8CDZ
human carbonic anhydrase I complexed with 4-(3-butylureido)benzenesulfonamide
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| AAA | 0004064 | molecular_function | arylesterase activity |
| AAA | 0004089 | molecular_function | carbonate dehydratase activity |
| AAA | 0005515 | molecular_function | protein binding |
| AAA | 0005737 | cellular_component | cytoplasm |
| AAA | 0005829 | cellular_component | cytosol |
| AAA | 0006730 | biological_process | one-carbon metabolic process |
| AAA | 0016829 | molecular_function | lyase activity |
| AAA | 0016836 | molecular_function | hydro-lyase activity |
| AAA | 0018820 | molecular_function | cyanamide hydratase activity |
| AAA | 0046872 | molecular_function | metal ion binding |
| AAA | 0070062 | cellular_component | extracellular exosome |
| BBB | 0004064 | molecular_function | arylesterase activity |
| BBB | 0004089 | molecular_function | carbonate dehydratase activity |
| BBB | 0005515 | molecular_function | protein binding |
| BBB | 0005737 | cellular_component | cytoplasm |
| BBB | 0005829 | cellular_component | cytosol |
| BBB | 0006730 | biological_process | one-carbon metabolic process |
| BBB | 0016829 | molecular_function | lyase activity |
| BBB | 0016836 | molecular_function | hydro-lyase activity |
| BBB | 0018820 | molecular_function | cyanamide hydratase activity |
| BBB | 0046872 | molecular_function | metal ion binding |
| BBB | 0070062 | cellular_component | extracellular exosome |
Functional Information from PROSITE/UniProt
| site_id | PS00162 |
| Number of Residues | 17 |
| Details | ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdgvkYsaELHVA |
| Chain | Residue | Details |
| AAA | SER105-ALA121 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:P00918 |
| Chain | Residue | Details |
| AAA | HIS64 | |
| BBB | HIS64 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: in variant Michigan-1 => ECO:0000269|PubMed:12009884 |
| Chain | Residue | Details |
| AAA | HIS64 | |
| AAA | HIS67 | |
| AAA | HIS200 | |
| BBB | HIS64 | |
| BBB | HIS67 | |
| BBB | HIS200 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12009884, ECO:0000269|PubMed:15299369, ECO:0000269|PubMed:16506782, ECO:0000269|PubMed:16870440, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17407288, ECO:0000269|PubMed:6430186, ECO:0000269|PubMed:7932756, ECO:0000269|PubMed:804171, ECO:0000269|PubMed:8057362 |
| Chain | Residue | Details |
| AAA | HIS94 | |
| AAA | HIS96 | |
| AAA | HIS119 | |
| BBB | HIS94 | |
| BBB | HIS96 | |
| BBB | HIS119 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:8057362 |
| Chain | Residue | Details |
| AAA | THR199 | |
| BBB | THR199 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:4207120, ECO:0000269|PubMed:4217196 |
| Chain | Residue | Details |
| AAA | ALA1 | |
| BBB | ALA1 |
