8D3X
Human alpha3 Na+/K+-ATPase in its K+-occluded state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001540 | molecular_function | amyloid-beta binding |
| A | 0001917 | cellular_component | photoreceptor inner segment |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005391 | molecular_function | P-type sodium:potassium-exchanging transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005890 | cellular_component | sodium:potassium-exchanging ATPase complex |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006883 | biological_process | intracellular sodium ion homeostasis |
| A | 0008556 | molecular_function | P-type potassium transmembrane transporter activity |
| A | 0010248 | biological_process | establishment or maintenance of transmembrane electrochemical gradient |
| A | 0016020 | cellular_component | membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030007 | biological_process | intracellular potassium ion homeostasis |
| A | 0030424 | cellular_component | axon |
| A | 0032809 | cellular_component | neuronal cell body membrane |
| A | 0036376 | biological_process | sodium ion export across plasma membrane |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045202 | cellular_component | synapse |
| A | 0051087 | molecular_function | protein-folding chaperone binding |
| A | 0060075 | biological_process | regulation of resting membrane potential |
| A | 0060342 | cellular_component | photoreceptor inner segment membrane |
| A | 0071383 | biological_process | cellular response to steroid hormone stimulus |
| A | 0086064 | biological_process | cell communication by electrical coupling involved in cardiac conduction |
| A | 0098984 | cellular_component | neuron to neuron synapse |
| A | 1903416 | biological_process | response to glycoside |
| A | 1903561 | cellular_component | extracellular vesicle |
| A | 1904646 | biological_process | cellular response to amyloid-beta |
| A | 1990239 | molecular_function | steroid hormone binding |
| A | 1990535 | biological_process | neuron projection maintenance |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 0001666 | biological_process | response to hypoxia |
| B | 0001671 | molecular_function | ATPase activator activity |
| B | 0005391 | molecular_function | P-type sodium:potassium-exchanging transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005890 | cellular_component | sodium:potassium-exchanging ATPase complex |
| B | 0005901 | cellular_component | caveola |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0006874 | biological_process | intracellular calcium ion homeostasis |
| B | 0006883 | biological_process | intracellular sodium ion homeostasis |
| B | 0010248 | biological_process | establishment or maintenance of transmembrane electrochemical gradient |
| B | 0010468 | biological_process | regulation of gene expression |
| B | 0010882 | biological_process | regulation of cardiac muscle contraction by calcium ion signaling |
| B | 0014704 | cellular_component | intercalated disc |
| B | 0016020 | cellular_component | membrane |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0016328 | cellular_component | lateral plasma membrane |
| B | 0019901 | molecular_function | protein kinase binding |
| B | 0023026 | molecular_function | MHC class II protein complex binding |
| B | 0030001 | biological_process | metal ion transport |
| B | 0030007 | biological_process | intracellular potassium ion homeostasis |
| B | 0030315 | cellular_component | T-tubule |
| B | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0036126 | cellular_component | sperm flagellum |
| B | 0036376 | biological_process | sodium ion export across plasma membrane |
| B | 0042383 | cellular_component | sarcolemma |
| B | 0044861 | biological_process | protein transport into plasma membrane raft |
| B | 0046034 | biological_process | ATP metabolic process |
| B | 0046982 | molecular_function | protein heterodimerization activity |
| B | 0050821 | biological_process | protein stabilization |
| B | 0051117 | molecular_function | ATPase binding |
| B | 0055119 | biological_process | relaxation of cardiac muscle |
| B | 0060048 | biological_process | cardiac muscle contraction |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0072659 | biological_process | protein localization to plasma membrane |
| B | 0086009 | biological_process | membrane repolarization |
| B | 0086013 | biological_process | membrane repolarization during cardiac muscle cell action potential |
| B | 0086064 | biological_process | cell communication by electrical coupling involved in cardiac conduction |
| B | 0141109 | molecular_function | transporter activator activity |
| B | 1902600 | biological_process | proton transmembrane transport |
| B | 1903169 | biological_process | regulation of calcium ion transmembrane transport |
| B | 1903278 | biological_process | positive regulation of sodium ion export across plasma membrane |
| B | 1903288 | biological_process | positive regulation of potassium ion import across plasma membrane |
| B | 1903561 | cellular_component | extracellular vesicle |
| B | 1990573 | biological_process | potassium ion import across plasma membrane |
| G | 0016020 | cellular_component | membrane |
| G | 0043269 | biological_process | regulation of monoatomic ion transport |
| G | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PROSITE/UniProt
| site_id | PS00154 |
| Number of Residues | 7 |
| Details | ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT |
| Chain | Residue | Details |
| A | ASP366-THR372 |
| site_id | PS00390 |
| Number of Residues | 21 |
| Details | ATPASE_NA_K_BETA_1 Sodium and potassium ATPases beta subunits signature 1. WkkFiWNsekkefLGRTggsW |
| Chain | Residue | Details |
| B | TRP12-TRP32 |
| site_id | PS00391 |
| Number of Residues | 16 |
| Details | ATPASE_NA_K_BETA_2 Sodium and potassium ATPases beta subunits signature 2. RkvCRfklewLgnCSG |
| Chain | Residue | Details |
| B | ARG146-GLY161 |
| site_id | PS01310 |
| Number of Residues | 14 |
| Details | FXYD FXYD family signature. DpFhYDyqTLRigG |
| Chain | Residue | Details |
| G | ASP28-GLY41 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 112 |
| Details | Region: {"description":"immunoglobulin-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P14094","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"36075933","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D3V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 66 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36075933","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 621 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36075933","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 38 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 15 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 23 |
| Details | Transmembrane: {"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | Region: {"description":"Interaction with phosphoinositide-3 kinase","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"source":"UniProtKB","id":"P19156","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13733","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI23 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"36075933","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8D3U","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI24 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P06687","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI25 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q6PIC6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI26 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q6PIC6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI27 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
