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8C80

Cryo-EM structure of the yeast SPT-Orm1-Monomer complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003674molecular_functionmolecular_function
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006672biological_processceramide metabolic process
A0006986biological_processresponse to unfolded protein
A0016020cellular_componentmembrane
A0017059cellular_componentserine palmitoyltransferase complex
A0030148biological_processsphingolipid biosynthetic process
A0090155biological_processnegative regulation of sphingolipid biosynthetic process
A0090156biological_processintracellular sphingolipid homeostasis
B0004758molecular_functionserine C-palmitoyltransferase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0006665biological_processsphingolipid metabolic process
B0009058biological_processbiosynthetic process
B0016020cellular_componentmembrane
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0017059cellular_componentserine palmitoyltransferase complex
B0030148biological_processsphingolipid biosynthetic process
B0030170molecular_functionpyridoxal phosphate binding
B0046512biological_processsphingosine biosynthetic process
B0046513biological_processceramide biosynthetic process
B0090156biological_processintracellular sphingolipid homeostasis
C0004758molecular_functionserine C-palmitoyltransferase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0006665biological_processsphingolipid metabolic process
C0009058biological_processbiosynthetic process
C0016020cellular_componentmembrane
C0016740molecular_functiontransferase activity
C0016746molecular_functionacyltransferase activity
C0017059cellular_componentserine palmitoyltransferase complex
C0030148biological_processsphingolipid biosynthetic process
C0030170molecular_functionpyridoxal phosphate binding
C0046512biological_processsphingosine biosynthetic process
C0046513biological_processceramide biosynthetic process
C0090156biological_processintracellular sphingolipid homeostasis
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0006666biological_process3-keto-sphinganine metabolic process
D0008047molecular_functionenzyme activator activity
D0016020cellular_componentmembrane
D0017059cellular_componentserine palmitoyltransferase complex
D0090154biological_processpositive regulation of sphingolipid biosynthetic process
D0090156biological_processintracellular sphingolipid homeostasis
Functional Information from PROSITE/UniProt
site_idPS00599
Number of Residues10
DetailsAA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site. TFTKSFGAAG
ChainResidueDetails
CTHR363-GLY372

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
DPHE54-ILE74
CLEU443-PRO463
AHIS206-SER222

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250
ChainResidueDetails
CLYS366
BASP342-MET371
BALA425-LYS457
ALEU185-THR205

site_idSWS_FT_FI3
Number of Residues356
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15485854
ChainResidueDetails
BLYS85-MET341
BPHE458-LYS558

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17330950
ChainResidueDetails
BTHR121

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198
ChainResidueDetails
ASER32

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198
ChainResidueDetails
ASER56

223532

PDB entries from 2024-08-07

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