8CFX

Crystal structure of S-adenosyl-L-homocysteine hydrolase from P. aeruginosa in complex with F2X-Entry library fragment H06

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004013	molecular_function	adenosylhomocysteinase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006730	biological_process	one-carbon metabolic process
A	0016787	molecular_function	hydrolase activity
A	0033353	biological_process	S-adenosylmethionine cycle
B	0004013	molecular_function	adenosylhomocysteinase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006730	biological_process	one-carbon metabolic process
B	0016787	molecular_function	hydrolase activity
B	0033353	biological_process	S-adenosylmethionine cycle
C	0004013	molecular_function	adenosylhomocysteinase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006730	biological_process	one-carbon metabolic process
C	0016787	molecular_function	hydrolase activity
C	0033353	biological_process	S-adenosylmethionine cycle
D	0004013	molecular_function	adenosylhomocysteinase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006730	biological_process	one-carbon metabolic process
D	0016787	molecular_function	hydrolase activity
D	0033353	biological_process	S-adenosylmethionine cycle
G	0004013	molecular_function	adenosylhomocysteinase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006730	biological_process	one-carbon metabolic process
G	0016787	molecular_function	hydrolase activity
G	0033353	biological_process	S-adenosylmethionine cycle
H	0004013	molecular_function	adenosylhomocysteinase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006730	biological_process	one-carbon metabolic process
H	0016787	molecular_function	hydrolase activity
H	0033353	biological_process	S-adenosylmethionine cycle
I	0004013	molecular_function	adenosylhomocysteinase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006730	biological_process	one-carbon metabolic process
I	0016787	molecular_function	hydrolase activity
I	0033353	biological_process	S-adenosylmethionine cycle
J	0004013	molecular_function	adenosylhomocysteinase activity
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006730	biological_process	one-carbon metabolic process
J	0016787	molecular_function	hydrolase activity
J	0033353	biological_process	S-adenosylmethionine cycle

Functional Information from PROSITE/UniProt

site_id	PS00738
Number of Residues	15
Details	ADOHCYASE_1 S-adenosyl-L-homocysteine hydrolase signature 1. SCNiFSTQDqAAAAI

Chain	Residue	Details
A	SER84-ILE98

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site_id	PS00739
Number of Residues	17
Details	ADOHCYASE_2 S-adenosyl-L-homocysteine hydrolase signature 2. GKqalViGYGdVGKGs.S

Chain	Residue	Details
A	GLY221-SER237

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	96
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00563

Chain	Residue	Details
A	THR63
A	ASP139
A	GLU164
A	THR165
A	LYS194
A	ASP198
A	ASN199
A	GLY228
A	GLU251
A	ASN300
A	ILE321
A	ASN375
B	THR63
B	ASP139
B	GLU164
B	THR165
B	LYS194
B	ASP198
B	ASN199
B	GLY228
B	GLU251
B	ASN300
B	ILE321
B	ASN375
C	THR63
C	ASP139
C	GLU164
C	THR165
C	LYS194
C	ASP198
C	ASN199
C	GLY228
C	GLU251
C	ASN300
C	ILE321
C	ASN375
D	THR63
D	ASP139
D	GLU164
D	THR165
D	LYS194
D	ASP198
D	ASN199
D	GLY228
D	GLU251
D	ASN300
D	ILE321
D	ASN375
G	THR63
G	ASP139
G	GLU164
G	THR165
G	LYS194
G	ASP198
G	ASN199
G	GLY228
G	GLU251
G	ASN300
G	ILE321
G	ASN375
H	THR63
H	ASP139
H	GLU164
H	THR165
H	LYS194
H	ASP198
H	ASN199
H	GLY228
H	GLU251
H	ASN300
H	ILE321
H	ASN375
I	THR63
I	ASP139
I	GLU164
I	THR165
I	LYS194
I	ASP198
I	ASN199
I	GLY228
I	GLU251
I	ASN300
I	ILE321
I	ASN375
J	THR63
J	ASP139
J	GLU164
J	THR165
J	LYS194
J	ASP198
J	ASN199
J	GLY228
J	GLU251
J	ASN300
J	ILE321
J	ASN375

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