8CDK

CAND1 b-hairpin++-SCF-SKP2 CAND1 partly engaged SCF partly rocked

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000082	biological_process	G1/S transition of mitotic cell cycle
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0006513	biological_process	protein monoubiquitination
C	0006915	biological_process	apoptotic process
C	0008283	biological_process	cell population proliferation
C	0009887	biological_process	animal organ morphogenesis
C	0010498	biological_process	proteasomal protein catabolic process
C	0016567	biological_process	protein ubiquitination
C	0019005	cellular_component	SCF ubiquitin ligase complex
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
C	0031461	cellular_component	cullin-RING ubiquitin ligase complex
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0070936	biological_process	protein K48-linked ubiquitination
C	0097193	biological_process	intrinsic apoptotic signaling pathway
C	0160072	molecular_function	ubiquitin ligase complex scaffold activity
C	1990452	cellular_component	Parkin-FBXW7-Cul1 ubiquitin ligase complex
D	0000151	cellular_component	ubiquitin ligase complex
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0010265	biological_process	SCF complex assembly
D	0016020	cellular_component	membrane
D	0016567	biological_process	protein ubiquitination
D	0017025	molecular_function	TBP-class protein binding
D	0030154	biological_process	cell differentiation
D	0031461	cellular_component	cullin-RING ubiquitin ligase complex
D	0034774	cellular_component	secretory granule lumen
D	0043086	biological_process	negative regulation of catalytic activity
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
D	0070062	cellular_component	extracellular exosome
D	1904813	cellular_component	ficolin-1-rich granule lumen
F	0000082	biological_process	G1/S transition of mitotic cell cycle
F	0000086	biological_process	G2/M transition of mitotic cell cycle
F	0000209	biological_process	protein polyubiquitination
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005730	cellular_component	nucleolus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0016567	biological_process	protein ubiquitination
F	0019005	cellular_component	SCF ubiquitin ligase complex
F	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
F	0033148	biological_process	positive regulation of intracellular estrogen receptor signaling pathway
F	0042802	molecular_function	identical protein binding
F	0042981	biological_process	regulation of apoptotic process
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0045087	biological_process	innate immune response
F	0051607	biological_process	defense response to virus
F	0051726	biological_process	regulation of cell cycle
F	0070534	biological_process	protein K63-linked ubiquitination
F	0070936	biological_process	protein K48-linked ubiquitination
F	1902916	biological_process	positive regulation of protein polyubiquitination
F	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
F	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity
R	0000165	biological_process	MAPK cascade
R	0000209	biological_process	protein polyubiquitination
R	0004842	molecular_function	ubiquitin-protein transferase activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005654	cellular_component	nucleoplasm
R	0005737	cellular_component	cytoplasm
R	0005829	cellular_component	cytosol
R	0006281	biological_process	DNA repair
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0006513	biological_process	protein monoubiquitination
R	0006974	biological_process	DNA damage response
R	0007283	biological_process	spermatogenesis
R	0008270	molecular_function	zinc ion binding
R	0016567	biological_process	protein ubiquitination
R	0016740	molecular_function	transferase activity
R	0019005	cellular_component	SCF ubiquitin ligase complex
R	0019788	molecular_function	NEDD8 transferase activity
R	0030163	biological_process	protein catabolic process
R	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
R	0031461	cellular_component	cullin-RING ubiquitin ligase complex
R	0031462	cellular_component	Cul2-RING ubiquitin ligase complex
R	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
R	0031464	cellular_component	Cul4A-RING E3 ubiquitin ligase complex
R	0031465	cellular_component	Cul4B-RING E3 ubiquitin ligase complex
R	0031466	cellular_component	Cul5-RING ubiquitin ligase complex
R	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
R	0031625	molecular_function	ubiquitin protein ligase binding
R	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
R	0032480	biological_process	negative regulation of type I interferon production
R	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
R	0034599	biological_process	cellular response to oxidative stress
R	0034644	biological_process	cellular response to UV
R	0042110	biological_process	T cell activation
R	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
R	0043687	biological_process	post-translational protein modification
R	0045116	biological_process	protein neddylation
R	0045732	biological_process	positive regulation of protein catabolic process
R	0046872	molecular_function	metal ion binding
R	0060090	molecular_function	molecular adaptor activity
R	0061629	molecular_function	RNA polymerase II-specific DNA-binding transcription factor binding
R	0061630	molecular_function	ubiquitin protein ligase activity
R	0061663	molecular_function	NEDD8 ligase activity
R	0062197	biological_process	cellular response to chemical stress
R	0070936	biological_process	protein K48-linked ubiquitination
R	0071230	biological_process	cellular response to amino acid stimulus
R	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
R	0097602	molecular_function	cullin family protein binding
R	0140627	biological_process	ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
R	1900076	biological_process	regulation of cellular response to insulin stimulus
R	1902499	biological_process	positive regulation of protein autoubiquitination
R	1902883	biological_process	negative regulation of response to oxidative stress
R	1904263	biological_process	positive regulation of TORC1 signaling
S	0000209	biological_process	protein polyubiquitination
S	0005515	molecular_function	protein binding
S	0005634	cellular_component	nucleus
S	0005654	cellular_component	nucleoplasm
S	0005737	cellular_component	cytoplasm
S	0005813	cellular_component	centrosome
S	0005829	cellular_component	cytosol
S	0006338	biological_process	chromatin remodeling
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0006513	biological_process	protein monoubiquitination
S	0008013	molecular_function	beta-catenin binding
S	0016567	biological_process	protein ubiquitination
S	0019005	cellular_component	SCF ubiquitin ligase complex
S	0019904	molecular_function	protein domain specific binding
S	0031146	biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
S	0031467	cellular_component	Cul7-RING ubiquitin ligase complex
S	0031519	cellular_component	PcG protein complex
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0051457	biological_process	maintenance of protein location in nucleus
S	0070936	biological_process	protein K48-linked ubiquitination
S	0097602	molecular_function	cullin family protein binding
S	0140677	molecular_function	molecular function activator activity
S	0160072	molecular_function	ubiquitin ligase complex scaffold activity
S	1904668	biological_process	positive regulation of ubiquitin protein ligase activity
S	1990444	molecular_function	F-box domain binding
S	1990756	molecular_function	ubiquitin-like ligase-substrate adaptor activity

Functional Information from PROSITE/UniProt

site_id	PS01256
Number of Residues	28
Details	CULLIN_1 Cullin family signature. IKkcIdiLIEKeYLeRvdgekdtYsYlA

Chain	Residue	Details
C	ILE749-ALA776

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	SER64

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; by p300/EP300 => ECO:0000269|PubMed:22770219

Chain	Residue	Details
F	LYS68
F	LYS71
R	CYS75
R	HIS77
R	HIS80
R	CYS94
R	ASP97

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	SER72
F	SER75
R	CYS68
R	HIS82

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:23186163

Chain	Residue	Details
F	SER179

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
R	THR9

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