8D45

Cryo-EM structure of human Kidney Betaine-Homocysteine Methyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005829	cellular_component	cytosol
A	0006575	biological_process	modified amino acid metabolic process
A	0006577	biological_process	amino-acid betaine metabolic process
A	0006579	biological_process	amino-acid betaine catabolic process
A	0008168	molecular_function	methyltransferase activity
A	0008172	molecular_function	S-methyltransferase activity
A	0008270	molecular_function	zinc ion binding
A	0009086	biological_process	obsolete methionine biosynthetic process
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation
A	0046500	biological_process	S-adenosylmethionine metabolic process
A	0046872	molecular_function	metal ion binding
A	0047150	molecular_function	betaine-homocysteine S-methyltransferase activity
A	0070062	cellular_component	extracellular exosome
A	0071266	biological_process	'de novo' L-methionine biosynthetic process
A	0071267	biological_process	L-methionine salvage
B	0005634	cellular_component	nucleus
B	0005829	cellular_component	cytosol
B	0006575	biological_process	modified amino acid metabolic process
B	0006577	biological_process	amino-acid betaine metabolic process
B	0006579	biological_process	amino-acid betaine catabolic process
B	0008168	molecular_function	methyltransferase activity
B	0008172	molecular_function	S-methyltransferase activity
B	0008270	molecular_function	zinc ion binding
B	0009086	biological_process	obsolete methionine biosynthetic process
B	0016740	molecular_function	transferase activity
B	0032259	biological_process	methylation
B	0046500	biological_process	S-adenosylmethionine metabolic process
B	0046872	molecular_function	metal ion binding
B	0047150	molecular_function	betaine-homocysteine S-methyltransferase activity
B	0070062	cellular_component	extracellular exosome
B	0071266	biological_process	'de novo' L-methionine biosynthetic process
B	0071267	biological_process	L-methionine salvage
C	0005634	cellular_component	nucleus
C	0005829	cellular_component	cytosol
C	0006575	biological_process	modified amino acid metabolic process
C	0006577	biological_process	amino-acid betaine metabolic process
C	0006579	biological_process	amino-acid betaine catabolic process
C	0008168	molecular_function	methyltransferase activity
C	0008172	molecular_function	S-methyltransferase activity
C	0008270	molecular_function	zinc ion binding
C	0009086	biological_process	obsolete methionine biosynthetic process
C	0016740	molecular_function	transferase activity
C	0032259	biological_process	methylation
C	0046500	biological_process	S-adenosylmethionine metabolic process
C	0046872	molecular_function	metal ion binding
C	0047150	molecular_function	betaine-homocysteine S-methyltransferase activity
C	0070062	cellular_component	extracellular exosome
C	0071266	biological_process	'de novo' L-methionine biosynthetic process
C	0071267	biological_process	L-methionine salvage
D	0005634	cellular_component	nucleus
D	0005829	cellular_component	cytosol
D	0006575	biological_process	modified amino acid metabolic process
D	0006577	biological_process	amino-acid betaine metabolic process
D	0006579	biological_process	amino-acid betaine catabolic process
D	0008168	molecular_function	methyltransferase activity
D	0008172	molecular_function	S-methyltransferase activity
D	0008270	molecular_function	zinc ion binding
D	0009086	biological_process	obsolete methionine biosynthetic process
D	0016740	molecular_function	transferase activity
D	0032259	biological_process	methylation
D	0046500	biological_process	S-adenosylmethionine metabolic process
D	0046872	molecular_function	metal ion binding
D	0047150	molecular_function	betaine-homocysteine S-methyltransferase activity
D	0070062	cellular_component	extracellular exosome
D	0071266	biological_process	'de novo' L-methionine biosynthetic process
D	0071267	biological_process	L-methionine salvage

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00333","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12220488","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LT8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"O35490","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O09171","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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