8CMT
Structure of the plasma coagulation Factor XIII A2B2 heterotetrameric complex.
Functional Information from PROSITE/UniProt
| site_id | PS00547 |
| Number of Residues | 18 |
| Details | TRANSGLUTAMINASES Transglutaminases active site. GQCWVfAGVfnTfLRCLG |
| Chain | Residue | Details |
| A | GLY313-GLY330 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| C | ASN162 | |
| D | ASN162 | |
| A | ASP397 | |
| B | CYS315 | |
| B | HIS374 | |
| B | ASP397 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| C | ASN545 | |
| D | ASN545 | |
| A | GLU486 | |
| A | GLU491 | |
| B | ASN437 | |
| B | ASP439 | |
| B | GLU486 | |
| B | GLU491 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by thrombin; to produce active factor XIII-A |
| Chain | Residue | Details |
| A | ARG38 | |
| B | ARG38 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0000305|PubMed:2877456 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| A | ASN614 | |
| B | ASN614 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 149 |
| Chain | Residue | Details |
| A | TRP280 | electrostatic stabiliser, hydrogen bond donor |
| A | CYS315 | electrostatic stabiliser |
| A | HIS374 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | ASP397 | electrostatic stabiliser, hydrogen bond acceptor |
| A | TYR561 | electrostatic stabiliser, hydrogen bond donor |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 149 |
| Chain | Residue | Details |
| B | TRP280 | electrostatic stabiliser, hydrogen bond donor |
| B | CYS315 | electrostatic stabiliser |
| B | HIS374 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | ASP397 | electrostatic stabiliser, hydrogen bond acceptor |
| B | TYR561 | electrostatic stabiliser, hydrogen bond donor |
