8D4S

Crystal Structure of Cathepsin G Inhibited by Eap1 from S. aureus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002003	biological_process	angiotensin maturation
A	0002548	biological_process	monocyte chemotaxis
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005764	cellular_component	lysosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0006935	biological_process	chemotaxis
A	0006955	biological_process	immune response
A	0008201	molecular_function	heparin binding
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0010494	cellular_component	cytoplasmic stress granule
A	0016020	cellular_component	membrane
A	0016485	biological_process	protein processing
A	0016787	molecular_function	hydrolase activity
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0019731	biological_process	antibacterial humoral response
A	0022617	biological_process	extracellular matrix disassembly
A	0030141	cellular_component	secretory granule
A	0030168	biological_process	platelet activation
A	0031012	cellular_component	extracellular matrix
A	0035578	cellular_component	azurophil granule lumen
A	0035590	biological_process	purinergic nucleotide receptor signaling pathway
A	0042119	biological_process	neutrophil activation
A	0042742	biological_process	defense response to bacterium
A	0048018	molecular_function	receptor ligand activity
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0050868	biological_process	negative regulation of T cell activation
A	0051604	biological_process	protein maturation
A	0070062	cellular_component	extracellular exosome
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0089720	molecular_function	caspase binding
A	0098786	biological_process	biofilm matrix disassembly
A	1901731	biological_process	positive regulation of platelet aggregation
B	0005576	cellular_component	extracellular region
C	0002003	biological_process	angiotensin maturation
C	0002548	biological_process	monocyte chemotaxis
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005764	cellular_component	lysosome
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0006935	biological_process	chemotaxis
C	0006955	biological_process	immune response
C	0008201	molecular_function	heparin binding
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0010494	cellular_component	cytoplasmic stress granule
C	0016020	cellular_component	membrane
C	0016485	biological_process	protein processing
C	0016787	molecular_function	hydrolase activity
C	0019221	biological_process	cytokine-mediated signaling pathway
C	0019731	biological_process	antibacterial humoral response
C	0022617	biological_process	extracellular matrix disassembly
C	0030141	cellular_component	secretory granule
C	0030168	biological_process	platelet activation
C	0031012	cellular_component	extracellular matrix
C	0035578	cellular_component	azurophil granule lumen
C	0035590	biological_process	purinergic nucleotide receptor signaling pathway
C	0042119	biological_process	neutrophil activation
C	0042742	biological_process	defense response to bacterium
C	0048018	molecular_function	receptor ligand activity
C	0050829	biological_process	defense response to Gram-negative bacterium
C	0050830	biological_process	defense response to Gram-positive bacterium
C	0050868	biological_process	negative regulation of T cell activation
C	0051604	biological_process	protein maturation
C	0070062	cellular_component	extracellular exosome
C	0071222	biological_process	cellular response to lipopolysaccharide
C	0089720	molecular_function	caspase binding
C	0098786	biological_process	biofilm matrix disassembly
C	1901731	biological_process	positive regulation of platelet aggregation
D	0005576	cellular_component	extracellular region
E	0002003	biological_process	angiotensin maturation
E	0002548	biological_process	monocyte chemotaxis
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005764	cellular_component	lysosome
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006508	biological_process	proteolysis
E	0006935	biological_process	chemotaxis
E	0006955	biological_process	immune response
E	0008201	molecular_function	heparin binding
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0010494	cellular_component	cytoplasmic stress granule
E	0016020	cellular_component	membrane
E	0016485	biological_process	protein processing
E	0016787	molecular_function	hydrolase activity
E	0019221	biological_process	cytokine-mediated signaling pathway
E	0019731	biological_process	antibacterial humoral response
E	0022617	biological_process	extracellular matrix disassembly
E	0030141	cellular_component	secretory granule
E	0030168	biological_process	platelet activation
E	0031012	cellular_component	extracellular matrix
E	0035578	cellular_component	azurophil granule lumen
E	0035590	biological_process	purinergic nucleotide receptor signaling pathway
E	0042119	biological_process	neutrophil activation
E	0042742	biological_process	defense response to bacterium
E	0048018	molecular_function	receptor ligand activity
E	0050829	biological_process	defense response to Gram-negative bacterium
E	0050830	biological_process	defense response to Gram-positive bacterium
E	0050868	biological_process	negative regulation of T cell activation
E	0051604	biological_process	protein maturation
E	0070062	cellular_component	extracellular exosome
E	0071222	biological_process	cellular response to lipopolysaccharide
E	0089720	molecular_function	caspase binding
E	0098786	biological_process	biofilm matrix disassembly
E	1901731	biological_process	positive regulation of platelet aggregation
F	0005576	cellular_component	extracellular region
G	0002003	biological_process	angiotensin maturation
G	0002548	biological_process	monocyte chemotaxis
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005634	cellular_component	nucleus
G	0005764	cellular_component	lysosome
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006508	biological_process	proteolysis
G	0006935	biological_process	chemotaxis
G	0006955	biological_process	immune response
G	0008201	molecular_function	heparin binding
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0010494	cellular_component	cytoplasmic stress granule
G	0016020	cellular_component	membrane
G	0016485	biological_process	protein processing
G	0016787	molecular_function	hydrolase activity
G	0019221	biological_process	cytokine-mediated signaling pathway
G	0019731	biological_process	antibacterial humoral response
G	0022617	biological_process	extracellular matrix disassembly
G	0030141	cellular_component	secretory granule
G	0030168	biological_process	platelet activation
G	0031012	cellular_component	extracellular matrix
G	0035578	cellular_component	azurophil granule lumen
G	0035590	biological_process	purinergic nucleotide receptor signaling pathway
G	0042119	biological_process	neutrophil activation
G	0042742	biological_process	defense response to bacterium
G	0048018	molecular_function	receptor ligand activity
G	0050829	biological_process	defense response to Gram-negative bacterium
G	0050830	biological_process	defense response to Gram-positive bacterium
G	0050868	biological_process	negative regulation of T cell activation
G	0051604	biological_process	protein maturation
G	0070062	cellular_component	extracellular exosome
G	0071222	biological_process	cellular response to lipopolysaccharide
G	0089720	molecular_function	caspase binding
G	0098786	biological_process	biofilm matrix disassembly
G	1901731	biological_process	positive regulation of platelet aggregation
H	0005576	cellular_component	extracellular region

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU55-CYS60

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. AAfkGDSGGPLL

Chain	Residue	Details
A	ALA190-LEU201

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	888
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	72
Details	Region: {"description":"Important for antimicrobial activity","evidences":[{"source":"PubMed","id":"2116408","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (paucimannose) asparagine; alternate","evidences":[{"source":"PubMed","id":"26274980","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---