8CFX

Crystal structure of S-adenosyl-L-homocysteine hydrolase from P. aeruginosa in complex with F2X-Entry library fragment H06

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004013	molecular_function	adenosylhomocysteinase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006730	biological_process	one-carbon metabolic process
A	0016787	molecular_function	hydrolase activity
A	0033353	biological_process	S-adenosylmethionine cycle
A	0071269	biological_process	L-homocysteine biosynthetic process
B	0004013	molecular_function	adenosylhomocysteinase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006730	biological_process	one-carbon metabolic process
B	0016787	molecular_function	hydrolase activity
B	0033353	biological_process	S-adenosylmethionine cycle
B	0071269	biological_process	L-homocysteine biosynthetic process
C	0004013	molecular_function	adenosylhomocysteinase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006730	biological_process	one-carbon metabolic process
C	0016787	molecular_function	hydrolase activity
C	0033353	biological_process	S-adenosylmethionine cycle
C	0071269	biological_process	L-homocysteine biosynthetic process
D	0004013	molecular_function	adenosylhomocysteinase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006730	biological_process	one-carbon metabolic process
D	0016787	molecular_function	hydrolase activity
D	0033353	biological_process	S-adenosylmethionine cycle
D	0071269	biological_process	L-homocysteine biosynthetic process
G	0004013	molecular_function	adenosylhomocysteinase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006730	biological_process	one-carbon metabolic process
G	0016787	molecular_function	hydrolase activity
G	0033353	biological_process	S-adenosylmethionine cycle
G	0071269	biological_process	L-homocysteine biosynthetic process
H	0004013	molecular_function	adenosylhomocysteinase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006730	biological_process	one-carbon metabolic process
H	0016787	molecular_function	hydrolase activity
H	0033353	biological_process	S-adenosylmethionine cycle
H	0071269	biological_process	L-homocysteine biosynthetic process
I	0004013	molecular_function	adenosylhomocysteinase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006730	biological_process	one-carbon metabolic process
I	0016787	molecular_function	hydrolase activity
I	0033353	biological_process	S-adenosylmethionine cycle
I	0071269	biological_process	L-homocysteine biosynthetic process
J	0004013	molecular_function	adenosylhomocysteinase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006730	biological_process	one-carbon metabolic process
J	0016787	molecular_function	hydrolase activity
J	0033353	biological_process	S-adenosylmethionine cycle
J	0071269	biological_process	L-homocysteine biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00738
Number of Residues	15
Details	ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. SCNiFSTQDqAAAAI

Chain	Residue	Details
A	SER84-ILE98

---

site_id	PS00739
Number of Residues	17
Details	ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKqalViGYGdVGKGs.S

Chain	Residue	Details
A	GLY221-SER237

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00563","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---