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8CV3

Human Excitatory excitatory amino acid transporter 3 (EAAT3) protomer at in an intermediate outward facing sodium-bound state

Functional Information from GO Data
ChainGOidnamespacecontents
A0001662biological_processbehavioral fear response
A0001932biological_processregulation of protein phosphorylation
A0001975biological_processresponse to amphetamine
A0002027biological_processregulation of heart rate
A0005253molecular_functionmonoatomic anion channel activity
A0005313molecular_functionL-glutamate transmembrane transporter activity
A0005314molecular_functionhigh-affinity L-glutamate transmembrane transporter activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005886cellular_componentplasma membrane
A0006749biological_processglutathione metabolic process
A0006750biological_processglutathione biosynthetic process
A0006801biological_processsuperoxide metabolic process
A0006811biological_processmonoatomic ion transport
A0006836biological_processneurotransmitter transport
A0006865biological_processamino acid transport
A0006882biological_processintracellular zinc ion homeostasis
A0007212biological_processG protein-coupled dopamine receptor signaling pathway
A0007215biological_processglutamate receptor signaling pathway
A0007268biological_processchemical synaptic transmission
A0007420biological_processbrain development
A0007611biological_processlearning or memory
A0007613biological_processmemory
A0007625biological_processgrooming behavior
A0007626biological_processlocomotory behavior
A0009410biological_processresponse to xenobiotic stimulus
A0009986cellular_componentcell surface
A0010460biological_processpositive regulation of heart rate
A0010467biological_processgene expression
A0010842biological_processretina layer formation
A0015108molecular_functionchloride transmembrane transporter activity
A0015179molecular_functionL-amino acid transmembrane transporter activity
A0015183molecular_functionL-aspartate transmembrane transporter activity
A0015293molecular_functionsymporter activity
A0015501molecular_functionglutamate:sodium symporter activity
A0015813biological_processL-glutamate transmembrane transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0016595molecular_functionglutamate binding
A0019221biological_processcytokine-mediated signaling pathway
A0022008biological_processneurogenesis
A0030424cellular_componentaxon
A0030425cellular_componentdendrite
A0030534biological_processadult behavior
A0031901cellular_componentearly endosome membrane
A0031902cellular_componentlate endosome membrane
A0031982cellular_componentvesicle
A0032279cellular_componentasymmetric synapse
A0033229molecular_functioncysteine transmembrane transporter activity
A0034599biological_processcellular response to oxidative stress
A0035633biological_processmaintenance of blood-brain barrier
A0036293biological_processresponse to decreased oxygen levels
A0042417biological_processdopamine metabolic process
A0042802molecular_functionidentical protein binding
A0042883biological_processcysteine transport
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043083cellular_componentsynaptic cleft
A0043197cellular_componentdendritic spine
A0043198cellular_componentdendritic shaft
A0043204cellular_componentperikaryon
A0043278biological_processresponse to morphine
A0043524biological_processnegative regulation of neuron apoptotic process
A0043679cellular_componentaxon terminus
A0045121cellular_componentmembrane raft
A0045184biological_processestablishment of protein localization
A0045202cellular_componentsynapse
A0046872molecular_functionmetal ion binding
A0048514biological_processblood vessel morphogenesis
A0048678biological_processresponse to axon injury
A0050808biological_processsynapse organization
A0051402biological_processneuron apoptotic process
A0051938biological_processL-glutamate import
A0055037cellular_componentrecycling endosome
A0055038cellular_componentrecycling endosome membrane
A0060013biological_processrighting reflex
A0060041biological_processretina development in camera-type eye
A0060047biological_processheart contraction
A0060291biological_processlong-term synaptic potentiation
A0061744biological_processmotor behavior
A0070062cellular_componentextracellular exosome
A0070633biological_processtransepithelial transport
A0070777biological_processD-aspartate transmembrane transport
A0070778biological_processL-aspartate transmembrane transport
A0070779biological_processD-aspartate import across plasma membrane
A0071242biological_processcellular response to ammonium ion
A0071288biological_processcellular response to mercury ion
A0071314biological_processcellular response to cocaine
A0071407biological_processcellular response to organic cyclic compound
A0071577biological_processzinc ion transmembrane transport
A0071944cellular_componentcell periphery
A0072347biological_processresponse to anesthetic
A0090313biological_processregulation of protein targeting to membrane
A0090461biological_processintracellular glutamate homeostasis
A0097049biological_processmotor neuron apoptotic process
A0097386cellular_componentglial cell projection
A0097440cellular_componentapical dendrite
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098712biological_processL-glutamate import across plasma membrane
A0098793cellular_componentpresynapse
A0098877biological_processneurotransmitter receptor transport to plasma membrane
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0099544cellular_componentperisynaptic space
A0140009biological_processL-aspartate import across plasma membrane
A0140010molecular_functionD-aspartate transmembrane transporter activity
A0150002cellular_componentdistal dendrite
A0150104biological_processtransport across blood-brain barrier
A1902476biological_processchloride transmembrane transport
A1903712biological_processcysteine transmembrane transport
A1903926biological_processcellular response to bisphenol A
A1990635cellular_componentproximal dendrite
A1990708biological_processconditioned place preference
Functional Information from PROSITE/UniProt
site_idPS00713
Number of Residues15
DetailsNA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. P.GEiLMrMLKLIIlP
ChainResidueDetails
APRO55-PRO69

site_idPS00714
Number of Residues24
DetailsNA_DICARBOXYL_SYMP_2 Sodium:dicarboxylate symporter family signature 2. PvGaTiNMDGTaLYeaVaaVFIAQ
ChainResidueDetails
APRO360-GLN383

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues108
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AMET1-ASN18
AASP83-ARG93
AGLY230-ASP238
AVAL309-PRO313
AGLU345-ARG353
AGLU463-PHE524

site_idSWS_FT_FI2
Number of Residues59
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
ATRP19-VAL38
AMET62-LEU82
AALA94-VAL114

site_idSWS_FT_FI3
Number of Residues155
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
AARG39-ARG61
ASER115-MET205
AALA267-MET286
AILE381-GLN393
ALEU428-ASP440

site_idSWS_FT_FI4
Number of Residues23
DetailsTRANSMEM: Helical; Name=4 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
ATYR206-MET229

site_idSWS_FT_FI5
Number of Residues27
DetailsTRANSMEM: Helical; Name=5 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
APHE239-ILE266

site_idSWS_FT_FI6
Number of Residues21
DetailsTRANSMEM: Helical; Name=6 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
AALA287-VAL308

site_idSWS_FT_FI7
Number of Residues63
DetailsINTRAMEM: Discontinuously helical => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
APHE314-ALA344
AILE394-GLY427

site_idSWS_FT_FI8
Number of Residues26
DetailsTRANSMEM: Helical; Name=7 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
AILE354-PHE380

site_idSWS_FT_FI9
Number of Residues21
DetailsTRANSMEM: Helical; Name=8 => ECO:0000250|UniProtKB:P43003
ChainResidueDetails
ACYS441-VAL462

site_idSWS_FT_FI10
Number of Residues13
DetailsBINDING: BINDING => ECO:0000269|PubMed:33658209, ECO:0007744|PDB:6X2Z
ChainResidueDetails
ATYR98
AALA408
ATHR448
AASN451
AASP455
ATHR101
ATHR102
AGLY362
ATHR364
AASN366
AASP368
ASER405
AILE406

site_idSWS_FT_FI11
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:33658209, ECO:0007744|PDB:6X2Z, ECO:0007744|PDB:6X3E
ChainResidueDetails
ASER331
ASER333
ATHR370
AARG447

site_idSWS_FT_FI12
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:33658209, ECO:0007744|PDB:6X3E
ChainResidueDetails
AVAL411

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P51906
ChainResidueDetails
ASER517
ASER522

site_idSWS_FT_FI14
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN43
ATHR178
ATHR195

221716

PDB entries from 2024-06-26

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