Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8C97

Cryo-EM captures early ribosome assembly in action

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000027	biological_process	ribosomal large subunit assembly
0	0000302	biological_process	response to reactive oxygen species
0	0002181	biological_process	cytoplasmic translation
0	0003735	molecular_function	structural constituent of ribosome
0	0005515	molecular_function	protein binding
0	0005737	cellular_component	cytoplasm
0	0005829	cellular_component	cytosol
0	0005840	cellular_component	ribosome
0	0006412	biological_process	translation
0	0009314	biological_process	response to radiation
0	0015934	cellular_component	large ribosomal subunit
0	0022625	cellular_component	cytosolic large ribosomal subunit
0	1990904	cellular_component	ribonucleoprotein complex
2	0002181	biological_process	cytoplasmic translation
2	0003735	molecular_function	structural constituent of ribosome
2	0005515	molecular_function	protein binding
2	0005737	cellular_component	cytoplasm
2	0005840	cellular_component	ribosome
2	0006412	biological_process	translation
2	0022625	cellular_component	cytosolic large ribosomal subunit
2	1990904	cellular_component	ribonucleoprotein complex
D	0000027	biological_process	ribosomal large subunit assembly
D	0002181	biological_process	cytoplasmic translation
D	0003735	molecular_function	structural constituent of ribosome
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0019843	molecular_function	rRNA binding
D	0022625	cellular_component	cytosolic large ribosomal subunit
D	1990904	cellular_component	ribonucleoprotein complex
E	0001070	molecular_function	RNA-binding transcription regulator activity
E	0002181	biological_process	cytoplasmic translation
E	0003677	molecular_function	DNA binding
E	0003735	molecular_function	structural constituent of ribosome
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005840	cellular_component	ribosome
E	0006353	biological_process	DNA-templated transcription termination
E	0006412	biological_process	translation
E	0006417	biological_process	regulation of translation
E	0015934	cellular_component	large ribosomal subunit
E	0017148	biological_process	negative regulation of translation
E	0019843	molecular_function	rRNA binding
E	0022625	cellular_component	cytosolic large ribosomal subunit
E	0030371	molecular_function	translation repressor activity
E	0031555	biological_process	transcriptional attenuation
E	0042255	biological_process	ribosome assembly
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0046677	biological_process	response to antibiotic
E	0048027	molecular_function	mRNA 5'-UTR binding
E	0060698	molecular_function	endoribonuclease inhibitor activity
E	1990904	cellular_component	ribonucleoprotein complex
E	2000766	biological_process	negative regulation of cytoplasmic translation
K	0002181	biological_process	cytoplasmic translation
K	0003735	molecular_function	structural constituent of ribosome
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0005829	cellular_component	cytosol
K	0005840	cellular_component	ribosome
K	0006412	biological_process	translation
K	0015934	cellular_component	large ribosomal subunit
K	0019843	molecular_function	rRNA binding
K	0022625	cellular_component	cytosolic large ribosomal subunit
K	0070180	molecular_function	large ribosomal subunit rRNA binding
K	1990904	cellular_component	ribonucleoprotein complex
N	0000027	biological_process	ribosomal large subunit assembly
N	0002181	biological_process	cytoplasmic translation
N	0003735	molecular_function	structural constituent of ribosome
N	0005515	molecular_function	protein binding
N	0005737	cellular_component	cytoplasm
N	0005829	cellular_component	cytosol
N	0005840	cellular_component	ribosome
N	0006412	biological_process	translation
N	0022625	cellular_component	cytosolic large ribosomal subunit
N	1990904	cellular_component	ribonucleoprotein complex
P	0000027	biological_process	ribosomal large subunit assembly
P	0002181	biological_process	cytoplasmic translation
P	0003735	molecular_function	structural constituent of ribosome
P	0005737	cellular_component	cytoplasm
P	0005829	cellular_component	cytosol
P	0005840	cellular_component	ribosome
P	0006412	biological_process	translation
P	0019843	molecular_function	rRNA binding
P	0022625	cellular_component	cytosolic large ribosomal subunit
P	0070180	molecular_function	large ribosomal subunit rRNA binding
P	1990904	cellular_component	ribonucleoprotein complex
S	0002181	biological_process	cytoplasmic translation
S	0003735	molecular_function	structural constituent of ribosome
S	0005515	molecular_function	protein binding
S	0005737	cellular_component	cytoplasm
S	0005829	cellular_component	cytosol
S	0005840	cellular_component	ribosome
S	0006412	biological_process	translation
S	0015934	cellular_component	large ribosomal subunit
S	0019843	molecular_function	rRNA binding
S	0022625	cellular_component	cytosolic large ribosomal subunit
S	0042255	biological_process	ribosome assembly
S	0042256	biological_process	cytosolic ribosome assembly
S	0046677	biological_process	response to antibiotic
S	0070180	molecular_function	large ribosomal subunit rRNA binding
S	1902626	biological_process	assembly of large subunit precursor of preribosome
S	1990904	cellular_component	ribonucleoprotein complex
T	0000027	biological_process	ribosomal large subunit assembly
T	0002181	biological_process	cytoplasmic translation
T	0003735	molecular_function	structural constituent of ribosome
T	0005515	molecular_function	protein binding
T	0005737	cellular_component	cytoplasm
T	0005840	cellular_component	ribosome
T	0006412	biological_process	translation
T	0019843	molecular_function	rRNA binding
T	0022625	cellular_component	cytosolic large ribosomal subunit
T	1990904	cellular_component	ribonucleoprotein complex
U	0000027	biological_process	ribosomal large subunit assembly
U	0002181	biological_process	cytoplasmic translation
U	0003723	molecular_function	RNA binding
U	0003735	molecular_function	structural constituent of ribosome
U	0005515	molecular_function	protein binding
U	0005737	cellular_component	cytoplasm
U	0005829	cellular_component	cytosol
U	0005840	cellular_component	ribosome
U	0006412	biological_process	translation
U	0019843	molecular_function	rRNA binding
U	0022625	cellular_component	cytosolic large ribosomal subunit
U	0070180	molecular_function	large ribosomal subunit rRNA binding
U	1990904	cellular_component	ribonucleoprotein complex
Y	0000027	biological_process	ribosomal large subunit assembly
Y	0002181	biological_process	cytoplasmic translation
Y	0003735	molecular_function	structural constituent of ribosome
Y	0005737	cellular_component	cytoplasm
Y	0005840	cellular_component	ribosome
Y	0006412	biological_process	translation
Y	0019843	molecular_function	rRNA binding
Y	0022625	cellular_component	cytosolic large ribosomal subunit
Y	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00049
Number of Residues	27
Details	RIBOSOMAL_L14 Ribosomal protein L14 signature. AVVVrtkkgvrrp.DGsvirFdgNacVL

Chain	Residue	Details
K	ALA60-LEU86

site_id	PS00050
Number of Residues	16
Details	RIBOSOMAL_L23 Ribosomal protein L23 signature. KKAYVTLKegqnldfV

Chain	Residue	Details
T	LYS81-VAL96

site_id	PS00430
Number of Residues	66
Details	TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. mireerllkvlraphvsekastameksntivlkvakdatkaeikaavqklfevevevv.........................................................NTLVVKGK

Chain	Residue	Details
T	MET1-LYS66

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. KriMpRAkGRadrilkrtSHITVvV

Chain	Residue	Details
S	LYS83-VAL107

site_id	PS00474
Number of Residues	24
Details	RIBOSOMAL_L3 Ribosomal protein L3 signature. FadvkkvDvtGtSkGKGfaGtvkR

Chain	Residue	Details
D	PHE101-ARG124

site_id	PS00579
Number of Residues	15
Details	RIBOSOMAL_L29 Ribosomal protein L29 signature. QSHLLKqVRRDVARV

Chain	Residue	Details
Y	GLN39-VAL53

site_id	PS00784
Number of Residues	20
Details	RIBOSOMAL_L34 Ribosomal protein L34 signature. KRTFQpsvlkRnrsh.GFraR

Chain	Residue	Details
2	LYS2-ARG21

site_id	PS01015
Number of Residues	16
Details	RIBOSOMAL_L19 Ribosomal protein L19 signature. VkRrGAVR.KAKLYYLR

Chain	Residue	Details
P	VAL85-ARG100

site_id	PS01108
Number of Residues	18
Details	RIBOSOMAL_L24 Ribosomal protein L24 signature. DDeViVLtGkdKGkr.GkV

Chain	Residue	Details
U	ASP7-VAL24

site_id	PS01167
Number of Residues	23
Details	RIBOSOMAL_L17 Ribosomal protein L17 signature. IkTTlpKaKelrrvvEpLITlAK

Chain	Residue	Details
N	ILE34-LYS56

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000269\|PubMed:21151122

Chain	Residue	Details
D	LYS38

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N5-methylglutamine => ECO:0000269\|PubMed:365579, ECO:0000305\|PubMed:331083

Chain	Residue	Details
D	GLN150

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)