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8CHJ

Human FKBP12 in complex with (1S,5S,6R)-10-((R)-(3,5-dichlorophenyl)sulfonimidoyl)-3-(pyridin-2-ylmethyl)-5-vinyl-3,10-diazabicyclo[4.3.1]decan-2-one

Functional Information from GO Data
ChainGOidnamespacecontents
A0000413biological_processprotein peptidyl-prolyl isomerization
A0003007biological_processheart morphogenesis
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0005160molecular_functiontransforming growth factor beta receptor binding
A0005515molecular_functionprotein binding
A0005527molecular_functionmacrolide binding
A0005528molecular_functionFK506 binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006357biological_processregulation of transcription by RNA polymerase II
A0006457biological_processprotein folding
A0006458biological_process'de novo' protein folding
A0014802cellular_componentterminal cisterna
A0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
A0016020cellular_componentmembrane
A0016247molecular_functionchannel regulator activity
A0016529cellular_componentsarcoplasmic reticulum
A0022417biological_processprotein maturation by protein folding
A0030018cellular_componentZ disc
A0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
A0030547molecular_functionsignaling receptor inhibitor activity
A0032092biological_processpositive regulation of protein binding
A0032880biological_processregulation of protein localization
A0032926biological_processnegative regulation of activin receptor signaling pathway
A0033017cellular_componentsarcoplasmic reticulum membrane
A0034713molecular_functiontype I transforming growth factor beta receptor binding
A0042026biological_processprotein refolding
A0042110biological_processT cell activation
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0044325molecular_functiontransmembrane transporter binding
A0050776biological_processregulation of immune response
A0055010biological_processventricular cardiac muscle tissue morphogenesis
A0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
A0060347biological_processheart trabecula formation
A0070411molecular_functionI-SMAD binding
A0070588biological_processcalcium ion transmembrane transport
A0070697molecular_functionactivin receptor binding
A0097435biological_processsupramolecular fiber organization
A0098562cellular_componentcytoplasmic side of membrane
A0140839molecular_functionRNA polymerase II CTD heptapeptide repeat P3 isomerase activity
A0140840molecular_functionRNA polymerase II CTD heptapeptide repeat P6 isomerase activity
A1902991biological_processregulation of amyloid precursor protein catabolic process
A1990000biological_processamyloid fibril formation
A1990425cellular_componentryanodine receptor complex
B0000413biological_processprotein peptidyl-prolyl isomerization
B0003007biological_processheart morphogenesis
B0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0005160molecular_functiontransforming growth factor beta receptor binding
B0005515molecular_functionprotein binding
B0005527molecular_functionmacrolide binding
B0005528molecular_functionFK506 binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006357biological_processregulation of transcription by RNA polymerase II
B0006457biological_processprotein folding
B0006458biological_process'de novo' protein folding
B0014802cellular_componentterminal cisterna
B0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
B0016020cellular_componentmembrane
B0016247molecular_functionchannel regulator activity
B0016529cellular_componentsarcoplasmic reticulum
B0022417biological_processprotein maturation by protein folding
B0030018cellular_componentZ disc
B0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
B0030547molecular_functionsignaling receptor inhibitor activity
B0032092biological_processpositive regulation of protein binding
B0032880biological_processregulation of protein localization
B0032926biological_processnegative regulation of activin receptor signaling pathway
B0033017cellular_componentsarcoplasmic reticulum membrane
B0034713molecular_functiontype I transforming growth factor beta receptor binding
B0042026biological_processprotein refolding
B0042110biological_processT cell activation
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0044325molecular_functiontransmembrane transporter binding
B0050776biological_processregulation of immune response
B0055010biological_processventricular cardiac muscle tissue morphogenesis
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0060347biological_processheart trabecula formation
B0070411molecular_functionI-SMAD binding
B0070588biological_processcalcium ion transmembrane transport
B0070697molecular_functionactivin receptor binding
B0097435biological_processsupramolecular fiber organization
B0098562cellular_componentcytoplasmic side of membrane
B0140839molecular_functionRNA polymerase II CTD heptapeptide repeat P3 isomerase activity
B0140840molecular_functionRNA polymerase II CTD heptapeptide repeat P6 isomerase activity
B1902991biological_processregulation of amyloid precursor protein catabolic process
B1990000biological_processamyloid fibril formation
B1990425cellular_componentryanodine receptor complex
C0000413biological_processprotein peptidyl-prolyl isomerization
C0003007biological_processheart morphogenesis
C0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
C0005160molecular_functiontransforming growth factor beta receptor binding
C0005515molecular_functionprotein binding
C0005527molecular_functionmacrolide binding
C0005528molecular_functionFK506 binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006357biological_processregulation of transcription by RNA polymerase II
C0006457biological_processprotein folding
C0006458biological_process'de novo' protein folding
C0014802cellular_componentterminal cisterna
C0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
C0016020cellular_componentmembrane
C0016247molecular_functionchannel regulator activity
C0016529cellular_componentsarcoplasmic reticulum
C0022417biological_processprotein maturation by protein folding
C0030018cellular_componentZ disc
C0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
C0030547molecular_functionsignaling receptor inhibitor activity
C0032092biological_processpositive regulation of protein binding
C0032880biological_processregulation of protein localization
C0032926biological_processnegative regulation of activin receptor signaling pathway
C0033017cellular_componentsarcoplasmic reticulum membrane
C0034713molecular_functiontype I transforming growth factor beta receptor binding
C0042026biological_processprotein refolding
C0042110biological_processT cell activation
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0044325molecular_functiontransmembrane transporter binding
C0050776biological_processregulation of immune response
C0055010biological_processventricular cardiac muscle tissue morphogenesis
C0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0060347biological_processheart trabecula formation
C0070411molecular_functionI-SMAD binding
C0070588biological_processcalcium ion transmembrane transport
C0070697molecular_functionactivin receptor binding
C0097435biological_processsupramolecular fiber organization
C0098562cellular_componentcytoplasmic side of membrane
C0140839molecular_functionRNA polymerase II CTD heptapeptide repeat P3 isomerase activity
C0140840molecular_functionRNA polymerase II CTD heptapeptide repeat P6 isomerase activity
C1902991biological_processregulation of amyloid precursor protein catabolic process
C1990000biological_processamyloid fibril formation
C1990425cellular_componentryanodine receptor complex
D0000413biological_processprotein peptidyl-prolyl isomerization
D0003007biological_processheart morphogenesis
D0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
D0005160molecular_functiontransforming growth factor beta receptor binding
D0005515molecular_functionprotein binding
D0005527molecular_functionmacrolide binding
D0005528molecular_functionFK506 binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006357biological_processregulation of transcription by RNA polymerase II
D0006457biological_processprotein folding
D0006458biological_process'de novo' protein folding
D0014802cellular_componentterminal cisterna
D0014809biological_processregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
D0016020cellular_componentmembrane
D0016247molecular_functionchannel regulator activity
D0016529cellular_componentsarcoplasmic reticulum
D0022417biological_processprotein maturation by protein folding
D0030018cellular_componentZ disc
D0030512biological_processnegative regulation of transforming growth factor beta receptor signaling pathway
D0030547molecular_functionsignaling receptor inhibitor activity
D0032092biological_processpositive regulation of protein binding
D0032880biological_processregulation of protein localization
D0032926biological_processnegative regulation of activin receptor signaling pathway
D0033017cellular_componentsarcoplasmic reticulum membrane
D0034713molecular_functiontype I transforming growth factor beta receptor binding
D0042026biological_processprotein refolding
D0042110biological_processT cell activation
D0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
D0044325molecular_functiontransmembrane transporter binding
D0050776biological_processregulation of immune response
D0055010biological_processventricular cardiac muscle tissue morphogenesis
D0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
D0060347biological_processheart trabecula formation
D0070411molecular_functionI-SMAD binding
D0070588biological_processcalcium ion transmembrane transport
D0070697molecular_functionactivin receptor binding
D0097435biological_processsupramolecular fiber organization
D0098562cellular_componentcytoplasmic side of membrane
D0140839molecular_functionRNA polymerase II CTD heptapeptide repeat P3 isomerase activity
D0140840molecular_functionRNA polymerase II CTD heptapeptide repeat P6 isomerase activity
D1902991biological_processregulation of amyloid precursor protein catabolic process
D1990000biological_processamyloid fibril formation
D1990425cellular_componentryanodine receptor complex
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P26883
ChainResidueDetails
ALYS52
BLYS52
CLYS52
DLYS52

Catalytic Information from CSA
site_idMCSA1
Number of Residues6
DetailsM-CSA 362
ChainResidueDetails
ATYR26electrostatic destabiliser, steric role
APHE36electrostatic destabiliser, polar/non-polar interaction, steric role
AASP37electrostatic stabiliser, steric role
AILE56electrostatic stabiliser, steric role
ATYR82electrostatic stabiliser, steric role
APHE99electrostatic destabiliser, polar/non-polar interaction, steric role

site_idMCSA2
Number of Residues6
DetailsM-CSA 362
ChainResidueDetails
BTYR26electrostatic destabiliser, steric role
BPHE36electrostatic destabiliser, polar/non-polar interaction, steric role
BASP37electrostatic stabiliser, steric role
BILE56electrostatic stabiliser, steric role
BTYR82electrostatic stabiliser, steric role
BPHE99electrostatic destabiliser, polar/non-polar interaction, steric role

site_idMCSA3
Number of Residues6
DetailsM-CSA 362
ChainResidueDetails
CTYR26electrostatic destabiliser, steric role
CPHE36electrostatic destabiliser, polar/non-polar interaction, steric role
CASP37electrostatic stabiliser, steric role
CILE56electrostatic stabiliser, steric role
CTYR82electrostatic stabiliser, steric role
CPHE99electrostatic destabiliser, polar/non-polar interaction, steric role

site_idMCSA4
Number of Residues6
DetailsM-CSA 362
ChainResidueDetails
DTYR26electrostatic destabiliser, steric role
DPHE36electrostatic destabiliser, polar/non-polar interaction, steric role
DASP37electrostatic stabiliser, steric role
DILE56electrostatic stabiliser, steric role
DTYR82electrostatic stabiliser, steric role
DPHE99electrostatic destabiliser, polar/non-polar interaction, steric role

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PDB entries from 2024-11-06

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