8CVZ

Human glycogenin-1 and glycogen synthase-1 complex in the apo ordered state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004373	molecular_function	glycogen (starch) synthase activity
A	0005978	biological_process	glycogen biosynthetic process
B	0004373	molecular_function	glycogen (starch) synthase activity
B	0005978	biological_process	glycogen biosynthetic process
C	0004373	molecular_function	glycogen (starch) synthase activity
C	0005978	biological_process	glycogen biosynthetic process
D	0004373	molecular_function	glycogen (starch) synthase activity
D	0005978	biological_process	glycogen biosynthetic process
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005978	biological_process	glycogen biosynthetic process
E	0008466	molecular_function	glycogenin glucosyltransferase activity
E	0016020	cellular_component	membrane
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0030145	molecular_function	manganese ion binding
E	0034774	cellular_component	secretory granule lumen
E	0042803	molecular_function	protein homodimerization activity
E	0043202	cellular_component	lysosomal lumen
E	0046872	molecular_function	metal ion binding
E	0102751	molecular_function	UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005978	biological_process	glycogen biosynthetic process
F	0008466	molecular_function	glycogenin glucosyltransferase activity
F	0016020	cellular_component	membrane
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0030145	molecular_function	manganese ion binding
F	0034774	cellular_component	secretory granule lumen
F	0042803	molecular_function	protein homodimerization activity
F	0043202	cellular_component	lysosomal lumen
F	0046872	molecular_function	metal ion binding
F	0102751	molecular_function	UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005978	biological_process	glycogen biosynthetic process
G	0008466	molecular_function	glycogenin glucosyltransferase activity
G	0016020	cellular_component	membrane
G	0016740	molecular_function	transferase activity
G	0016757	molecular_function	glycosyltransferase activity
G	0030145	molecular_function	manganese ion binding
G	0034774	cellular_component	secretory granule lumen
G	0042803	molecular_function	protein homodimerization activity
G	0043202	cellular_component	lysosomal lumen
G	0046872	molecular_function	metal ion binding
G	0102751	molecular_function	UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005978	biological_process	glycogen biosynthetic process
H	0008466	molecular_function	glycogenin glucosyltransferase activity
H	0016020	cellular_component	membrane
H	0016740	molecular_function	transferase activity
H	0016757	molecular_function	glycosyltransferase activity
H	0030145	molecular_function	manganese ion binding
H	0034774	cellular_component	secretory granule lumen
H	0042803	molecular_function	protein homodimerization activity
H	0043202	cellular_component	lysosomal lumen
H	0046872	molecular_function	metal ion binding
H	0102751	molecular_function	UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0005978	biological_process	glycogen biosynthetic process
I	0008466	molecular_function	glycogenin glucosyltransferase activity
I	0016020	cellular_component	membrane
I	0016740	molecular_function	transferase activity
I	0016757	molecular_function	glycosyltransferase activity
I	0030145	molecular_function	manganese ion binding
I	0034774	cellular_component	secretory granule lumen
I	0042803	molecular_function	protein homodimerization activity
I	0043202	cellular_component	lysosomal lumen
I	0046872	molecular_function	metal ion binding
I	0102751	molecular_function	UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0005978	biological_process	glycogen biosynthetic process
J	0008466	molecular_function	glycogenin glucosyltransferase activity
J	0016020	cellular_component	membrane
J	0016740	molecular_function	transferase activity
J	0016757	molecular_function	glycosyltransferase activity
J	0030145	molecular_function	manganese ion binding
J	0034774	cellular_component	secretory granule lumen
J	0042803	molecular_function	protein homodimerization activity
J	0043202	cellular_component	lysosomal lumen
J	0046872	molecular_function	metal ion binding
J	0102751	molecular_function	UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity
J	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:35835870, ECO:0007744|PDB:7Q13

Chain	Residue	Details
B	LYS39
D	HIS297
D	LYS301
D	THR515
A	LYS39
A	HIS297
A	LYS301
A	THR515
B	HIS297
B	LYS301
B	THR515
C	LYS39
C	HIS297
C	LYS301
C	THR515
D	LYS39

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000305|PubMed:35835870, ECO:0007744|PDB:7Q13

Chain	Residue	Details
B	HIS205
C	GLU510
C	TRP512
C	GLY513
D	HIS205
D	ARG211
D	ARG331
D	GLU510
D	TRP512
D	GLY513
A	HIS205
B	ARG211
A	ARG211
A	ARG331
A	GLU510
A	TRP512
A	GLY513
B	ARG331
B	GLU510
B	TRP512
B	GLY513
C	HIS205
C	ARG211
C	ARG331

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: in other chain => ECO:0000269|PubMed:35835870, ECO:0007744|PDB:7Q13

Chain	Residue	Details
B	HIS291
F	ASP102
F	ASP104
F	HIS212
G	ASP102
G	ASP104
G	HIS212
H	ASP102
H	ASP104
H	HIS212
B	GLU292
C	HIS291
C	GLU292
D	HIS291
D	GLU292
A	HIS291
A	GLU292
I	HIS212

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:35835870, ECO:0007744|PDB:7Q12, ECO:0007744|PDB:7Q13

Chain	Residue	Details
B	GLN294
D	HIS501
D	ARG582
D	ARG586
A	GLN294
A	HIS501
A	ARG582
A	ARG586
B	HIS501
B	ARG582
B	ARG586
C	GLN294
C	HIS501
C	ARG582
C	ARG586
D	GLN294

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphoserine; by AMPK and PKA => ECO:0000269|PubMed:35690592

Chain	Residue	Details
B	GLU8
C	GLU8
D	GLU8
A	GLU8
G	LYS86
H	LYS86

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P13834

Chain	Residue	Details
B	GLU11
C	GLU11
D	GLU11
A	GLU11
G	THR2
H	THR2

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:35690592, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER412
C	SER412
D	SER412
A	SER412
G	SER44
H	SER44

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	CARBOHYD: O-linked (Glc...) tyrosine => ECO:0000269|PubMed:22160680, ECO:0000269|PubMed:30356213, ECO:0007744|PDB:3U2U, ECO:0007744|PDB:3U2V

Chain	Residue	Details
J	PHE195
E	PHE195
I	PHE195
F	PHE195
G	PHE195
H	PHE195

---