8D57

Crystal Structure of dihydrodipicolinate reductase from Acinetobacter baumannii

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase
A	0009085	biological_process	lysine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0016491	molecular_function	oxidoreductase activity
A	0016726	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
A	0019877	biological_process	diaminopimelate biosynthetic process
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase
B	0009085	biological_process	lysine biosynthetic process
B	0009089	biological_process	lysine biosynthetic process via diaminopimelate
B	0016491	molecular_function	oxidoreductase activity
B	0016726	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
B	0019877	biological_process	diaminopimelate biosynthetic process
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase
C	0009085	biological_process	lysine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0016491	molecular_function	oxidoreductase activity
C	0016726	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
C	0019877	biological_process	diaminopimelate biosynthetic process
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase
D	0009085	biological_process	lysine biosynthetic process
D	0009089	biological_process	lysine biosynthetic process via diaminopimelate
D	0016491	molecular_function	oxidoreductase activity
D	0016726	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
D	0019877	biological_process	diaminopimelate biosynthetic process
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase
E	0009085	biological_process	lysine biosynthetic process
E	0009089	biological_process	lysine biosynthetic process via diaminopimelate
E	0016491	molecular_function	oxidoreductase activity
E	0016726	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
E	0019877	biological_process	diaminopimelate biosynthetic process
E	0050661	molecular_function	NADP binding
E	0051287	molecular_function	NAD binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0008839	molecular_function	4-hydroxy-tetrahydrodipicolinate reductase
F	0009085	biological_process	lysine biosynthetic process
F	0009089	biological_process	lysine biosynthetic process via diaminopimelate
F	0016491	molecular_function	oxidoreductase activity
F	0016726	molecular_function	oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
F	0019877	biological_process	diaminopimelate biosynthetic process
F	0050661	molecular_function	NADP binding
F	0051287	molecular_function	NAD binding

Functional Information from PROSITE/UniProt

site_id	PS01298
Number of Residues	18
Details	DAPB Dihydrodipicolinate reductase signature. EViEaHhrhKvDapSGTA

Chain	Residue	Details
A	GLU152-ALA169

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00102

Chain	Residue	Details
A	HIS157
B	HIS157
C	HIS157
D	HIS157
E	HIS157
F	HIS157

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_00102

Chain	Residue	Details
A	LYS161
B	LYS161
C	LYS161
D	LYS161
E	LYS161
F	LYS161

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site_id	SWS_FT_FI3
Number of Residues	36
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00102

Chain	Residue	Details
A	GLY11
B	ALA124
B	HIS158
B	GLY167
C	GLY11
C	ARG37
C	GLY100
C	ALA124
C	HIS158
C	GLY167
D	GLY11
A	ARG37
D	ARG37
D	GLY100
D	ALA124
D	HIS158
D	GLY167
E	GLY11
E	ARG37
E	GLY100
E	ALA124
E	HIS158
A	GLY100
E	GLY167
F	GLY11
F	ARG37
F	GLY100
F	ALA124
F	HIS158
F	GLY167
A	ALA124
A	HIS158
A	GLY167
B	GLY11
B	ARG37
B	GLY100

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