Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

8C8Q

Cytochrome c oxidase from Schizosaccharomyces pombe

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004129	molecular_function	cytochrome-c oxidase activity
A	0009060	biological_process	aerobic respiration
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0045277	cellular_component	respiratory chain complex IV
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005507	molecular_function	copper ion binding
B	0005743	cellular_component	mitochondrial inner membrane
B	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0022900	biological_process	electron transport chain
B	0022904	biological_process	respiratory electron transport chain
B	0031966	cellular_component	mitochondrial membrane
B	0042773	biological_process	ATP synthesis coupled electron transport
B	0045277	cellular_component	respiratory chain complex IV
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0004129	molecular_function	cytochrome-c oxidase activity
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0019646	biological_process	aerobic electron transport chain
C	0022904	biological_process	respiratory electron transport chain
C	0031966	cellular_component	mitochondrial membrane
C	0045277	cellular_component	respiratory chain complex IV
C	0045333	biological_process	cellular respiration
C	1902600	biological_process	proton transmembrane transport
D	0004129	molecular_function	cytochrome-c oxidase activity
D	0005739	cellular_component	mitochondrion
D	0005740	cellular_component	mitochondrial envelope
D	0005743	cellular_component	mitochondrial inner membrane
D	0006119	biological_process	oxidative phosphorylation
D	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
D	0031966	cellular_component	mitochondrial membrane
D	0045277	cellular_component	respiratory chain complex IV
D	0045333	biological_process	cellular respiration
D	0046872	molecular_function	metal ion binding
D	1902600	biological_process	proton transmembrane transport
E	0004129	molecular_function	cytochrome-c oxidase activity
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006119	biological_process	oxidative phosphorylation
E	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
E	0016491	molecular_function	oxidoreductase activity
E	0031966	cellular_component	mitochondrial membrane
E	0045277	cellular_component	respiratory chain complex IV
E	0045333	biological_process	cellular respiration
E	1902600	biological_process	proton transmembrane transport
F	0004129	molecular_function	cytochrome-c oxidase activity
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006119	biological_process	oxidative phosphorylation
F	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
F	0031966	cellular_component	mitochondrial membrane
F	0045277	cellular_component	respiratory chain complex IV
F	0045333	biological_process	cellular respiration
F	0046872	molecular_function	metal ion binding
F	1902600	biological_process	proton transmembrane transport
G	0004129	molecular_function	cytochrome-c oxidase activity
G	0005743	cellular_component	mitochondrial inner membrane
G	0006119	biological_process	oxidative phosphorylation
G	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
G	0016491	molecular_function	oxidoreductase activity
G	0031966	cellular_component	mitochondrial membrane
G	0045277	cellular_component	respiratory chain complex IV
G	0045333	biological_process	cellular respiration
G	1902600	biological_process	proton transmembrane transport
H	0004129	molecular_function	cytochrome-c oxidase activity
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006119	biological_process	oxidative phosphorylation
H	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
H	0016491	molecular_function	oxidoreductase activity
H	0031966	cellular_component	mitochondrial membrane
H	0045277	cellular_component	respiratory chain complex IV
H	0045333	biological_process	cellular respiration
H	1902600	biological_process	proton transmembrane transport
I	0004129	molecular_function	cytochrome-c oxidase activity
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006119	biological_process	oxidative phosphorylation
I	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
I	0016491	molecular_function	oxidoreductase activity
I	0031966	cellular_component	mitochondrial membrane
I	0045277	cellular_component	respiratory chain complex IV
I	0045333	biological_process	cellular respiration
I	1902600	biological_process	proton transmembrane transport
J	0004129	molecular_function	cytochrome-c oxidase activity
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006119	biological_process	oxidative phosphorylation
J	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
J	0031966	cellular_component	mitochondrial membrane
J	0045277	cellular_component	respiratory chain complex IV
J	0045333	biological_process	cellular respiration
J	1902600	biological_process	proton transmembrane transport
K	0004129	molecular_function	cytochrome-c oxidase activity
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0006119	biological_process	oxidative phosphorylation
K	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
K	0016491	molecular_function	oxidoreductase activity
K	0030234	molecular_function	enzyme regulator activity
K	0031966	cellular_component	mitochondrial membrane
K	0045277	cellular_component	respiratory chain complex IV
K	0045333	biological_process	cellular respiration
K	1902600	biological_process	proton transmembrane transport
L	0003674	molecular_function	molecular_function
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
L	0016020	cellular_component	membrane
L	0031966	cellular_component	mitochondrial membrane
L	0033617	biological_process	mitochondrial respiratory chain complex IV assembly
L	0045333	biological_process	cellular respiration
L	0098803	cellular_component	respiratory chain complex

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyilimpafgvvshiipslahkpifgkegmlwamlsiallglmvws..HH

Chain	Residue	Details
A	TRP243-HIS297

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHswavpslgikcdcipgrlnqvslsidreglfygq......CselCgvlHssM

Chain	Residue	Details
B	VAL180-MET228

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. LIWmtvykdklrrCpeCGsvYKL

Chain	Residue	Details
D	LEU130-LEU152

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. LRfKkYpWGDGsKTlFwN

Chain	Residue	Details
K	LEU102-ASN119

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	523
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00401","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"UniProtKB","id":"P00401","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00396","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Cross-link: {"description":"1'-histidyl-3'-tyrosine (His-Tyr)","evidences":[{"source":"UniProtKB","id":"P00401","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	17
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P00410","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00692","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04037","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	6
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"UniProtKB","id":"P04039","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	20
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"UniProtKB","id":"P07255","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	43
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	10
Details	Motif: {"description":"Cx9C motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	11
Details	Motif: {"description":"Cx10C motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	40
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00836","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)