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8D6W

Structure of the Mycobacterium tuberculosis 20S proteasome bound to the C-terminal GQYL motif of the ADP-bound Mpa ATPase

Functional Information from GO Data
ChainGOidnamespacecontents
a0000502cellular_componentproteasome complex
a0004175molecular_functionendopeptidase activity
a0004298molecular_functionthreonine-type endopeptidase activity
a0005515molecular_functionprotein binding
a0005576cellular_componentextracellular region
a0005737cellular_componentcytoplasm
a0005839cellular_componentproteasome core complex
a0005886cellular_componentplasma membrane
a0006508biological_processproteolysis
a0010498biological_processproteasomal protein catabolic process
a0019774cellular_componentproteasome core complex, beta-subunit complex
a0019941biological_processmodification-dependent protein catabolic process
a0030682biological_processsymbiont-mediated perturbation of host defenses
a0035375molecular_functionzymogen binding
a0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
a0051603biological_processproteolysis involved in protein catabolic process
A0000502cellular_componentproteasome complex
A0004175molecular_functionendopeptidase activity
A0004298molecular_functionthreonine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005839cellular_componentproteasome core complex
A0005886cellular_componentplasma membrane
A0009274cellular_componentpeptidoglycan-based cell wall
A0010498biological_processproteasomal protein catabolic process
A0019773cellular_componentproteasome core complex, alpha-subunit complex
A0019941biological_processmodification-dependent protein catabolic process
A0030682biological_processsymbiont-mediated perturbation of host defenses
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0051603biological_processproteolysis involved in protein catabolic process
b0000502cellular_componentproteasome complex
b0004175molecular_functionendopeptidase activity
b0004298molecular_functionthreonine-type endopeptidase activity
b0005515molecular_functionprotein binding
b0005576cellular_componentextracellular region
b0005737cellular_componentcytoplasm
b0005839cellular_componentproteasome core complex
b0005886cellular_componentplasma membrane
b0006508biological_processproteolysis
b0010498biological_processproteasomal protein catabolic process
b0019774cellular_componentproteasome core complex, beta-subunit complex
b0019941biological_processmodification-dependent protein catabolic process
b0030682biological_processsymbiont-mediated perturbation of host defenses
b0035375molecular_functionzymogen binding
b0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
b0051603biological_processproteolysis involved in protein catabolic process
c0000502cellular_componentproteasome complex
c0004175molecular_functionendopeptidase activity
c0004298molecular_functionthreonine-type endopeptidase activity
c0005515molecular_functionprotein binding
c0005576cellular_componentextracellular region
c0005737cellular_componentcytoplasm
c0005839cellular_componentproteasome core complex
c0005886cellular_componentplasma membrane
c0006508biological_processproteolysis
c0010498biological_processproteasomal protein catabolic process
c0019774cellular_componentproteasome core complex, beta-subunit complex
c0019941biological_processmodification-dependent protein catabolic process
c0030682biological_processsymbiont-mediated perturbation of host defenses
c0035375molecular_functionzymogen binding
c0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
c0051603biological_processproteolysis involved in protein catabolic process
C0000502cellular_componentproteasome complex
C0004175molecular_functionendopeptidase activity
C0004298molecular_functionthreonine-type endopeptidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005839cellular_componentproteasome core complex
C0005886cellular_componentplasma membrane
C0009274cellular_componentpeptidoglycan-based cell wall
C0010498biological_processproteasomal protein catabolic process
C0019773cellular_componentproteasome core complex, alpha-subunit complex
C0019941biological_processmodification-dependent protein catabolic process
C0030682biological_processsymbiont-mediated perturbation of host defenses
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0051603biological_processproteolysis involved in protein catabolic process
D0000502cellular_componentproteasome complex
D0004175molecular_functionendopeptidase activity
D0004298molecular_functionthreonine-type endopeptidase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005839cellular_componentproteasome core complex
D0005886cellular_componentplasma membrane
D0009274cellular_componentpeptidoglycan-based cell wall
D0010498biological_processproteasomal protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0019941biological_processmodification-dependent protein catabolic process
D0030682biological_processsymbiont-mediated perturbation of host defenses
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0051603biological_processproteolysis involved in protein catabolic process
E0000502cellular_componentproteasome complex
E0004175molecular_functionendopeptidase activity
E0004298molecular_functionthreonine-type endopeptidase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005839cellular_componentproteasome core complex
E0005886cellular_componentplasma membrane
E0009274cellular_componentpeptidoglycan-based cell wall
E0010498biological_processproteasomal protein catabolic process
E0019773cellular_componentproteasome core complex, alpha-subunit complex
E0019941biological_processmodification-dependent protein catabolic process
E0030682biological_processsymbiont-mediated perturbation of host defenses
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0051603biological_processproteolysis involved in protein catabolic process
F0000502cellular_componentproteasome complex
F0004175molecular_functionendopeptidase activity
F0004298molecular_functionthreonine-type endopeptidase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005839cellular_componentproteasome core complex
F0005886cellular_componentplasma membrane
F0009274cellular_componentpeptidoglycan-based cell wall
F0010498biological_processproteasomal protein catabolic process
F0019773cellular_componentproteasome core complex, alpha-subunit complex
F0019941biological_processmodification-dependent protein catabolic process
F0030682biological_processsymbiont-mediated perturbation of host defenses
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0051603biological_processproteolysis involved in protein catabolic process
G0000502cellular_componentproteasome complex
G0004175molecular_functionendopeptidase activity
G0004298molecular_functionthreonine-type endopeptidase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005839cellular_componentproteasome core complex
G0005886cellular_componentplasma membrane
G0009274cellular_componentpeptidoglycan-based cell wall
G0010498biological_processproteasomal protein catabolic process
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0019941biological_processmodification-dependent protein catabolic process
G0030682biological_processsymbiont-mediated perturbation of host defenses
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0051603biological_processproteolysis involved in protein catabolic process
H0000502cellular_componentproteasome complex
H0004175molecular_functionendopeptidase activity
H0004298molecular_functionthreonine-type endopeptidase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005839cellular_componentproteasome core complex
H0005886cellular_componentplasma membrane
H0009274cellular_componentpeptidoglycan-based cell wall
H0010498biological_processproteasomal protein catabolic process
H0019773cellular_componentproteasome core complex, alpha-subunit complex
H0019941biological_processmodification-dependent protein catabolic process
H0030682biological_processsymbiont-mediated perturbation of host defenses
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0051603biological_processproteolysis involved in protein catabolic process
I0000502cellular_componentproteasome complex
I0004175molecular_functionendopeptidase activity
I0004298molecular_functionthreonine-type endopeptidase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005839cellular_componentproteasome core complex
I0005886cellular_componentplasma membrane
I0009274cellular_componentpeptidoglycan-based cell wall
I0010498biological_processproteasomal protein catabolic process
I0019773cellular_componentproteasome core complex, alpha-subunit complex
I0019941biological_processmodification-dependent protein catabolic process
I0030682biological_processsymbiont-mediated perturbation of host defenses
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0051603biological_processproteolysis involved in protein catabolic process
J0000502cellular_componentproteasome complex
J0004175molecular_functionendopeptidase activity
J0004298molecular_functionthreonine-type endopeptidase activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005839cellular_componentproteasome core complex
J0005886cellular_componentplasma membrane
J0009274cellular_componentpeptidoglycan-based cell wall
J0010498biological_processproteasomal protein catabolic process
J0019773cellular_componentproteasome core complex, alpha-subunit complex
J0019941biological_processmodification-dependent protein catabolic process
J0030682biological_processsymbiont-mediated perturbation of host defenses
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0051603biological_processproteolysis involved in protein catabolic process
K0000502cellular_componentproteasome complex
K0004175molecular_functionendopeptidase activity
K0004298molecular_functionthreonine-type endopeptidase activity
K0005515molecular_functionprotein binding
K0005737cellular_componentcytoplasm
K0005839cellular_componentproteasome core complex
K0005886cellular_componentplasma membrane
K0009274cellular_componentpeptidoglycan-based cell wall
K0010498biological_processproteasomal protein catabolic process
K0019773cellular_componentproteasome core complex, alpha-subunit complex
K0019941biological_processmodification-dependent protein catabolic process
K0030682biological_processsymbiont-mediated perturbation of host defenses
K0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K0051603biological_processproteolysis involved in protein catabolic process
L0000502cellular_componentproteasome complex
L0004175molecular_functionendopeptidase activity
L0004298molecular_functionthreonine-type endopeptidase activity
L0005515molecular_functionprotein binding
L0005737cellular_componentcytoplasm
L0005839cellular_componentproteasome core complex
L0005886cellular_componentplasma membrane
L0009274cellular_componentpeptidoglycan-based cell wall
L0010498biological_processproteasomal protein catabolic process
L0019773cellular_componentproteasome core complex, alpha-subunit complex
L0019941biological_processmodification-dependent protein catabolic process
L0030682biological_processsymbiont-mediated perturbation of host defenses
L0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
L0051603biological_processproteolysis involved in protein catabolic process
M0000502cellular_componentproteasome complex
M0004175molecular_functionendopeptidase activity
M0004298molecular_functionthreonine-type endopeptidase activity
M0005515molecular_functionprotein binding
M0005737cellular_componentcytoplasm
M0005839cellular_componentproteasome core complex
M0005886cellular_componentplasma membrane
M0009274cellular_componentpeptidoglycan-based cell wall
M0010498biological_processproteasomal protein catabolic process
M0019773cellular_componentproteasome core complex, alpha-subunit complex
M0019941biological_processmodification-dependent protein catabolic process
M0030682biological_processsymbiont-mediated perturbation of host defenses
M0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
M0051603biological_processproteolysis involved in protein catabolic process
N0000502cellular_componentproteasome complex
N0004175molecular_functionendopeptidase activity
N0004298molecular_functionthreonine-type endopeptidase activity
N0005515molecular_functionprotein binding
N0005737cellular_componentcytoplasm
N0005839cellular_componentproteasome core complex
N0005886cellular_componentplasma membrane
N0009274cellular_componentpeptidoglycan-based cell wall
N0010498biological_processproteasomal protein catabolic process
N0019773cellular_componentproteasome core complex, alpha-subunit complex
N0019941biological_processmodification-dependent protein catabolic process
N0030682biological_processsymbiont-mediated perturbation of host defenses
N0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
N0051603biological_processproteolysis involved in protein catabolic process
O0000502cellular_componentproteasome complex
O0004175molecular_functionendopeptidase activity
O0004298molecular_functionthreonine-type endopeptidase activity
O0005515molecular_functionprotein binding
O0005737cellular_componentcytoplasm
O0005839cellular_componentproteasome core complex
O0005886cellular_componentplasma membrane
O0009274cellular_componentpeptidoglycan-based cell wall
O0010498biological_processproteasomal protein catabolic process
O0019773cellular_componentproteasome core complex, alpha-subunit complex
O0019941biological_processmodification-dependent protein catabolic process
O0030682biological_processsymbiont-mediated perturbation of host defenses
O0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
O0051603biological_processproteolysis involved in protein catabolic process
P0000502cellular_componentproteasome complex
P0004175molecular_functionendopeptidase activity
P0004298molecular_functionthreonine-type endopeptidase activity
P0005515molecular_functionprotein binding
P0005576cellular_componentextracellular region
P0005737cellular_componentcytoplasm
P0005839cellular_componentproteasome core complex
P0005886cellular_componentplasma membrane
P0006508biological_processproteolysis
P0010498biological_processproteasomal protein catabolic process
P0019774cellular_componentproteasome core complex, beta-subunit complex
P0019941biological_processmodification-dependent protein catabolic process
P0030682biological_processsymbiont-mediated perturbation of host defenses
P0035375molecular_functionzymogen binding
P0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
P0051603biological_processproteolysis involved in protein catabolic process
Q0000502cellular_componentproteasome complex
Q0004175molecular_functionendopeptidase activity
Q0004298molecular_functionthreonine-type endopeptidase activity
Q0005515molecular_functionprotein binding
Q0005576cellular_componentextracellular region
Q0005737cellular_componentcytoplasm
Q0005839cellular_componentproteasome core complex
Q0005886cellular_componentplasma membrane
Q0006508biological_processproteolysis
Q0010498biological_processproteasomal protein catabolic process
Q0019774cellular_componentproteasome core complex, beta-subunit complex
Q0019941biological_processmodification-dependent protein catabolic process
Q0030682biological_processsymbiont-mediated perturbation of host defenses
Q0035375molecular_functionzymogen binding
Q0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Q0051603biological_processproteolysis involved in protein catabolic process
R0000502cellular_componentproteasome complex
R0004175molecular_functionendopeptidase activity
R0004298molecular_functionthreonine-type endopeptidase activity
R0005515molecular_functionprotein binding
R0005576cellular_componentextracellular region
R0005737cellular_componentcytoplasm
R0005839cellular_componentproteasome core complex
R0005886cellular_componentplasma membrane
R0006508biological_processproteolysis
R0010498biological_processproteasomal protein catabolic process
R0019774cellular_componentproteasome core complex, beta-subunit complex
R0019941biological_processmodification-dependent protein catabolic process
R0030682biological_processsymbiont-mediated perturbation of host defenses
R0035375molecular_functionzymogen binding
R0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
R0051603biological_processproteolysis involved in protein catabolic process
S0000502cellular_componentproteasome complex
S0004175molecular_functionendopeptidase activity
S0004298molecular_functionthreonine-type endopeptidase activity
S0005515molecular_functionprotein binding
S0005576cellular_componentextracellular region
S0005737cellular_componentcytoplasm
S0005839cellular_componentproteasome core complex
S0005886cellular_componentplasma membrane
S0006508biological_processproteolysis
S0010498biological_processproteasomal protein catabolic process
S0019774cellular_componentproteasome core complex, beta-subunit complex
S0019941biological_processmodification-dependent protein catabolic process
S0030682biological_processsymbiont-mediated perturbation of host defenses
S0035375molecular_functionzymogen binding
S0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
S0051603biological_processproteolysis involved in protein catabolic process
T0000502cellular_componentproteasome complex
T0004175molecular_functionendopeptidase activity
T0004298molecular_functionthreonine-type endopeptidase activity
T0005515molecular_functionprotein binding
T0005576cellular_componentextracellular region
T0005737cellular_componentcytoplasm
T0005839cellular_componentproteasome core complex
T0005886cellular_componentplasma membrane
T0006508biological_processproteolysis
T0010498biological_processproteasomal protein catabolic process
T0019774cellular_componentproteasome core complex, beta-subunit complex
T0019941biological_processmodification-dependent protein catabolic process
T0030682biological_processsymbiont-mediated perturbation of host defenses
T0035375molecular_functionzymogen binding
T0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
T0051603biological_processproteolysis involved in protein catabolic process
U0000502cellular_componentproteasome complex
U0004175molecular_functionendopeptidase activity
U0004298molecular_functionthreonine-type endopeptidase activity
U0005515molecular_functionprotein binding
U0005576cellular_componentextracellular region
U0005737cellular_componentcytoplasm
U0005839cellular_componentproteasome core complex
U0005886cellular_componentplasma membrane
U0006508biological_processproteolysis
U0010498biological_processproteasomal protein catabolic process
U0019774cellular_componentproteasome core complex, beta-subunit complex
U0019941biological_processmodification-dependent protein catabolic process
U0030682biological_processsymbiont-mediated perturbation of host defenses
U0035375molecular_functionzymogen binding
U0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
U0051603biological_processproteolysis involved in protein catabolic process
V0000502cellular_componentproteasome complex
V0004175molecular_functionendopeptidase activity
V0004298molecular_functionthreonine-type endopeptidase activity
V0005515molecular_functionprotein binding
V0005576cellular_componentextracellular region
V0005737cellular_componentcytoplasm
V0005839cellular_componentproteasome core complex
V0005886cellular_componentplasma membrane
V0006508biological_processproteolysis
V0010498biological_processproteasomal protein catabolic process
V0019774cellular_componentproteasome core complex, beta-subunit complex
V0019941biological_processmodification-dependent protein catabolic process
V0030682biological_processsymbiont-mediated perturbation of host defenses
V0035375molecular_functionzymogen binding
V0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
V0051603biological_processproteolysis involved in protein catabolic process
W0000502cellular_componentproteasome complex
W0004175molecular_functionendopeptidase activity
W0004298molecular_functionthreonine-type endopeptidase activity
W0005515molecular_functionprotein binding
W0005576cellular_componentextracellular region
W0005737cellular_componentcytoplasm
W0005839cellular_componentproteasome core complex
W0005886cellular_componentplasma membrane
W0006508biological_processproteolysis
W0010498biological_processproteasomal protein catabolic process
W0019774cellular_componentproteasome core complex, beta-subunit complex
W0019941biological_processmodification-dependent protein catabolic process
W0030682biological_processsymbiont-mediated perturbation of host defenses
W0035375molecular_functionzymogen binding
W0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
W0051603biological_processproteolysis involved in protein catabolic process
X0000502cellular_componentproteasome complex
X0004175molecular_functionendopeptidase activity
X0004298molecular_functionthreonine-type endopeptidase activity
X0005515molecular_functionprotein binding
X0005576cellular_componentextracellular region
X0005737cellular_componentcytoplasm
X0005839cellular_componentproteasome core complex
X0005886cellular_componentplasma membrane
X0006508biological_processproteolysis
X0010498biological_processproteasomal protein catabolic process
X0019774cellular_componentproteasome core complex, beta-subunit complex
X0019941biological_processmodification-dependent protein catabolic process
X0030682biological_processsymbiont-mediated perturbation of host defenses
X0035375molecular_functionzymogen binding
X0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
X0051603biological_processproteolysis involved in protein catabolic process
Y0000502cellular_componentproteasome complex
Y0004175molecular_functionendopeptidase activity
Y0004298molecular_functionthreonine-type endopeptidase activity
Y0005515molecular_functionprotein binding
Y0005576cellular_componentextracellular region
Y0005737cellular_componentcytoplasm
Y0005839cellular_componentproteasome core complex
Y0005886cellular_componentplasma membrane
Y0006508biological_processproteolysis
Y0010498biological_processproteasomal protein catabolic process
Y0019774cellular_componentproteasome core complex, beta-subunit complex
Y0019941biological_processmodification-dependent protein catabolic process
Y0030682biological_processsymbiont-mediated perturbation of host defenses
Y0035375molecular_functionzymogen binding
Y0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Y0051603biological_processproteolysis involved in protein catabolic process
Z0000502cellular_componentproteasome complex
Z0004175molecular_functionendopeptidase activity
Z0004298molecular_functionthreonine-type endopeptidase activity
Z0005515molecular_functionprotein binding
Z0005576cellular_componentextracellular region
Z0005737cellular_componentcytoplasm
Z0005839cellular_componentproteasome core complex
Z0005886cellular_componentplasma membrane
Z0006508biological_processproteolysis
Z0010498biological_processproteasomal protein catabolic process
Z0019774cellular_componentproteasome core complex, beta-subunit complex
Z0019941biological_processmodification-dependent protein catabolic process
Z0030682biological_processsymbiont-mediated perturbation of host defenses
Z0035375molecular_functionzymogen binding
Z0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
Z0051603biological_processproteolysis involved in protein catabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsACT_SITE: Nucleophile => ECO:0000305|PubMed:20711362
ChainResidueDetails
PTHR301
YTHR301
ZTHR301
aTHR301
bTHR301
cTHR301
QTHR301
RTHR301
STHR301
TTHR301
UTHR301
VTHR301
WTHR301
XTHR301

site_idSWS_FT_FI2
Number of Residues14
DetailsSITE: Covalent link with the inhibitor MLN-273 => ECO:0000269|PubMed:16468986
ChainResidueDetails
PTHR301
YTHR301
ZTHR301
aTHR301
bTHR301
cTHR301
FTHR202
GTHR84
GTHR178
GTHR202
HTHR84
QTHR301
HTHR178
HTHR202
ITHR84
ITHR178
ITHR202
JTHR84
JTHR178
JTHR202
KTHR84
KTHR178
RTHR301
KTHR202
LTHR84
LTHR178
LTHR202
MTHR84
MTHR178
MTHR202
NTHR84
NTHR178
NTHR202
STHR301
OTHR84
OTHR178
OTHR202
TTHR301
UTHR301
VTHR301
WTHR301
XTHR301

222036

PDB entries from 2024-07-03

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