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8CZ0

CryoEM structure of amplified alpha-synuclein fibril class B type I with extended core from DLB case VII

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000149molecular_functionSNARE binding
A0000287molecular_functionmagnesium ion binding
A0000976molecular_functiontranscription cis-regulatory region binding
A0001774biological_processmicroglial cell activation
A0001921biological_processpositive regulation of receptor recycling
A0001956biological_processpositive regulation of neurotransmitter secretion
A0001963biological_processsynaptic transmission, dopaminergic
A0003779molecular_functionactin binding
A0004860molecular_functionprotein kinase inhibitor activity
A0005504molecular_functionfatty acid binding
A0005507molecular_functioncopper ion binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005543molecular_functionphospholipid binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005938cellular_componentcell cortex
A0006469biological_processnegative regulation of protein kinase activity
A0006631biological_processfatty acid metabolic process
A0006638biological_processneutral lipid metabolic process
A0006644biological_processphospholipid metabolic process
A0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
A0007006biological_processmitochondrial membrane organization
A0007268biological_processchemical synaptic transmission
A0007269biological_processneurotransmitter secretion
A0008198molecular_functionferrous iron binding
A0008270molecular_functionzinc ion binding
A0008289molecular_functionlipid binding
A0008344biological_processadult locomotory behavior
A0009410biological_processresponse to xenobiotic stimulus
A0010040biological_processresponse to iron(II) ion
A0010517biological_processregulation of phospholipase activity
A0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
A0014048biological_processregulation of glutamate secretion
A0014059biological_processregulation of dopamine secretion
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0016079biological_processsynaptic vesicle exocytosis
A0016082biological_processsynaptic vesicle priming
A0016234cellular_componentinclusion body
A0016491molecular_functionoxidoreductase activity
A0019894molecular_functionkinesin binding
A0022898biological_processregulation of transmembrane transporter activity
A0030424cellular_componentaxon
A0030426cellular_componentgrowth cone
A0030544molecular_functionHsp70 protein binding
A0030672cellular_componentsynaptic vesicle membrane
A0031092cellular_componentplatelet alpha granule membrane
A0031115biological_processnegative regulation of microtubule polymerization
A0031623biological_processreceptor internalization
A0031648biological_processprotein destabilization
A0032026biological_processresponse to magnesium ion
A0032410biological_processnegative regulation of transporter activity
A0032496biological_processresponse to lipopolysaccharide
A0032769biological_processnegative regulation of monooxygenase activity
A0032991cellular_componentprotein-containing complex
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0034341biological_processresponse to type II interferon
A0034599biological_processcellular response to oxidative stress
A0035493biological_processSNARE complex assembly
A0035543biological_processpositive regulation of SNARE complex assembly
A0040012biological_processregulation of locomotion
A0042393molecular_functionhistone binding
A0042416biological_processdopamine biosynthetic process
A0042417biological_processdopamine metabolic process
A0042775biological_processmitochondrial ATP synthesis coupled electron transport
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043014molecular_functionalpha-tubulin binding
A0043025cellular_componentneuronal cell body
A0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
A0043030biological_processregulation of macrophage activation
A0043065biological_processpositive regulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0043679cellular_componentaxon terminus
A0045202cellular_componentsynapse
A0045807biological_processpositive regulation of endocytosis
A0045920biological_processnegative regulation of exocytosis
A0045921biological_processpositive regulation of exocytosis
A0046872molecular_functionmetal ion binding
A0046928biological_processregulation of neurotransmitter secretion
A0048156molecular_functiontau protein binding
A0048168biological_processregulation of neuronal synaptic plasticity
A0048169biological_processregulation of long-term neuronal synaptic plasticity
A0048471cellular_componentperinuclear region of cytoplasm
A0048488biological_processsynaptic vesicle endocytosis
A0048489biological_processsynaptic vesicle transport
A0050729biological_processpositive regulation of inflammatory response
A0050806biological_processpositive regulation of synaptic transmission
A0050808biological_processsynapse organization
A0050812biological_processregulation of acyl-CoA biosynthetic process
A0051219molecular_functionphosphoprotein binding
A0051259biological_processprotein complex oligomerization
A0051262biological_processprotein tetramerization
A0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
A0051402biological_processneuron apoptotic process
A0051583biological_processdopamine uptake involved in synaptic transmission
A0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
A0051612biological_processnegative regulation of serotonin uptake
A0051621biological_processregulation of norepinephrine uptake
A0051622biological_processnegative regulation of norepinephrine uptake
A0055074biological_processcalcium ion homeostasis
A0060079biological_processexcitatory postsynaptic potential
A0060090molecular_functionmolecular adaptor activity
A0060291biological_processlong-term synaptic potentiation
A0060732biological_processpositive regulation of inositol phosphate biosynthetic process
A0060961molecular_functionphospholipase D inhibitor activity
A0061024biological_processmembrane organization
A0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
A0070555biological_processresponse to interleukin-1
A0070840molecular_functiondynein complex binding
A0071280biological_processcellular response to copper ion
A0071872biological_processcellular response to epinephrine stimulus
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0097435biological_processsupramolecular fiber organization
A0098794cellular_componentpostsynapse
A0099512cellular_componentsupramolecular fiber
A1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
A1903136molecular_functioncuprous ion binding
A1903284biological_processpositive regulation of glutathione peroxidase activity
A1903285biological_processpositive regulation of hydrogen peroxide catabolic process
A1903421biological_processregulation of synaptic vesicle recycling
A1903426biological_processregulation of reactive oxygen species biosynthetic process
A1904377biological_processpositive regulation of protein localization to cell periphery
A1904715biological_processnegative regulation of chaperone-mediated autophagy
A1905606biological_processregulation of presynapse assembly
A1990000biological_processamyloid fibril formation
A2000377biological_processregulation of reactive oxygen species metabolic process
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000149molecular_functionSNARE binding
B0000287molecular_functionmagnesium ion binding
B0000976molecular_functiontranscription cis-regulatory region binding
B0001774biological_processmicroglial cell activation
B0001921biological_processpositive regulation of receptor recycling
B0001956biological_processpositive regulation of neurotransmitter secretion
B0001963biological_processsynaptic transmission, dopaminergic
B0003779molecular_functionactin binding
B0004860molecular_functionprotein kinase inhibitor activity
B0005504molecular_functionfatty acid binding
B0005507molecular_functioncopper ion binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005543molecular_functionphospholipid binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005764cellular_componentlysosome
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005938cellular_componentcell cortex
B0006469biological_processnegative regulation of protein kinase activity
B0006631biological_processfatty acid metabolic process
B0006638biological_processneutral lipid metabolic process
B0006644biological_processphospholipid metabolic process
B0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
B0007006biological_processmitochondrial membrane organization
B0007268biological_processchemical synaptic transmission
B0007269biological_processneurotransmitter secretion
B0008198molecular_functionferrous iron binding
B0008270molecular_functionzinc ion binding
B0008289molecular_functionlipid binding
B0008344biological_processadult locomotory behavior
B0009410biological_processresponse to xenobiotic stimulus
B0010040biological_processresponse to iron(II) ion
B0010517biological_processregulation of phospholipase activity
B0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
B0014048biological_processregulation of glutamate secretion
B0014059biological_processregulation of dopamine secretion
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0016079biological_processsynaptic vesicle exocytosis
B0016082biological_processsynaptic vesicle priming
B0016234cellular_componentinclusion body
B0016491molecular_functionoxidoreductase activity
B0019894molecular_functionkinesin binding
B0022898biological_processregulation of transmembrane transporter activity
B0030424cellular_componentaxon
B0030426cellular_componentgrowth cone
B0030544molecular_functionHsp70 protein binding
B0030672cellular_componentsynaptic vesicle membrane
B0031092cellular_componentplatelet alpha granule membrane
B0031115biological_processnegative regulation of microtubule polymerization
B0031623biological_processreceptor internalization
B0031648biological_processprotein destabilization
B0032026biological_processresponse to magnesium ion
B0032410biological_processnegative regulation of transporter activity
B0032496biological_processresponse to lipopolysaccharide
B0032769biological_processnegative regulation of monooxygenase activity
B0032991cellular_componentprotein-containing complex
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0034341biological_processresponse to type II interferon
B0034599biological_processcellular response to oxidative stress
B0035493biological_processSNARE complex assembly
B0035543biological_processpositive regulation of SNARE complex assembly
B0040012biological_processregulation of locomotion
B0042393molecular_functionhistone binding
B0042416biological_processdopamine biosynthetic process
B0042417biological_processdopamine metabolic process
B0042775biological_processmitochondrial ATP synthesis coupled electron transport
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043014molecular_functionalpha-tubulin binding
B0043025cellular_componentneuronal cell body
B0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
B0043030biological_processregulation of macrophage activation
B0043065biological_processpositive regulation of apoptotic process
B0043066biological_processnegative regulation of apoptotic process
B0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
B0043524biological_processnegative regulation of neuron apoptotic process
B0043679cellular_componentaxon terminus
B0045202cellular_componentsynapse
B0045807biological_processpositive regulation of endocytosis
B0045920biological_processnegative regulation of exocytosis
B0045921biological_processpositive regulation of exocytosis
B0046872molecular_functionmetal ion binding
B0046928biological_processregulation of neurotransmitter secretion
B0048156molecular_functiontau protein binding
B0048168biological_processregulation of neuronal synaptic plasticity
B0048169biological_processregulation of long-term neuronal synaptic plasticity
B0048471cellular_componentperinuclear region of cytoplasm
B0048488biological_processsynaptic vesicle endocytosis
B0048489biological_processsynaptic vesicle transport
B0050729biological_processpositive regulation of inflammatory response
B0050806biological_processpositive regulation of synaptic transmission
B0050808biological_processsynapse organization
B0050812biological_processregulation of acyl-CoA biosynthetic process
B0051219molecular_functionphosphoprotein binding
B0051259biological_processprotein complex oligomerization
B0051262biological_processprotein tetramerization
B0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
B0051402biological_processneuron apoptotic process
B0051583biological_processdopamine uptake involved in synaptic transmission
B0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
B0051612biological_processnegative regulation of serotonin uptake
B0051621biological_processregulation of norepinephrine uptake
B0051622biological_processnegative regulation of norepinephrine uptake
B0055074biological_processcalcium ion homeostasis
B0060079biological_processexcitatory postsynaptic potential
B0060090molecular_functionmolecular adaptor activity
B0060291biological_processlong-term synaptic potentiation
B0060732biological_processpositive regulation of inositol phosphate biosynthetic process
B0060961molecular_functionphospholipase D inhibitor activity
B0061024biological_processmembrane organization
B0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
B0070555biological_processresponse to interleukin-1
B0070840molecular_functiondynein complex binding
B0071280biological_processcellular response to copper ion
B0071872biological_processcellular response to epinephrine stimulus
B0071902biological_processpositive regulation of protein serine/threonine kinase activity
B0097435biological_processsupramolecular fiber organization
B0098794cellular_componentpostsynapse
B0099512cellular_componentsupramolecular fiber
B1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
B1903136molecular_functioncuprous ion binding
B1903284biological_processpositive regulation of glutathione peroxidase activity
B1903285biological_processpositive regulation of hydrogen peroxide catabolic process
B1903421biological_processregulation of synaptic vesicle recycling
B1903426biological_processregulation of reactive oxygen species biosynthetic process
B1904377biological_processpositive regulation of protein localization to cell periphery
B1904715biological_processnegative regulation of chaperone-mediated autophagy
B1905606biological_processregulation of presynapse assembly
B1990000biological_processamyloid fibril formation
B2000377biological_processregulation of reactive oxygen species metabolic process
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000149molecular_functionSNARE binding
C0000287molecular_functionmagnesium ion binding
C0000976molecular_functiontranscription cis-regulatory region binding
C0001774biological_processmicroglial cell activation
C0001921biological_processpositive regulation of receptor recycling
C0001956biological_processpositive regulation of neurotransmitter secretion
C0001963biological_processsynaptic transmission, dopaminergic
C0003779molecular_functionactin binding
C0004860molecular_functionprotein kinase inhibitor activity
C0005504molecular_functionfatty acid binding
C0005507molecular_functioncopper ion binding
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005543molecular_functionphospholipid binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005764cellular_componentlysosome
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005938cellular_componentcell cortex
C0006469biological_processnegative regulation of protein kinase activity
C0006631biological_processfatty acid metabolic process
C0006638biological_processneutral lipid metabolic process
C0006644biological_processphospholipid metabolic process
C0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
C0007006biological_processmitochondrial membrane organization
C0007268biological_processchemical synaptic transmission
C0007269biological_processneurotransmitter secretion
C0008198molecular_functionferrous iron binding
C0008270molecular_functionzinc ion binding
C0008289molecular_functionlipid binding
C0008344biological_processadult locomotory behavior
C0009410biological_processresponse to xenobiotic stimulus
C0010040biological_processresponse to iron(II) ion
C0010517biological_processregulation of phospholipase activity
C0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
C0014048biological_processregulation of glutamate secretion
C0014059biological_processregulation of dopamine secretion
C0015629cellular_componentactin cytoskeleton
C0016020cellular_componentmembrane
C0016079biological_processsynaptic vesicle exocytosis
C0016082biological_processsynaptic vesicle priming
C0016234cellular_componentinclusion body
C0016491molecular_functionoxidoreductase activity
C0019894molecular_functionkinesin binding
C0022898biological_processregulation of transmembrane transporter activity
C0030424cellular_componentaxon
C0030426cellular_componentgrowth cone
C0030544molecular_functionHsp70 protein binding
C0030672cellular_componentsynaptic vesicle membrane
C0031092cellular_componentplatelet alpha granule membrane
C0031115biological_processnegative regulation of microtubule polymerization
C0031623biological_processreceptor internalization
C0031648biological_processprotein destabilization
C0032026biological_processresponse to magnesium ion
C0032410biological_processnegative regulation of transporter activity
C0032496biological_processresponse to lipopolysaccharide
C0032769biological_processnegative regulation of monooxygenase activity
C0032991cellular_componentprotein-containing complex
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0034341biological_processresponse to type II interferon
C0034599biological_processcellular response to oxidative stress
C0035493biological_processSNARE complex assembly
C0035543biological_processpositive regulation of SNARE complex assembly
C0040012biological_processregulation of locomotion
C0042393molecular_functionhistone binding
C0042416biological_processdopamine biosynthetic process
C0042417biological_processdopamine metabolic process
C0042775biological_processmitochondrial ATP synthesis coupled electron transport
C0042802molecular_functionidentical protein binding
C0042995cellular_componentcell projection
C0043014molecular_functionalpha-tubulin binding
C0043025cellular_componentneuronal cell body
C0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
C0043030biological_processregulation of macrophage activation
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
C0043524biological_processnegative regulation of neuron apoptotic process
C0043679cellular_componentaxon terminus
C0045202cellular_componentsynapse
C0045807biological_processpositive regulation of endocytosis
C0045920biological_processnegative regulation of exocytosis
C0045921biological_processpositive regulation of exocytosis
C0046872molecular_functionmetal ion binding
C0046928biological_processregulation of neurotransmitter secretion
C0048156molecular_functiontau protein binding
C0048168biological_processregulation of neuronal synaptic plasticity
C0048169biological_processregulation of long-term neuronal synaptic plasticity
C0048471cellular_componentperinuclear region of cytoplasm
C0048488biological_processsynaptic vesicle endocytosis
C0048489biological_processsynaptic vesicle transport
C0050729biological_processpositive regulation of inflammatory response
C0050806biological_processpositive regulation of synaptic transmission
C0050808biological_processsynapse organization
C0050812biological_processregulation of acyl-CoA biosynthetic process
C0051219molecular_functionphosphoprotein binding
C0051259biological_processprotein complex oligomerization
C0051262biological_processprotein tetramerization
C0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
C0051402biological_processneuron apoptotic process
C0051583biological_processdopamine uptake involved in synaptic transmission
C0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
C0051612biological_processnegative regulation of serotonin uptake
C0051621biological_processregulation of norepinephrine uptake
C0051622biological_processnegative regulation of norepinephrine uptake
C0055074biological_processcalcium ion homeostasis
C0060079biological_processexcitatory postsynaptic potential
C0060090molecular_functionmolecular adaptor activity
C0060291biological_processlong-term synaptic potentiation
C0060732biological_processpositive regulation of inositol phosphate biosynthetic process
C0060961molecular_functionphospholipase D inhibitor activity
C0061024biological_processmembrane organization
C0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
C0070555biological_processresponse to interleukin-1
C0070840molecular_functiondynein complex binding
C0071280biological_processcellular response to copper ion
C0071872biological_processcellular response to epinephrine stimulus
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0097435biological_processsupramolecular fiber organization
C0098794cellular_componentpostsynapse
C0099512cellular_componentsupramolecular fiber
C1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
C1903136molecular_functioncuprous ion binding
C1903284biological_processpositive regulation of glutathione peroxidase activity
C1903285biological_processpositive regulation of hydrogen peroxide catabolic process
C1903421biological_processregulation of synaptic vesicle recycling
C1903426biological_processregulation of reactive oxygen species biosynthetic process
C1904377biological_processpositive regulation of protein localization to cell periphery
C1904715biological_processnegative regulation of chaperone-mediated autophagy
C1905606biological_processregulation of presynapse assembly
C1990000biological_processamyloid fibril formation
C2000377biological_processregulation of reactive oxygen species metabolic process
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000149molecular_functionSNARE binding
D0000287molecular_functionmagnesium ion binding
D0000976molecular_functiontranscription cis-regulatory region binding
D0001774biological_processmicroglial cell activation
D0001921biological_processpositive regulation of receptor recycling
D0001956biological_processpositive regulation of neurotransmitter secretion
D0001963biological_processsynaptic transmission, dopaminergic
D0003779molecular_functionactin binding
D0004860molecular_functionprotein kinase inhibitor activity
D0005504molecular_functionfatty acid binding
D0005507molecular_functioncopper ion binding
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005543molecular_functionphospholipid binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005764cellular_componentlysosome
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005886cellular_componentplasma membrane
D0005938cellular_componentcell cortex
D0006469biological_processnegative regulation of protein kinase activity
D0006631biological_processfatty acid metabolic process
D0006638biological_processneutral lipid metabolic process
D0006644biological_processphospholipid metabolic process
D0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
D0007006biological_processmitochondrial membrane organization
D0007268biological_processchemical synaptic transmission
D0007269biological_processneurotransmitter secretion
D0008198molecular_functionferrous iron binding
D0008270molecular_functionzinc ion binding
D0008289molecular_functionlipid binding
D0008344biological_processadult locomotory behavior
D0009410biological_processresponse to xenobiotic stimulus
D0010040biological_processresponse to iron(II) ion
D0010517biological_processregulation of phospholipase activity
D0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
D0014048biological_processregulation of glutamate secretion
D0014059biological_processregulation of dopamine secretion
D0015629cellular_componentactin cytoskeleton
D0016020cellular_componentmembrane
D0016079biological_processsynaptic vesicle exocytosis
D0016082biological_processsynaptic vesicle priming
D0016234cellular_componentinclusion body
D0016491molecular_functionoxidoreductase activity
D0019894molecular_functionkinesin binding
D0022898biological_processregulation of transmembrane transporter activity
D0030424cellular_componentaxon
D0030426cellular_componentgrowth cone
D0030544molecular_functionHsp70 protein binding
D0030672cellular_componentsynaptic vesicle membrane
D0031092cellular_componentplatelet alpha granule membrane
D0031115biological_processnegative regulation of microtubule polymerization
D0031623biological_processreceptor internalization
D0031648biological_processprotein destabilization
D0032026biological_processresponse to magnesium ion
D0032410biological_processnegative regulation of transporter activity
D0032496biological_processresponse to lipopolysaccharide
D0032769biological_processnegative regulation of monooxygenase activity
D0032991cellular_componentprotein-containing complex
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0034341biological_processresponse to type II interferon
D0034599biological_processcellular response to oxidative stress
D0035493biological_processSNARE complex assembly
D0035543biological_processpositive regulation of SNARE complex assembly
D0040012biological_processregulation of locomotion
D0042393molecular_functionhistone binding
D0042416biological_processdopamine biosynthetic process
D0042417biological_processdopamine metabolic process
D0042775biological_processmitochondrial ATP synthesis coupled electron transport
D0042802molecular_functionidentical protein binding
D0042995cellular_componentcell projection
D0043014molecular_functionalpha-tubulin binding
D0043025cellular_componentneuronal cell body
D0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
D0043030biological_processregulation of macrophage activation
D0043065biological_processpositive regulation of apoptotic process
D0043066biological_processnegative regulation of apoptotic process
D0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
D0043524biological_processnegative regulation of neuron apoptotic process
D0043679cellular_componentaxon terminus
D0045202cellular_componentsynapse
D0045807biological_processpositive regulation of endocytosis
D0045920biological_processnegative regulation of exocytosis
D0045921biological_processpositive regulation of exocytosis
D0046872molecular_functionmetal ion binding
D0046928biological_processregulation of neurotransmitter secretion
D0048156molecular_functiontau protein binding
D0048168biological_processregulation of neuronal synaptic plasticity
D0048169biological_processregulation of long-term neuronal synaptic plasticity
D0048471cellular_componentperinuclear region of cytoplasm
D0048488biological_processsynaptic vesicle endocytosis
D0048489biological_processsynaptic vesicle transport
D0050729biological_processpositive regulation of inflammatory response
D0050806biological_processpositive regulation of synaptic transmission
D0050808biological_processsynapse organization
D0050812biological_processregulation of acyl-CoA biosynthetic process
D0051219molecular_functionphosphoprotein binding
D0051259biological_processprotein complex oligomerization
D0051262biological_processprotein tetramerization
D0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
D0051402biological_processneuron apoptotic process
D0051583biological_processdopamine uptake involved in synaptic transmission
D0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
D0051612biological_processnegative regulation of serotonin uptake
D0051621biological_processregulation of norepinephrine uptake
D0051622biological_processnegative regulation of norepinephrine uptake
D0055074biological_processcalcium ion homeostasis
D0060079biological_processexcitatory postsynaptic potential
D0060090molecular_functionmolecular adaptor activity
D0060291biological_processlong-term synaptic potentiation
D0060732biological_processpositive regulation of inositol phosphate biosynthetic process
D0060961molecular_functionphospholipase D inhibitor activity
D0061024biological_processmembrane organization
D0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
D0070555biological_processresponse to interleukin-1
D0070840molecular_functiondynein complex binding
D0071280biological_processcellular response to copper ion
D0071872biological_processcellular response to epinephrine stimulus
D0071902biological_processpositive regulation of protein serine/threonine kinase activity
D0097435biological_processsupramolecular fiber organization
D0098794cellular_componentpostsynapse
D0099512cellular_componentsupramolecular fiber
D1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
D1903136molecular_functioncuprous ion binding
D1903284biological_processpositive regulation of glutathione peroxidase activity
D1903285biological_processpositive regulation of hydrogen peroxide catabolic process
D1903421biological_processregulation of synaptic vesicle recycling
D1903426biological_processregulation of reactive oxygen species biosynthetic process
D1904377biological_processpositive regulation of protein localization to cell periphery
D1904715biological_processnegative regulation of chaperone-mediated autophagy
D1905606biological_processregulation of presynapse assembly
D1990000biological_processamyloid fibril formation
D2000377biological_processregulation of reactive oxygen species metabolic process
E0000122biological_processnegative regulation of transcription by RNA polymerase II
E0000149molecular_functionSNARE binding
E0000287molecular_functionmagnesium ion binding
E0000976molecular_functiontranscription cis-regulatory region binding
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E0051262biological_processprotein tetramerization
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E0051402biological_processneuron apoptotic process
E0051583biological_processdopamine uptake involved in synaptic transmission
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E0051612biological_processnegative regulation of serotonin uptake
E0051621biological_processregulation of norepinephrine uptake
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E0055074biological_processcalcium ion homeostasis
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E0071280biological_processcellular response to copper ion
E0071872biological_processcellular response to epinephrine stimulus
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E0098794cellular_componentpostsynapse
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F0051262biological_processprotein tetramerization
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F0051402biological_processneuron apoptotic process
F0051583biological_processdopamine uptake involved in synaptic transmission
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F0051612biological_processnegative regulation of serotonin uptake
F0051621biological_processregulation of norepinephrine uptake
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F0055074biological_processcalcium ion homeostasis
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F0070555biological_processresponse to interleukin-1
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F0071280biological_processcellular response to copper ion
F0071872biological_processcellular response to epinephrine stimulus
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F1903426biological_processregulation of reactive oxygen species biosynthetic process
F1904377biological_processpositive regulation of protein localization to cell periphery
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F1905606biological_processregulation of presynapse assembly
F1990000biological_processamyloid fibril formation
F2000377biological_processregulation of reactive oxygen species metabolic process
I0000122biological_processnegative regulation of transcription by RNA polymerase II
I0000149molecular_functionSNARE binding
I0000287molecular_functionmagnesium ion binding
I0000976molecular_functiontranscription cis-regulatory region binding
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I0001956biological_processpositive regulation of neurotransmitter secretion
I0001963biological_processsynaptic transmission, dopaminergic
I0003779molecular_functionactin binding
I0004860molecular_functionprotein kinase inhibitor activity
I0005504molecular_functionfatty acid binding
I0005507molecular_functioncopper ion binding
I0005509molecular_functioncalcium ion binding
I0005515molecular_functionprotein binding
I0005543molecular_functionphospholipid binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005739cellular_componentmitochondrion
I0005764cellular_componentlysosome
I0005829cellular_componentcytosol
I0005856cellular_componentcytoskeleton
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I0006644biological_processphospholipid metabolic process
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I0007006biological_processmitochondrial membrane organization
I0007268biological_processchemical synaptic transmission
I0007269biological_processneurotransmitter secretion
I0008198molecular_functionferrous iron binding
I0008270molecular_functionzinc ion binding
I0008289molecular_functionlipid binding
I0008344biological_processadult locomotory behavior
I0009410biological_processresponse to xenobiotic stimulus
I0010040biological_processresponse to iron(II) ion
I0010517biological_processregulation of phospholipase activity
I0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
I0014048biological_processregulation of glutamate secretion
I0014059biological_processregulation of dopamine secretion
I0015629cellular_componentactin cytoskeleton
I0016020cellular_componentmembrane
I0016079biological_processsynaptic vesicle exocytosis
I0016082biological_processsynaptic vesicle priming
I0016234cellular_componentinclusion body
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I0019894molecular_functionkinesin binding
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I0030424cellular_componentaxon
I0030426cellular_componentgrowth cone
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I0030672cellular_componentsynaptic vesicle membrane
I0031092cellular_componentplatelet alpha granule membrane
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I0031623biological_processreceptor internalization
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I0032026biological_processresponse to magnesium ion
I0032410biological_processnegative regulation of transporter activity
I0032496biological_processresponse to lipopolysaccharide
I0032769biological_processnegative regulation of monooxygenase activity
I0032991cellular_componentprotein-containing complex
I0033138biological_processpositive regulation of peptidyl-serine phosphorylation
I0034341biological_processresponse to type II interferon
I0034599biological_processcellular response to oxidative stress
I0035493biological_processSNARE complex assembly
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I0040012biological_processregulation of locomotion
I0042393molecular_functionhistone binding
I0042416biological_processdopamine biosynthetic process
I0042417biological_processdopamine metabolic process
I0042775biological_processmitochondrial ATP synthesis coupled electron transport
I0042802molecular_functionidentical protein binding
I0042995cellular_componentcell projection
I0043014molecular_functionalpha-tubulin binding
I0043025cellular_componentneuronal cell body
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I0043030biological_processregulation of macrophage activation
I0043065biological_processpositive regulation of apoptotic process
I0043066biological_processnegative regulation of apoptotic process
I0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
I0043524biological_processnegative regulation of neuron apoptotic process
I0043679cellular_componentaxon terminus
I0045202cellular_componentsynapse
I0045807biological_processpositive regulation of endocytosis
I0045920biological_processnegative regulation of exocytosis
I0045921biological_processpositive regulation of exocytosis
I0046872molecular_functionmetal ion binding
I0046928biological_processregulation of neurotransmitter secretion
I0048156molecular_functiontau protein binding
I0048168biological_processregulation of neuronal synaptic plasticity
I0048169biological_processregulation of long-term neuronal synaptic plasticity
I0048471cellular_componentperinuclear region of cytoplasm
I0048488biological_processsynaptic vesicle endocytosis
I0048489biological_processsynaptic vesicle transport
I0050729biological_processpositive regulation of inflammatory response
I0050806biological_processpositive regulation of synaptic transmission
I0050808biological_processsynapse organization
I0050812biological_processregulation of acyl-CoA biosynthetic process
I0051219molecular_functionphosphoprotein binding
I0051259biological_processprotein complex oligomerization
I0051262biological_processprotein tetramerization
I0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
I0051402biological_processneuron apoptotic process
I0051583biological_processdopamine uptake involved in synaptic transmission
I0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
I0051612biological_processnegative regulation of serotonin uptake
I0051621biological_processregulation of norepinephrine uptake
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I0055074biological_processcalcium ion homeostasis
I0060079biological_processexcitatory postsynaptic potential
I0060090molecular_functionmolecular adaptor activity
I0060291biological_processlong-term synaptic potentiation
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I0060961molecular_functionphospholipase D inhibitor activity
I0061024biological_processmembrane organization
I0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
I0070555biological_processresponse to interleukin-1
I0070840molecular_functiondynein complex binding
I0071280biological_processcellular response to copper ion
I0071872biological_processcellular response to epinephrine stimulus
I0071902biological_processpositive regulation of protein serine/threonine kinase activity
I0097435biological_processsupramolecular fiber organization
I0098794cellular_componentpostsynapse
I0099512cellular_componentsupramolecular fiber
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I1903136molecular_functioncuprous ion binding
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I1903285biological_processpositive regulation of hydrogen peroxide catabolic process
I1903421biological_processregulation of synaptic vesicle recycling
I1903426biological_processregulation of reactive oxygen species biosynthetic process
I1904377biological_processpositive regulation of protein localization to cell periphery
I1904715biological_processnegative regulation of chaperone-mediated autophagy
I1905606biological_processregulation of presynapse assembly
I1990000biological_processamyloid fibril formation
I2000377biological_processregulation of reactive oxygen species metabolic process
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J0000149molecular_functionSNARE binding
J0000287molecular_functionmagnesium ion binding
J0000976molecular_functiontranscription cis-regulatory region binding
J0001774biological_processmicroglial cell activation
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J0001956biological_processpositive regulation of neurotransmitter secretion
J0001963biological_processsynaptic transmission, dopaminergic
J0003779molecular_functionactin binding
J0004860molecular_functionprotein kinase inhibitor activity
J0005504molecular_functionfatty acid binding
J0005507molecular_functioncopper ion binding
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005543molecular_functionphospholipid binding
J0005576cellular_componentextracellular region
J0005615cellular_componentextracellular space
J0005634cellular_componentnucleus
J0005737cellular_componentcytoplasm
J0005739cellular_componentmitochondrion
J0005764cellular_componentlysosome
J0005829cellular_componentcytosol
J0005856cellular_componentcytoskeleton
J0005886cellular_componentplasma membrane
J0005938cellular_componentcell cortex
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J0006631biological_processfatty acid metabolic process
J0006638biological_processneutral lipid metabolic process
J0006644biological_processphospholipid metabolic process
J0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
J0007006biological_processmitochondrial membrane organization
J0007268biological_processchemical synaptic transmission
J0007269biological_processneurotransmitter secretion
J0008198molecular_functionferrous iron binding
J0008270molecular_functionzinc ion binding
J0008289molecular_functionlipid binding
J0008344biological_processadult locomotory behavior
J0009410biological_processresponse to xenobiotic stimulus
J0010040biological_processresponse to iron(II) ion
J0010517biological_processregulation of phospholipase activity
J0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
J0014048biological_processregulation of glutamate secretion
J0014059biological_processregulation of dopamine secretion
J0015629cellular_componentactin cytoskeleton
J0016020cellular_componentmembrane
J0016079biological_processsynaptic vesicle exocytosis
J0016082biological_processsynaptic vesicle priming
J0016234cellular_componentinclusion body
J0016491molecular_functionoxidoreductase activity
J0019894molecular_functionkinesin binding
J0022898biological_processregulation of transmembrane transporter activity
J0030424cellular_componentaxon
J0030426cellular_componentgrowth cone
J0030544molecular_functionHsp70 protein binding
J0030672cellular_componentsynaptic vesicle membrane
J0031092cellular_componentplatelet alpha granule membrane
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J0031623biological_processreceptor internalization
J0031648biological_processprotein destabilization
J0032026biological_processresponse to magnesium ion
J0032410biological_processnegative regulation of transporter activity
J0032496biological_processresponse to lipopolysaccharide
J0032769biological_processnegative regulation of monooxygenase activity
J0032991cellular_componentprotein-containing complex
J0033138biological_processpositive regulation of peptidyl-serine phosphorylation
J0034341biological_processresponse to type II interferon
J0034599biological_processcellular response to oxidative stress
J0035493biological_processSNARE complex assembly
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J0040012biological_processregulation of locomotion
J0042393molecular_functionhistone binding
J0042416biological_processdopamine biosynthetic process
J0042417biological_processdopamine metabolic process
J0042775biological_processmitochondrial ATP synthesis coupled electron transport
J0042802molecular_functionidentical protein binding
J0042995cellular_componentcell projection
J0043014molecular_functionalpha-tubulin binding
J0043025cellular_componentneuronal cell body
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J0043065biological_processpositive regulation of apoptotic process
J0043066biological_processnegative regulation of apoptotic process
J0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
J0043524biological_processnegative regulation of neuron apoptotic process
J0043679cellular_componentaxon terminus
J0045202cellular_componentsynapse
J0045807biological_processpositive regulation of endocytosis
J0045920biological_processnegative regulation of exocytosis
J0045921biological_processpositive regulation of exocytosis
J0046872molecular_functionmetal ion binding
J0046928biological_processregulation of neurotransmitter secretion
J0048156molecular_functiontau protein binding
J0048168biological_processregulation of neuronal synaptic plasticity
J0048169biological_processregulation of long-term neuronal synaptic plasticity
J0048471cellular_componentperinuclear region of cytoplasm
J0048488biological_processsynaptic vesicle endocytosis
J0048489biological_processsynaptic vesicle transport
J0050729biological_processpositive regulation of inflammatory response
J0050806biological_processpositive regulation of synaptic transmission
J0050808biological_processsynapse organization
J0050812biological_processregulation of acyl-CoA biosynthetic process
J0051219molecular_functionphosphoprotein binding
J0051259biological_processprotein complex oligomerization
J0051262biological_processprotein tetramerization
J0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
J0051402biological_processneuron apoptotic process
J0051583biological_processdopamine uptake involved in synaptic transmission
J0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
J0051612biological_processnegative regulation of serotonin uptake
J0051621biological_processregulation of norepinephrine uptake
J0051622biological_processnegative regulation of norepinephrine uptake
J0055074biological_processcalcium ion homeostasis
J0060079biological_processexcitatory postsynaptic potential
J0060090molecular_functionmolecular adaptor activity
J0060291biological_processlong-term synaptic potentiation
J0060732biological_processpositive regulation of inositol phosphate biosynthetic process
J0060961molecular_functionphospholipase D inhibitor activity
J0061024biological_processmembrane organization
J0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
J0070555biological_processresponse to interleukin-1
J0070840molecular_functiondynein complex binding
J0071280biological_processcellular response to copper ion
J0071872biological_processcellular response to epinephrine stimulus
J0071902biological_processpositive regulation of protein serine/threonine kinase activity
J0097435biological_processsupramolecular fiber organization
J0098794cellular_componentpostsynapse
J0099512cellular_componentsupramolecular fiber
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J1903285biological_processpositive regulation of hydrogen peroxide catabolic process
J1903421biological_processregulation of synaptic vesicle recycling
J1903426biological_processregulation of reactive oxygen species biosynthetic process
J1904377biological_processpositive regulation of protein localization to cell periphery
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J1905606biological_processregulation of presynapse assembly
J1990000biological_processamyloid fibril formation
J2000377biological_processregulation of reactive oxygen species metabolic process
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K0001956biological_processpositive regulation of neurotransmitter secretion
K0001963biological_processsynaptic transmission, dopaminergic
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K0004860molecular_functionprotein kinase inhibitor activity
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K0005507molecular_functioncopper ion binding
K0005509molecular_functioncalcium ion binding
K0005515molecular_functionprotein binding
K0005543molecular_functionphospholipid binding
K0005576cellular_componentextracellular region
K0005615cellular_componentextracellular space
K0005634cellular_componentnucleus
K0005737cellular_componentcytoplasm
K0005739cellular_componentmitochondrion
K0005764cellular_componentlysosome
K0005829cellular_componentcytosol
K0005856cellular_componentcytoskeleton
K0005886cellular_componentplasma membrane
K0005938cellular_componentcell cortex
K0006469biological_processnegative regulation of protein kinase activity
K0006631biological_processfatty acid metabolic process
K0006638biological_processneutral lipid metabolic process
K0006644biological_processphospholipid metabolic process
K0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
K0007006biological_processmitochondrial membrane organization
K0007268biological_processchemical synaptic transmission
K0007269biological_processneurotransmitter secretion
K0008198molecular_functionferrous iron binding
K0008270molecular_functionzinc ion binding
K0008289molecular_functionlipid binding
K0008344biological_processadult locomotory behavior
K0009410biological_processresponse to xenobiotic stimulus
K0010040biological_processresponse to iron(II) ion
K0010517biological_processregulation of phospholipase activity
K0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
K0014048biological_processregulation of glutamate secretion
K0014059biological_processregulation of dopamine secretion
K0015629cellular_componentactin cytoskeleton
K0016020cellular_componentmembrane
K0016079biological_processsynaptic vesicle exocytosis
K0016082biological_processsynaptic vesicle priming
K0016234cellular_componentinclusion body
K0016491molecular_functionoxidoreductase activity
K0019894molecular_functionkinesin binding
K0022898biological_processregulation of transmembrane transporter activity
K0030424cellular_componentaxon
K0030426cellular_componentgrowth cone
K0030544molecular_functionHsp70 protein binding
K0030672cellular_componentsynaptic vesicle membrane
K0031092cellular_componentplatelet alpha granule membrane
K0031115biological_processnegative regulation of microtubule polymerization
K0031623biological_processreceptor internalization
K0031648biological_processprotein destabilization
K0032026biological_processresponse to magnesium ion
K0032410biological_processnegative regulation of transporter activity
K0032496biological_processresponse to lipopolysaccharide
K0032769biological_processnegative regulation of monooxygenase activity
K0032991cellular_componentprotein-containing complex
K0033138biological_processpositive regulation of peptidyl-serine phosphorylation
K0034341biological_processresponse to type II interferon
K0034599biological_processcellular response to oxidative stress
K0035493biological_processSNARE complex assembly
K0035543biological_processpositive regulation of SNARE complex assembly
K0040012biological_processregulation of locomotion
K0042393molecular_functionhistone binding
K0042416biological_processdopamine biosynthetic process
K0042417biological_processdopamine metabolic process
K0042775biological_processmitochondrial ATP synthesis coupled electron transport
K0042802molecular_functionidentical protein binding
K0042995cellular_componentcell projection
K0043014molecular_functionalpha-tubulin binding
K0043025cellular_componentneuronal cell body
K0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
K0043030biological_processregulation of macrophage activation
K0043065biological_processpositive regulation of apoptotic process
K0043066biological_processnegative regulation of apoptotic process
K0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
K0043524biological_processnegative regulation of neuron apoptotic process
K0043679cellular_componentaxon terminus
K0045202cellular_componentsynapse
K0045807biological_processpositive regulation of endocytosis
K0045920biological_processnegative regulation of exocytosis
K0045921biological_processpositive regulation of exocytosis
K0046872molecular_functionmetal ion binding
K0046928biological_processregulation of neurotransmitter secretion
K0048156molecular_functiontau protein binding
K0048168biological_processregulation of neuronal synaptic plasticity
K0048169biological_processregulation of long-term neuronal synaptic plasticity
K0048471cellular_componentperinuclear region of cytoplasm
K0048488biological_processsynaptic vesicle endocytosis
K0048489biological_processsynaptic vesicle transport
K0050729biological_processpositive regulation of inflammatory response
K0050806biological_processpositive regulation of synaptic transmission
K0050808biological_processsynapse organization
K0050812biological_processregulation of acyl-CoA biosynthetic process
K0051219molecular_functionphosphoprotein binding
K0051259biological_processprotein complex oligomerization
K0051262biological_processprotein tetramerization
K0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
K0051402biological_processneuron apoptotic process
K0051583biological_processdopamine uptake involved in synaptic transmission
K0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
K0051612biological_processnegative regulation of serotonin uptake
K0051621biological_processregulation of norepinephrine uptake
K0051622biological_processnegative regulation of norepinephrine uptake
K0055074biological_processcalcium ion homeostasis
K0060079biological_processexcitatory postsynaptic potential
K0060090molecular_functionmolecular adaptor activity
K0060291biological_processlong-term synaptic potentiation
K0060732biological_processpositive regulation of inositol phosphate biosynthetic process
K0060961molecular_functionphospholipase D inhibitor activity
K0061024biological_processmembrane organization
K0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
K0070555biological_processresponse to interleukin-1
K0070840molecular_functiondynein complex binding
K0071280biological_processcellular response to copper ion
K0071872biological_processcellular response to epinephrine stimulus
K0071902biological_processpositive regulation of protein serine/threonine kinase activity
K0097435biological_processsupramolecular fiber organization
K0098794cellular_componentpostsynapse
K0099512cellular_componentsupramolecular fiber
K1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
K1903136molecular_functioncuprous ion binding
K1903284biological_processpositive regulation of glutathione peroxidase activity
K1903285biological_processpositive regulation of hydrogen peroxide catabolic process
K1903421biological_processregulation of synaptic vesicle recycling
K1903426biological_processregulation of reactive oxygen species biosynthetic process
K1904377biological_processpositive regulation of protein localization to cell periphery
K1904715biological_processnegative regulation of chaperone-mediated autophagy
K1905606biological_processregulation of presynapse assembly
K1990000biological_processamyloid fibril formation
K2000377biological_processregulation of reactive oxygen species metabolic process
L0000122biological_processnegative regulation of transcription by RNA polymerase II
L0000149molecular_functionSNARE binding
L0000287molecular_functionmagnesium ion binding
L0000976molecular_functiontranscription cis-regulatory region binding
L0001774biological_processmicroglial cell activation
L0001921biological_processpositive regulation of receptor recycling
L0001956biological_processpositive regulation of neurotransmitter secretion
L0001963biological_processsynaptic transmission, dopaminergic
L0003779molecular_functionactin binding
L0004860molecular_functionprotein kinase inhibitor activity
L0005504molecular_functionfatty acid binding
L0005507molecular_functioncopper ion binding
L0005509molecular_functioncalcium ion binding
L0005515molecular_functionprotein binding
L0005543molecular_functionphospholipid binding
L0005576cellular_componentextracellular region
L0005615cellular_componentextracellular space
L0005634cellular_componentnucleus
L0005737cellular_componentcytoplasm
L0005739cellular_componentmitochondrion
L0005764cellular_componentlysosome
L0005829cellular_componentcytosol
L0005856cellular_componentcytoskeleton
L0005886cellular_componentplasma membrane
L0005938cellular_componentcell cortex
L0006469biological_processnegative regulation of protein kinase activity
L0006631biological_processfatty acid metabolic process
L0006638biological_processneutral lipid metabolic process
L0006644biological_processphospholipid metabolic process
L0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
L0007006biological_processmitochondrial membrane organization
L0007268biological_processchemical synaptic transmission
L0007269biological_processneurotransmitter secretion
L0008198molecular_functionferrous iron binding
L0008270molecular_functionzinc ion binding
L0008289molecular_functionlipid binding
L0008344biological_processadult locomotory behavior
L0009410biological_processresponse to xenobiotic stimulus
L0010040biological_processresponse to iron(II) ion
L0010517biological_processregulation of phospholipase activity
L0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
L0014048biological_processregulation of glutamate secretion
L0014059biological_processregulation of dopamine secretion
L0015629cellular_componentactin cytoskeleton
L0016020cellular_componentmembrane
L0016079biological_processsynaptic vesicle exocytosis
L0016082biological_processsynaptic vesicle priming
L0016234cellular_componentinclusion body
L0016491molecular_functionoxidoreductase activity
L0019894molecular_functionkinesin binding
L0022898biological_processregulation of transmembrane transporter activity
L0030424cellular_componentaxon
L0030426cellular_componentgrowth cone
L0030544molecular_functionHsp70 protein binding
L0030672cellular_componentsynaptic vesicle membrane
L0031092cellular_componentplatelet alpha granule membrane
L0031115biological_processnegative regulation of microtubule polymerization
L0031623biological_processreceptor internalization
L0031648biological_processprotein destabilization
L0032026biological_processresponse to magnesium ion
L0032410biological_processnegative regulation of transporter activity
L0032496biological_processresponse to lipopolysaccharide
L0032769biological_processnegative regulation of monooxygenase activity
L0032991cellular_componentprotein-containing complex
L0033138biological_processpositive regulation of peptidyl-serine phosphorylation
L0034341biological_processresponse to type II interferon
L0034599biological_processcellular response to oxidative stress
L0035493biological_processSNARE complex assembly
L0035543biological_processpositive regulation of SNARE complex assembly
L0040012biological_processregulation of locomotion
L0042393molecular_functionhistone binding
L0042416biological_processdopamine biosynthetic process
L0042417biological_processdopamine metabolic process
L0042775biological_processmitochondrial ATP synthesis coupled electron transport
L0042802molecular_functionidentical protein binding
L0042995cellular_componentcell projection
L0043014molecular_functionalpha-tubulin binding
L0043025cellular_componentneuronal cell body
L0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
L0043030biological_processregulation of macrophage activation
L0043065biological_processpositive regulation of apoptotic process
L0043066biological_processnegative regulation of apoptotic process
L0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
L0043524biological_processnegative regulation of neuron apoptotic process
L0043679cellular_componentaxon terminus
L0045202cellular_componentsynapse
L0045807biological_processpositive regulation of endocytosis
L0045920biological_processnegative regulation of exocytosis
L0045921biological_processpositive regulation of exocytosis
L0046872molecular_functionmetal ion binding
L0046928biological_processregulation of neurotransmitter secretion
L0048156molecular_functiontau protein binding
L0048168biological_processregulation of neuronal synaptic plasticity
L0048169biological_processregulation of long-term neuronal synaptic plasticity
L0048471cellular_componentperinuclear region of cytoplasm
L0048488biological_processsynaptic vesicle endocytosis
L0048489biological_processsynaptic vesicle transport
L0050729biological_processpositive regulation of inflammatory response
L0050806biological_processpositive regulation of synaptic transmission
L0050808biological_processsynapse organization
L0050812biological_processregulation of acyl-CoA biosynthetic process
L0051219molecular_functionphosphoprotein binding
L0051259biological_processprotein complex oligomerization
L0051262biological_processprotein tetramerization
L0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
L0051402biological_processneuron apoptotic process
L0051583biological_processdopamine uptake involved in synaptic transmission
L0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
L0051612biological_processnegative regulation of serotonin uptake
L0051621biological_processregulation of norepinephrine uptake
L0051622biological_processnegative regulation of norepinephrine uptake
L0055074biological_processcalcium ion homeostasis
L0060079biological_processexcitatory postsynaptic potential
L0060090molecular_functionmolecular adaptor activity
L0060291biological_processlong-term synaptic potentiation
L0060732biological_processpositive regulation of inositol phosphate biosynthetic process
L0060961molecular_functionphospholipase D inhibitor activity
L0061024biological_processmembrane organization
L0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
L0070555biological_processresponse to interleukin-1
L0070840molecular_functiondynein complex binding
L0071280biological_processcellular response to copper ion
L0071872biological_processcellular response to epinephrine stimulus
L0071902biological_processpositive regulation of protein serine/threonine kinase activity
L0097435biological_processsupramolecular fiber organization
L0098794cellular_componentpostsynapse
L0099512cellular_componentsupramolecular fiber
L1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
L1903136molecular_functioncuprous ion binding
L1903284biological_processpositive regulation of glutathione peroxidase activity
L1903285biological_processpositive regulation of hydrogen peroxide catabolic process
L1903421biological_processregulation of synaptic vesicle recycling
L1903426biological_processregulation of reactive oxygen species biosynthetic process
L1904377biological_processpositive regulation of protein localization to cell periphery
L1904715biological_processnegative regulation of chaperone-mediated autophagy
L1905606biological_processregulation of presynapse assembly
L1990000biological_processamyloid fibril formation
L2000377biological_processregulation of reactive oxygen species metabolic process
M0000122biological_processnegative regulation of transcription by RNA polymerase II
M0000149molecular_functionSNARE binding
M0000287molecular_functionmagnesium ion binding
M0000976molecular_functiontranscription cis-regulatory region binding
M0001774biological_processmicroglial cell activation
M0001921biological_processpositive regulation of receptor recycling
M0001956biological_processpositive regulation of neurotransmitter secretion
M0001963biological_processsynaptic transmission, dopaminergic
M0003779molecular_functionactin binding
M0004860molecular_functionprotein kinase inhibitor activity
M0005504molecular_functionfatty acid binding
M0005507molecular_functioncopper ion binding
M0005509molecular_functioncalcium ion binding
M0005515molecular_functionprotein binding
M0005543molecular_functionphospholipid binding
M0005576cellular_componentextracellular region
M0005615cellular_componentextracellular space
M0005634cellular_componentnucleus
M0005737cellular_componentcytoplasm
M0005739cellular_componentmitochondrion
M0005764cellular_componentlysosome
M0005829cellular_componentcytosol
M0005856cellular_componentcytoskeleton
M0005886cellular_componentplasma membrane
M0005938cellular_componentcell cortex
M0006469biological_processnegative regulation of protein kinase activity
M0006631biological_processfatty acid metabolic process
M0006638biological_processneutral lipid metabolic process
M0006644biological_processphospholipid metabolic process
M0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
M0007006biological_processmitochondrial membrane organization
M0007268biological_processchemical synaptic transmission
M0007269biological_processneurotransmitter secretion
M0008198molecular_functionferrous iron binding
M0008270molecular_functionzinc ion binding
M0008289molecular_functionlipid binding
M0008344biological_processadult locomotory behavior
M0009410biological_processresponse to xenobiotic stimulus
M0010040biological_processresponse to iron(II) ion
M0010517biological_processregulation of phospholipase activity
M0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
M0014048biological_processregulation of glutamate secretion
M0014059biological_processregulation of dopamine secretion
M0015629cellular_componentactin cytoskeleton
M0016020cellular_componentmembrane
M0016079biological_processsynaptic vesicle exocytosis
M0016082biological_processsynaptic vesicle priming
M0016234cellular_componentinclusion body
M0016491molecular_functionoxidoreductase activity
M0019894molecular_functionkinesin binding
M0022898biological_processregulation of transmembrane transporter activity
M0030424cellular_componentaxon
M0030426cellular_componentgrowth cone
M0030544molecular_functionHsp70 protein binding
M0030672cellular_componentsynaptic vesicle membrane
M0031092cellular_componentplatelet alpha granule membrane
M0031115biological_processnegative regulation of microtubule polymerization
M0031623biological_processreceptor internalization
M0031648biological_processprotein destabilization
M0032026biological_processresponse to magnesium ion
M0032410biological_processnegative regulation of transporter activity
M0032496biological_processresponse to lipopolysaccharide
M0032769biological_processnegative regulation of monooxygenase activity
M0032991cellular_componentprotein-containing complex
M0033138biological_processpositive regulation of peptidyl-serine phosphorylation
M0034341biological_processresponse to type II interferon
M0034599biological_processcellular response to oxidative stress
M0035493biological_processSNARE complex assembly
M0035543biological_processpositive regulation of SNARE complex assembly
M0040012biological_processregulation of locomotion
M0042393molecular_functionhistone binding
M0042416biological_processdopamine biosynthetic process
M0042417biological_processdopamine metabolic process
M0042775biological_processmitochondrial ATP synthesis coupled electron transport
M0042802molecular_functionidentical protein binding
M0042995cellular_componentcell projection
M0043014molecular_functionalpha-tubulin binding
M0043025cellular_componentneuronal cell body
M0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
M0043030biological_processregulation of macrophage activation
M0043065biological_processpositive regulation of apoptotic process
M0043066biological_processnegative regulation of apoptotic process
M0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
M0043524biological_processnegative regulation of neuron apoptotic process
M0043679cellular_componentaxon terminus
M0045202cellular_componentsynapse
M0045807biological_processpositive regulation of endocytosis
M0045920biological_processnegative regulation of exocytosis
M0045921biological_processpositive regulation of exocytosis
M0046872molecular_functionmetal ion binding
M0046928biological_processregulation of neurotransmitter secretion
M0048156molecular_functiontau protein binding
M0048168biological_processregulation of neuronal synaptic plasticity
M0048169biological_processregulation of long-term neuronal synaptic plasticity
M0048471cellular_componentperinuclear region of cytoplasm
M0048488biological_processsynaptic vesicle endocytosis
M0048489biological_processsynaptic vesicle transport
M0050729biological_processpositive regulation of inflammatory response
M0050806biological_processpositive regulation of synaptic transmission
M0050808biological_processsynapse organization
M0050812biological_processregulation of acyl-CoA biosynthetic process
M0051219molecular_functionphosphoprotein binding
M0051259biological_processprotein complex oligomerization
M0051262biological_processprotein tetramerization
M0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
M0051402biological_processneuron apoptotic process
M0051583biological_processdopamine uptake involved in synaptic transmission
M0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
M0051612biological_processnegative regulation of serotonin uptake
M0051621biological_processregulation of norepinephrine uptake
M0051622biological_processnegative regulation of norepinephrine uptake
M0055074biological_processcalcium ion homeostasis
M0060079biological_processexcitatory postsynaptic potential
M0060090molecular_functionmolecular adaptor activity
M0060291biological_processlong-term synaptic potentiation
M0060732biological_processpositive regulation of inositol phosphate biosynthetic process
M0060961molecular_functionphospholipase D inhibitor activity
M0061024biological_processmembrane organization
M0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
M0070555biological_processresponse to interleukin-1
M0070840molecular_functiondynein complex binding
M0071280biological_processcellular response to copper ion
M0071872biological_processcellular response to epinephrine stimulus
M0071902biological_processpositive regulation of protein serine/threonine kinase activity
M0097435biological_processsupramolecular fiber organization
M0098794cellular_componentpostsynapse
M0099512cellular_componentsupramolecular fiber
M1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
M1903136molecular_functioncuprous ion binding
M1903284biological_processpositive regulation of glutathione peroxidase activity
M1903285biological_processpositive regulation of hydrogen peroxide catabolic process
M1903421biological_processregulation of synaptic vesicle recycling
M1903426biological_processregulation of reactive oxygen species biosynthetic process
M1904377biological_processpositive regulation of protein localization to cell periphery
M1904715biological_processnegative regulation of chaperone-mediated autophagy
M1905606biological_processregulation of presynapse assembly
M1990000biological_processamyloid fibril formation
M2000377biological_processregulation of reactive oxygen species metabolic process
N0000122biological_processnegative regulation of transcription by RNA polymerase II
N0000149molecular_functionSNARE binding
N0000287molecular_functionmagnesium ion binding
N0000976molecular_functiontranscription cis-regulatory region binding
N0001774biological_processmicroglial cell activation
N0001921biological_processpositive regulation of receptor recycling
N0001956biological_processpositive regulation of neurotransmitter secretion
N0001963biological_processsynaptic transmission, dopaminergic
N0003779molecular_functionactin binding
N0004860molecular_functionprotein kinase inhibitor activity
N0005504molecular_functionfatty acid binding
N0005507molecular_functioncopper ion binding
N0005509molecular_functioncalcium ion binding
N0005515molecular_functionprotein binding
N0005543molecular_functionphospholipid binding
N0005576cellular_componentextracellular region
N0005615cellular_componentextracellular space
N0005634cellular_componentnucleus
N0005737cellular_componentcytoplasm
N0005739cellular_componentmitochondrion
N0005764cellular_componentlysosome
N0005829cellular_componentcytosol
N0005856cellular_componentcytoskeleton
N0005886cellular_componentplasma membrane
N0005938cellular_componentcell cortex
N0006469biological_processnegative regulation of protein kinase activity
N0006631biological_processfatty acid metabolic process
N0006638biological_processneutral lipid metabolic process
N0006644biological_processphospholipid metabolic process
N0006919biological_processactivation of cysteine-type endopeptidase activity involved in apoptotic process
N0007006biological_processmitochondrial membrane organization
N0007268biological_processchemical synaptic transmission
N0007269biological_processneurotransmitter secretion
N0008198molecular_functionferrous iron binding
N0008270molecular_functionzinc ion binding
N0008289molecular_functionlipid binding
N0008344biological_processadult locomotory behavior
N0009410biological_processresponse to xenobiotic stimulus
N0010040biological_processresponse to iron(II) ion
N0010517biological_processregulation of phospholipase activity
N0010642biological_processnegative regulation of platelet-derived growth factor receptor signaling pathway
N0014048biological_processregulation of glutamate secretion
N0014059biological_processregulation of dopamine secretion
N0015629cellular_componentactin cytoskeleton
N0016020cellular_componentmembrane
N0016079biological_processsynaptic vesicle exocytosis
N0016082biological_processsynaptic vesicle priming
N0016234cellular_componentinclusion body
N0016491molecular_functionoxidoreductase activity
N0019894molecular_functionkinesin binding
N0022898biological_processregulation of transmembrane transporter activity
N0030424cellular_componentaxon
N0030426cellular_componentgrowth cone
N0030544molecular_functionHsp70 protein binding
N0030672cellular_componentsynaptic vesicle membrane
N0031092cellular_componentplatelet alpha granule membrane
N0031115biological_processnegative regulation of microtubule polymerization
N0031623biological_processreceptor internalization
N0031648biological_processprotein destabilization
N0032026biological_processresponse to magnesium ion
N0032410biological_processnegative regulation of transporter activity
N0032496biological_processresponse to lipopolysaccharide
N0032769biological_processnegative regulation of monooxygenase activity
N0032991cellular_componentprotein-containing complex
N0033138biological_processpositive regulation of peptidyl-serine phosphorylation
N0034341biological_processresponse to type II interferon
N0034599biological_processcellular response to oxidative stress
N0035493biological_processSNARE complex assembly
N0035543biological_processpositive regulation of SNARE complex assembly
N0040012biological_processregulation of locomotion
N0042393molecular_functionhistone binding
N0042416biological_processdopamine biosynthetic process
N0042417biological_processdopamine metabolic process
N0042775biological_processmitochondrial ATP synthesis coupled electron transport
N0042802molecular_functionidentical protein binding
N0042995cellular_componentcell projection
N0043014molecular_functionalpha-tubulin binding
N0043025cellular_componentneuronal cell body
N0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
N0043030biological_processregulation of macrophage activation
N0043065biological_processpositive regulation of apoptotic process
N0043066biological_processnegative regulation of apoptotic process
N0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
N0043524biological_processnegative regulation of neuron apoptotic process
N0043679cellular_componentaxon terminus
N0045202cellular_componentsynapse
N0045807biological_processpositive regulation of endocytosis
N0045920biological_processnegative regulation of exocytosis
N0045921biological_processpositive regulation of exocytosis
N0046872molecular_functionmetal ion binding
N0046928biological_processregulation of neurotransmitter secretion
N0048156molecular_functiontau protein binding
N0048168biological_processregulation of neuronal synaptic plasticity
N0048169biological_processregulation of long-term neuronal synaptic plasticity
N0048471cellular_componentperinuclear region of cytoplasm
N0048488biological_processsynaptic vesicle endocytosis
N0048489biological_processsynaptic vesicle transport
N0050729biological_processpositive regulation of inflammatory response
N0050806biological_processpositive regulation of synaptic transmission
N0050808biological_processsynapse organization
N0050812biological_processregulation of acyl-CoA biosynthetic process
N0051219molecular_functionphosphoprotein binding
N0051259biological_processprotein complex oligomerization
N0051262biological_processprotein tetramerization
N0051281biological_processpositive regulation of release of sequestered calcium ion into cytosol
N0051402biological_processneuron apoptotic process
N0051583biological_processdopamine uptake involved in synaptic transmission
N0051585biological_processnegative regulation of dopamine uptake involved in synaptic transmission
N0051612biological_processnegative regulation of serotonin uptake
N0051621biological_processregulation of norepinephrine uptake
N0051622biological_processnegative regulation of norepinephrine uptake
N0055074biological_processcalcium ion homeostasis
N0060079biological_processexcitatory postsynaptic potential
N0060090molecular_functionmolecular adaptor activity
N0060291biological_processlong-term synaptic potentiation
N0060732biological_processpositive regulation of inositol phosphate biosynthetic process
N0060961molecular_functionphospholipase D inhibitor activity
N0061024biological_processmembrane organization
N0070495biological_processnegative regulation of thrombin-activated receptor signaling pathway
N0070555biological_processresponse to interleukin-1
N0070840molecular_functiondynein complex binding
N0071280biological_processcellular response to copper ion
N0071872biological_processcellular response to epinephrine stimulus
N0071902biological_processpositive regulation of protein serine/threonine kinase activity
N0097435biological_processsupramolecular fiber organization
N0098794cellular_componentpostsynapse
N0099512cellular_componentsupramolecular fiber
N1902957biological_processnegative regulation of mitochondrial electron transport, NADH to ubiquinone
N1903136molecular_functioncuprous ion binding
N1903284biological_processpositive regulation of glutathione peroxidase activity
N1903285biological_processpositive regulation of hydrogen peroxide catabolic process
N1903421biological_processregulation of synaptic vesicle recycling
N1903426biological_processregulation of reactive oxygen species biosynthetic process
N1904377biological_processpositive regulation of protein localization to cell periphery
N1904715biological_processnegative regulation of chaperone-mediated autophagy
N1905606biological_processregulation of presynapse assembly
N1990000biological_processamyloid fibril formation
N2000377biological_processregulation of reactive oxygen species metabolic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues24
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
LASP2
DHIS50
EASP2
EHIS50
IASP2
IHIS50
CASP2
CHIS50
NASP2
NHIS50
MASP2
LHIS50
MHIS50
BASP2
BHIS50
AASP2
AHIS50
KASP2
KHIS50
JASP2
JHIS50
FASP2
FHIS50
DASP2

site_idSWS_FT_FI2
Number of Residues12
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|PubMed:22407793
ChainResidueDetails
LMET1
MMET1
BMET1
AMET1
KMET1
JMET1
FMET1
DMET1
EMET1
IMET1
CMET1
NMET1

site_idSWS_FT_FI3
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617630
ChainResidueDetails
LSER87
MSER87
BSER87
ASER87
KSER87
JSER87
FSER87
DSER87
ESER87
ISER87
CSER87
NSER87

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: Phosphotyrosine; by FYN => ECO:0000269|PubMed:11162638, ECO:0000269|PubMed:12893833
ChainResidueDetails
LTYR125
MTYR125
BTYR125
ATYR125
KTYR125
JTYR125
FTYR125
DTYR125
ETYR125
ITYR125
CTYR125
NTYR125

site_idSWS_FT_FI5
Number of Residues12
DetailsMOD_RES: Phosphoserine; by BARK1, PLK2, CK2, CK1 and GRK5 => ECO:0000269|PubMed:10617630, ECO:0000269|PubMed:11813001, ECO:0000269|PubMed:24936070
ChainResidueDetails
LSER129
MSER129
BSER129
ASER129
KSER129
JSER129
FSER129
DSER129
ESER129
ISER129
CSER129
NSER129

222036

PDB entries from 2024-07-03

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