8D0A
Crystal structure of human USP30 in complex with a covalent inhibitor 829 and a Fab
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 |
| site_id | PS00972 |
| Number of Residues | 16 |
| Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLvnlGNtCFMNSlLQ |
| Chain | Residue | Details |
| A | GLY69-GLN84 |
| site_id | PS00973 |
| Number of Residues | 18 |
| Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. FrLmAVvvHhGdmhs..GHF |
| Chain | Residue | Details |
| A | PHE436-PHE453 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25621951 |
| Chain | Residue | Details |
| A | CYS77 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093 |
| Chain | Residue | Details |
| A | HIS452 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:24896179 |
| Chain | Residue | Details |
| A | LYS235 | |
| A | LYS289 |
