8D3H
Crystal structure of human Apoptosis-Inducing Factor (AIF) W196A mutant complexed with 7-chloroquinolin-4-amine
Functional Information from GO Data
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVI |
Chain | Residue | Details |
B | GLY138 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVH, ECO:0007744|PDB:5KVI |
Chain | Residue | Details |
B | GLU164 | |
B | ARG172 | |
B | VAL233 | |
B | ASP438 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVI |
Chain | Residue | Details |
B | LYS177 |
site_id | SWS_FT_FI4 |
Number of Residues | 7 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24914854, ECO:0007744|PDB:4BUR |
Chain | Residue | Details |
B | ALA196 | |
B | GLY308 | |
B | GLU336 | |
B | GLY399 | |
B | GLU453 | |
B | GLU493 | |
B | ASN583 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:23217327, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVH |
Chain | Residue | Details |
B | ARG285 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:Q9Z0X1 |
Chain | Residue | Details |
B | LYS342 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12198487, ECO:0000269|PubMed:24914854, ECO:0000269|PubMed:27178839, ECO:0000269|PubMed:27818101, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6, ECO:0007744|PDB:5FS7, ECO:0007744|PDB:5FS8, ECO:0007744|PDB:5FS9, ECO:0007744|PDB:5KVH, ECO:0007744|PDB:5KVI |
Chain | Residue | Details |
B | HIS454 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000269|PubMed:24914854, ECO:0007744|PDB:4BUR, ECO:0007744|PDB:4BV6 |
Chain | Residue | Details |
B | TRP483 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
B | THR105 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9Z0X1 |
Chain | Residue | Details |
B | LYS109 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
B | SER116 |
site_id | SWS_FT_FI12 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
B | SER118 | |
B | SER371 | |
B | SER524 | |
B | SER530 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
B | SER268 |
site_id | SWS_FT_FI14 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
B | SER292 |
site_id | SWS_FT_FI15 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9Z0X1 |
Chain | Residue | Details |
B | LYS388 | |
B | LYS593 |
site_id | SWS_FT_FI16 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
B | THR521 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:22103349 |
Chain | Residue | Details |
B | LYS255 |