPPenVvarpvpsnprrLevtWqtPsTWpdpes.FpLkFfL

Chain	Residue	Details
C	VAL202-LEU244

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	596
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
A	GLU23-GLU619

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site_id	SWS_FT_FI2
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:20489211

Chain	Residue	Details
A	ASN43
B	ASN572
B	ASN652
B	ASN663
B	ASN680
B	ASN729
B	ASN787
A	ASN83
A	ASN553
B	ASN191
B	ASN243
B	ASN390
B	ASN445
B	ASN481
B	ASN489

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site_id	SWS_FT_FI3
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061

Chain	Residue	Details
A	ASN131
A	ASN157
A	ASN564
B	ASN426

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20489211

Chain	Residue	Details
A	ASN227

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:16335952

Chain	Residue	Details
A	ASN379

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11098061, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:20489211

Chain	Residue	Details
A	ASN383

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site_id	SWS_FT_FI7
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN390

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